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    Anxa8 annexin A8 [ Mus musculus (house mouse) ]

    Gene ID: 11752, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Anxa8provided by MGI
    Official Full Name
    annexin A8provided by MGI
    Primary source
    MGI:MGI:1201374
    See related
    Ensembl:ENSMUSG00000021950 AllianceGenome:MGI:1201374
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Anx8
    Summary
    Predicted to enable several functions, including actin filament binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipid binding activity. Predicted to be involved in endosomal transport and endosome organization. Predicted to be located in cytosol; late endosome membrane; and plasma membrane. Predicted to be active in cytoplasm; sarcolemma; and vesicle membrane. Is expressed in several structures, including genitourinary system; gut; respiratory system; sensory organ; and skin. Orthologous to human ANXA8 (annexin A8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 12.6), placenta adult (RPKM 6.3) and 10 other tissues See more
    Orthologs
    all
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    Genomic context

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    See Anxa8 in Genome Data Viewer
    Location:
    14 B; 14 20.8 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (33807936..33822528)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34085979..34100571)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30083 Neighboring gene STARR-seq mESC enhancer starr_36360 Neighboring gene predicted gene 5460 Neighboring gene RIKEN cDNA A630023A22 gene Neighboring gene anthrax toxin receptor-like Neighboring gene STARR-seq mESC enhancer starr_36361 Neighboring gene predicted gene, 24998 Neighboring gene predicted gene, 30556

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium. Iglesias JM, et al. PLoS One, 2015. PMID 25803307, Free PMC Article
    2. Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes. Heitzig N, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Apr. PMID 29306076
    3. Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63. Poeter M, et al. Nat Commun, 2014 Apr 28. PMID 24769558
    4. Bone matrix regulates osteoclast differentiation and annexin A8 gene expression. Crotti TN, et al. J Cell Physiol, 2011 Dec. PMID 21344395
    5. Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer. Stein T, et al. Clin Cancer Res, 2005 Oct 1. PMID 16203777

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.
      Title: Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.
    2. Define a distinct bone-dependent genetic program associated with terminal osteoclast differentiation and identified Anxa8 as a gene strongly induced late in osteoclast differentiation, regulating formation of the cell's characteristic actin ring.
      Title: Bone matrix regulates osteoclast differentiation and annexin A8 gene expression.
    3. Annexin A8 is involved in mouse mammary gland involution and progression of human breast cancer
      Title: Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer.
    4. ANXA8 protein is most abundant in stratified epithelia of the postnatal mouse. Its location in the suprabasal layers suggests that ANXA8 may be associated with the terminal differentiation of epithelial cells in these tissues.
      Title: Specific expression of annexin A8 in adult murine stratified epithelia.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC40628

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    annexin A8
    Names
    annexin 8
    annexin VIII

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281845.1 → NP_001268774.1  annexin A8 isoform 2

      See identical proteins and their annotated locations for NP_001268774.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC164099, AJ002390, AK009085, AK075870
      Consensus CDS
      CCDS70565.1
      UniProtKB/TrEMBL
      Q921D0
      Related
      ENSMUSP00000113662.2, ENSMUST00000120077.2
      Conserved Domains (1) summary
      pfam00191
      Location:26 → 90
      Annexin; Annexin

    2. NM_013473.4 → NP_038501.2  annexin A8 isoform 1

      See identical proteins and their annotated locations for NP_038501.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC164099, AJ002390, AK009085, AK075870
      Consensus CDS
      CCDS26932.1
      UniProtKB/Swiss-Prot
      O35640, Q8K2N9
      Related
      ENSMUSP00000022519.9, ENSMUST00000022519.15
      Conserved Domains (1) summary
      pfam00191
      Location:26 → 90
      Annexin; Annexin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      33807936..33822528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35640.2 GenPept UniProtKB/Swiss-Prot:O35640

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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