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    zen2 zerknullt-related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40827, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zen2provided by FlyBase
    Official Full Name
    zerknullt-relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004054
    Locus tag
    Dmel_CG1048
    See related
    AllianceGenome:FB:FBgn0004054
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS00276.10; CG1048; Dmel\CG1048; z2; zpr
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including amnioserosa; amnioserosa anlage; dorsal ectoderm; dorsal ectoderm anlage; and dorsal fold. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See zen2 in Genome Data Viewer
    Location:
    84A5-84A5; 3-48 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6743135..6744136, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2568857..2569858, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ccp84Aa Neighboring gene proboscipedia Neighboring gene uncharacterized protein Neighboring gene zerknullt

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The proboscipedia locus of the Antennapedia complex: a molecular and genetic analysis. Pultz MA, et al. Genes Dev, 1988 Jul. PMID 2850265
    2. Molecular characterization of the zerknüllt region of the Antennapedia gene complex in Drosophila. Rushlow C, et al. Genes Dev, 1987 Dec. PMID 2892759
    3. Maternal regulation of zerknüllt: a homoeobox gene controlling differentiation of dorsal tissues in Drosophila. Rushlow C, et al. Nature, 1987 Dec 10-16. PMID 2891036
    4. Class 3 Hox genes in insects and the origin of zen. Falciani F, et al. Proc Natl Acad Sci U S A, 1996 Aug 6. PMID 8710895, Free PMC Article
    5. Ectopic expression of the Drosophila homeotic gene proboscipedia under Antennapedia P1 control causes dominant thoracic defects. Cribbs DL, et al. Genetics, 1992 Nov. PMID 1361474, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zerknullt-related
    Names
    CG1048-PA
    CG1048-PB
    Zerknullt-related
    zen-pattern-related
    zen2-PA
    zen2-PB
    zerknullt 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6743135..6744136 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057446.3 → NP_476794.1  zerknullt-related, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476794.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P09090, Q9V3K6
      Related
      FBpp0081171
      Conserved Domains (1) summary
      pfam00046
      Location:46 → 99
      Homeobox; Homeobox domain

    2. NM_001144545.2 → NP_001138017.1  zerknullt-related, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138017.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0IGT0
      Conserved Domains (1) summary
      pfam00046
      Location:26 → 79
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09090.2 P09090
    Q0IGT0 Q0IGT0

    Gene LinkOut

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