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    Dmtn Dementin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40792, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dmtnprovided by FlyBase
    Official Full Name
    Dementinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037443
    Locus tag
    Dmel_CG1021
    See related
    AllianceGenome:FB:FBgn0037443
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.375; CG1021; Dmel\CG1021; dmtn
    Summary
    Involved in brain development. Located in endomembrane system and plasma membrane. Is expressed in adult head; embryonic/larval optic lobe; glial cell; photoreceptor neurons; and synaptic neuropil domain. Used to study alcohol-related neurodevelopmental disorder. Orthologous to several human genes including TMCC1 (transmembrane and coiled-coil domain family 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dmtn in Genome Data Viewer
    Location:
    83E5-83E6; 3-47.5 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6389162..6405895, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2214884..2231617, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Transcription factor IIFalpha Neighboring gene godzilla E3 ubiquitin protein ligase Neighboring gene long non-coding RNA:CR44017 Neighboring gene grappa Neighboring gene mir-9375 stem loop Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental ethanol exposure causes central nervous system dysfunction and may slow the aging process in a Drosophila model of fetal alcohol spectrum disorder. Belhorma K, et al. Alcohol, 2021 Aug. PMID 33961967
    2. Neurodegeneration in a Drosophila model for the function of TMCC2, an amyloid protein precursor-interacting and apolipoprotein E-binding protein. Hopkins PC. PLoS One, 2013. PMID 23409049, Free PMC Article
    3. Drosophila as a model to study the role of glia in neurodegeneration. Lee YM, et al. J Neurogenet, 2015. PMID 26312528
    4. Scrutinizing the human TEX genes in the context of human male infertility. Sieper MH, et al. Andrology, 2024 Mar. PMID 37594251
    5. Variation in the response to exercise stimulation in Drosophila: marathon runner versus sprinter genotypes. Riddle NC. J Exp Biol, 2020 Sep 21. PMID 32737212

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c6397874-6397779 mobile_element_type = transposon:INE-1{}5812

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    dementin
    Names
    CG1021-PD
    CG1021-PE
    CG1021-PF
    CG1021-PG
    CG1021-PH
    Dmtn-PD
    Dmtn-PE
    Dmtn-PF
    Dmtn-PG
    Dmtn-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6389162..6405895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141397.5 → NP_649654.3  dementin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649654.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN36, Q9VI21
      Conserved Domains (1) summary
      pfam10267
      Location:212 → 617
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    2. NM_001144544.3 → NP_001138016.1  dementin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138016.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0W3
      Conserved Domains (1) summary
      pfam10267
      Location:74 → 479
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    3. NM_001170060.2 → NP_001163531.1  dementin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163531.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJ71
      Conserved Domains (1) summary
      pfam10267
      Location:253 → 658
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    4. NM_001144543.3 → NP_001138015.1  dementin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138015.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN36, Q9VI21
      Conserved Domains (1) summary
      pfam10267
      Location:212 → 617
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    5. NM_169141.4 → NP_731081.2  dementin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731081.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN36, Q9VI21
      Conserved Domains (1) summary
      pfam10267
      Location:212 → 617
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z0W3 B7Z0W3
    E1JJ71 E1JJ71
    Q960J3 Q960J3
    Q9VI21 Q9VI21

    Gene LinkOut

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