Ppp1r10 protein phosphatase 1, regulatory subunit 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp1r10provided by MGI
Official Full Name: protein phosphatase 1, regulatory subunit 10provided by MGI
Primary source: MGI:MGI:1289273
See related: Ensembl:ENSMUSG00000039220 AllianceGenome:MGI:1289273
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fb19; Cat53; Pnuts; D17Ertd808e; 2610025H06Rik
Summary: Predicted to enable protein phosphatase 1 binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of cardiac muscle cell apoptotic process; negative regulation of mitotic DNA damage checkpoint; and positive regulation of telomere maintenance. Located in chromatin. Part of PTW/PP1 phosphatase complex. Is expressed in central nervous system; early conceptus; oocyte; and retina. Orthologous to human PPP1R10 (protein phosphatase 1 regulatory subunit 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 26.6), thymus adult (RPKM 16.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.77 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (36227404..36243175)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (35916512..35932283)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression.
Title: Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression.
stimulation of PP1 activity via siRNA mediated knockdown of its interacting protein PNUTS (Phosphatase Nuclear Targeting Subunit) leads to Rb dephosphorylation and apoptosis in cancer cells
Title: PNUTS knockdown potentiates the apoptotic effect of Roscovitine in breast and colon cancer cells.
Protein phosphatase 1 (PP1) and GABA(C) receptors simultaneously bind to different domains of PNUTS, demonstrating that PNUTS crosslinks PP1 and GABA(C) receptors.
Title: PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Transgenic (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17Ertd808e (e-PCR), detects polymorphism
- UniSTS:167227

NoName (e-PCR)
- UniSTS:237642

NoName (e-PCR)
- UniSTS:235150

C76158 (e-PCR)
- UniSTS:209305

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 1 binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 1 binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase 1 binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein phosphatase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of cardiac muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic DNA damage checkpoint	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitotic DNA damage checkpoint	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of PTW/PP1 phosphatase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PTW/PP1 phosphatase complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
colocalizes_with chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 1 regulatory subunit 10

Names: HLA-C adjacent transcript 53; MHC class I region proline-rich protein CAT53; protein phosphatase I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163818.1 → NP_001157290.1 serine/threonine-protein phosphatase 1 regulatory subunit 10

See identical proteins and their annotated locations for NP_001157290.1

Status: VALIDATED

Source sequence(s)

AW456628, BC052059

Consensus CDS

CCDS50098.1

UniProtKB/Swiss-Prot

B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8

UniProtKB/TrEMBL

Q3ULI5

Related

ENSMUSP00000084460.7, ENSMUST00000087210.7

Conserved Domains (2) summary

pfam18044
Location:858 → 880

zf-CCCH_4; CCCH-type zinc finger

cl00146
Location:102 → 146

TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
NM_001357740.1 → NP_001344669.1 serine/threonine-protein phosphatase 1 regulatory subunit 10

Status: VALIDATED

Source sequence(s)

AJ504718, CR974451

Consensus CDS

CCDS50098.1

UniProtKB/Swiss-Prot

B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8

UniProtKB/TrEMBL

Q3ULI5

Conserved Domains (2) summary

pfam18044
Location:858 → 880

zf-CCCH_4; CCCH-type zinc finger

cl00146
Location:102 → 146

TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
NM_001403564.1 → NP_001390493.1 serine/threonine-protein phosphatase 1 regulatory subunit 10

Status: VALIDATED

Source sequence(s)

CR974451

UniProtKB/Swiss-Prot

B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8

UniProtKB/TrEMBL

Q3ULI5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

36227404..36243175

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160685.1 → XP_036016578.1 serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

UniProtKB/Swiss-Prot

B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8

UniProtKB/TrEMBL

Q3ULI5

Conserved Domains (2) summary

pfam18044
Location:858 → 880

zf-CCCH_4; CCCH-type zinc finger

cl00146
Location:102 → 146

TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
XM_006524617.2 → XP_006524680.1 serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

See identical proteins and their annotated locations for XP_006524680.1

UniProtKB/Swiss-Prot

B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8

UniProtKB/TrEMBL

Q3ULI5

Related

ENSMUSP00000084461.3, ENSMUST00000087211.9

Conserved Domains (2) summary

pfam18044
Location:858 → 880

zf-CCCH_4; CCCH-type zinc finger

cl00146
Location:102 → 146

TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
XM_006524619.3 → XP_006524682.1 serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

See identical proteins and their annotated locations for XP_006524682.1

UniProtKB/Swiss-Prot

B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8

UniProtKB/TrEMBL

Q3ULI5

Conserved Domains (2) summary

pfam18044
Location:858 → 880

zf-CCCH_4; CCCH-type zinc finger

cl00146
Location:102 → 146

TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
XM_030249898.2 → XP_030105758.1 serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

UniProtKB/Swiss-Prot

B1B179, Q80W00, Q811B6, Q8C6T7, Q8K2U8

UniProtKB/TrEMBL

Q3ULI5

Conserved Domains (2) summary

pfam18044
Location:858 → 880

zf-CCCH_4; CCCH-type zinc finger

cl00146
Location:102 → 146

TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_175934.3: Suppressed sequence

Description

NM_175934.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein