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    Atac3 Ada2a-containing complex component 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38055, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atac3provided by FlyBase
    Official Full Name
    Ada2a-containing complex component 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0052343
    Locus tag
    Dmel_CG32343
    See related
    AllianceGenome:FB:FBgn0052343
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32343; cg6994; CG6994; dAtac3; dATAC3; Dmel\CG32343
    Summary
    Predicted to enable transcription cis-regulatory region binding activity. Involved in chromatin remodeling. Part of ATAC complex. Is expressed in organism. Orthologous to several human genes including GABPB2 (GA binding protein transcription factor subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Atac3 in Genome Data Viewer
    Location:
    61C1-61C1; 3-0.5 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (324985..327992, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (324985..327992, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene four wheel drive Neighboring gene deadbeat Neighboring gene uncharacterized protein Neighboring gene Protein tyrosine phosphatase Meg Neighboring gene methuselah-like 9 Neighboring gene methuselah-like 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding. Suganuma T, et al. Nat Struct Mol Biol, 2008 Apr. PMID 18327268
    2. Lint-O cooperates with L(3)mbt in target gene suppression to maintain homeostasis in fly ovary and brain. Yamamoto-Matsuda H, et al. EMBO Rep, 2022 Oct 6. PMID 35993198, Free PMC Article
    3. A metazoan ATAC acetyltransferase subunit that regulates mitogen-activated protein kinase signaling is related to an ancient molybdopterin synthase component. Suganuma T, et al. Mol Cell Proteomics, 2012 May. PMID 22345504, Free PMC Article
    4. The ATAC acetyltransferase complex coordinates MAP kinases to regulate JNK target genes. Suganuma T, et al. Cell, 2010 Sep 3. PMID 20813260
    5. In vivo functional characterization of the SARS-Coronavirus 3a protein in Drosophila. Wong SL, et al. Biochem Biophys Res Commun, 2005 Nov 18. PMID 16212942, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ATAC complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ada2a-containing complex component 3
    Names
    ATAC complex component 3
    Atac3-PB
    Atac3-PC
    Atac3-PD
    Atac3-PE
    CG32343-PB
    CG32343-PC
    CG32343-PD
    CG32343-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      324985..327992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259602.2 → NP_001246531.1  Ada2a-containing complex component 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246531.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFF9
      Conserved Domains (4) summary
      cd00204
      Location:81 → 204
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:90 → 181
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:58 → 106
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:88 → 116
      ANK; ANK repeat [structural motif]

    2. NM_167828.4 → NP_728520.2  Ada2a-containing complex component 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728520.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0R7
      Conserved Domains (4) summary
      cd00204
      Location:81 → 204
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:90 → 181
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:58 → 106
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:88 → 116
      ANK; ANK repeat [structural motif]

    3. NM_001144394.2 → NP_001137866.1  Ada2a-containing complex component 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137866.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0R7
      Conserved Domains (4) summary
      cd00204
      Location:81 → 204
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:90 → 181
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:58 → 106
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:88 → 116
      ANK; ANK repeat [structural motif]

    4. NM_001274275.1 → NP_001261204.1  Ada2a-containing complex component 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261204.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFF9
      Conserved Domains (4) summary
      cd00204
      Location:81 → 204
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:90 → 181
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:58 → 106
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:88 → 116
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NFF9 M9NFF9
    Q9W0R7 Q9W0R7

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