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    CD82 CD82 molecule [ Homo sapiens (human) ]

    Gene ID: 3732, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CD82provided by HGNC
    Official Full Name
    CD82 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:6210
    See related
    Ensembl:ENSG00000085117 MIM:600623; AllianceGenome:HGNC:6210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    R2; 4F9; C33; IA4; ST6; GR15; KAI1; SAR2; TSPAN27
    Summary
    This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in esophagus (RPKM 44.7), bone marrow (RPKM 32.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CD82 in Genome Data Viewer
    Location:
    11p11.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (44564409..44620358)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (44720425..44776379)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (44587213..44641908)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44550187-44551103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44556450-44556973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44556974-44557496 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3273 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:44561345-44561951 Neighboring gene ribosomal protein L7a pseudogene 79 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3274 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:44580713-44581349 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44583385-44583886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44583887-44584386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44587226-44587726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4654 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4655 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4657 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44617773-44618351 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44618352-44618931 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44619920-44620420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44620421-44620921 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44622959-44623562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44630450-44630950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4659 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3277 Neighboring gene CD82 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4660 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44656670-44657458 Neighboring gene ribosomal protein L34 pseudogene 22 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44675065-44675680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44676298-44676913 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:44685723-44686240 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:44692285-44693064 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:44693065-44693844 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:44693845-44694623 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:44710524-44711057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44713680-44714180 Neighboring gene long intergenic non-protein coding RNA 2704

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of the metastasis suppressor KAI1 in decidual cells at the human maternal-fetal interface: Regulation and functional implications. Gellersen B, et al. Am J Pathol, 2007 Jan. PMID 17200188, Free PMC Article
    2. Alternative splicing of KAI1 abrogates its tumor-suppressive effects on integrin αvβ3-mediated ovarian cancer biology. Upheber S, et al. Cell Signal, 2015 Mar. PMID 25435431
    3. KAI1/CD82 is a novel target of estrogen receptor-mediated gene repression and downregulated in primary human breast cancer. Christgen M, et al. Int J Cancer, 2008 Nov 15. PMID 18712725
    4. Down-regulation of the metastasis suppressor protein KAI1/CD82 correlates with occurrence of metastasis, prognosis and presence of HPV DNA in human penile squamous cell carcinoma. Protzel C, et al. Virchows Arch, 2008 Apr. PMID 18305955
    5. KAI1 gene suppresses invasion and metastasis of hepatocellular carcinoma MHCC97-H cells in vitro and in animal models. Yang JM, et al. Liver Int, 2008 Jan. PMID 18028322

    See all (234) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNA Hypermethylation Inhibits the CD82 Metastasis Suppressor Gene in Gastric Cancer.
      Title: DNA Hypermethylation Inhibits the CD82 Metastasis Suppressor Gene in Gastric Cancer.
    2. CD81 and CD82 expressing tumor-infiltrating lymphocytes in the NSCLC tumor microenvironment play a crucial role in T-cell activation and cytokine production.
      Title: CD81 and CD82 expressing tumor-infiltrating lymphocytes in the NSCLC tumor microenvironment play a crucial role in T-cell activation and cytokine production.
    3. Tetraspanin CD82 Correlates with and May Regulate S100A7 Expression in Oral Cancer.
      Title: Tetraspanin CD82 Correlates with and May Regulate S100A7 Expression in Oral Cancer.
    4. Tetraspanin CD82 Associates with Trafficking Vesicle in Muscle Cells and Binds to Dysferlin and Myoferlin.
      Title: Tetraspanin CD82 Associates with Trafficking Vesicle in Muscle Cells and Binds to Dysferlin and Myoferlin.
    5. Expression of KAI1 and AGR2 in lung adenocarcinoma and their clinicopathological significance.
      Title: Expression of KAI1 and AGR2 in lung adenocarcinoma and their clinicopathological significance.
    6. Lower expression of KAI1 as a biomarker of poor survival prognosis of melanoma combined with colorectal cancer metastasis.
      Title: Lower expression of KAI1 as a biomarker of poor survival prognosis of melanoma combined with colorectal cancer metastasis.
    7. Proteomic profiling of plasma exosomes reveals CD82 involvement in the development of esophageal squamous cell carcinoma.
      Title: Proteomic profiling of plasma exosomes reveals CD82 involvement in the development of esophageal squamous cell carcinoma.
    8. A positive COX-2/IL-1beta loop promotes decidualization by upregulating CD82.
      Title: A positive COX-2/IL-1β loop promotes decidualization by upregulating CD82.
    9. The Role of CK7, S100A1, and CD82 (KAI1) Expression in the Differential Diagnosis of Chromophobe Renal Cell Carcinoma and Renal Oncocytoma.
      Title: The Role of CK7, S100A1, and CD82 (KAI1) Expression in the Differential Diagnosis of Chromophobe Renal Cell Carcinoma and Renal Oncocytoma.
    10. CD82 is a marker to isolate beta cell precursors from human iPS cells and plays a role for the maturation of beta cells.
      Title: CD82 is a marker to isolate β cell precursors from human iPS cells and plays a role for the maturation of β cells.
    Submit: New GeneRIF Correction See all GeneRIFs (174)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.
    EBI GWAS Catalog
    Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD82 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tetraspanin proteins, such as CD9, CD63, CD81, CD82, and CD231, are incorporated on the membrane of released virions in an HIV-1 envelope protein (Env)-independent manner and have the potential to inhibit HIV-1 Env-mediated infection PubMed
    Envelope surface glycoprotein gp160, precursor env Tetraspanin proteins, such as CD9, CD63, CD81, CD82, and CD231, are incorporated on the membrane of released virions in an HIV-1 envelope protein (Env)-independent manner and have the potential to inhibit HIV-1 Env-mediated infection PubMed
    env CD82 localizes to endosome compartments and is incorporated into the viral envelope of macrophage-derived HIV-1 particles PubMed
    env DLG1 knockdown is associated with the redistribution and colocalization of Env toward CD63 and CD82 positive vesicle-like structures PubMed
    Pr55(Gag) gag HIV-1 Gag proteins co-localize with tetraspanins CD9, CD81, and CD82 in CD63-enriched micro domains PubMed
    gag DLG1 knockdown is associated with the redistribution and colocalization of Gag toward CD63 and CD82 positive vesicle-like structures PubMed
    Vpu vpu HIV-1 Vpu is the main determinant for the overall downregulation of CD82 in HIV-1-infected CD4+ T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CD82 antigen
    Names
    C33 antigen
    inducible membrane protein R2
    kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))
    metastasis suppressor Kangai-1
    tetraspanin-27
    tspan-27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023234.1 RefSeqGene

      Range
      5073..59768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001024844.2 → NP_001020015.1  CD82 antigen isoform 2

      See identical proteins and their annotated locations for NP_001020015.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, as compared to variant 1. The encoded isoform (2) thus lacks a segment in the middle region, as compared to isoform 1.
      Source sequence(s)
      AC010768, AY303776, CB127804, U20770
      Consensus CDS
      CCDS31469.1
      UniProtKB/TrEMBL
      Q6LET0
      Related
      ENSP00000339686.3, ENST00000342935.7
      Conserved Domains (2) summary
      cd03160
      Location:86 → 204
      CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:24 → 231
      Tetraspannin; Tetraspanin family

    2. NM_002231.4 → NP_002222.1  CD82 antigen isoform 1

      See identical proteins and their annotated locations for NP_002222.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC010768, CB127804, U20770
      Consensus CDS
      CCDS7909.1
      UniProtKB/Swiss-Prot
      D3DQN6, E9PC70, P27701, Q7Z2D4, Q7Z5N2
      UniProtKB/TrEMBL
      Q6LET0
      Related
      ENSP00000227155.4, ENST00000227155.9
      Conserved Domains (2) summary
      cd03160
      Location:106 → 229
      CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:24 → 256
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      44564409..44620358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426900.1 → XP_047282856.1  CD82 antigen isoform X1

    2. XM_047426901.1 → XP_047282857.1  CD82 antigen isoform X2

    3. XM_047426903.1 → XP_047282859.1  CD82 antigen isoform X3

      UniProtKB/Swiss-Prot
      D3DQN6, E9PC70, P27701, Q7Z2D4, Q7Z5N2

    4. XM_047426904.1 → XP_047282860.1  CD82 antigen isoform X3

      UniProtKB/Swiss-Prot
      D3DQN6, E9PC70, P27701, Q7Z2D4, Q7Z5N2

    5. XM_011520067.3 → XP_011518369.1  CD82 antigen isoform X4

      UniProtKB/TrEMBL
      Q6LET0
      Related
      ENST00000530931.2
      Conserved Domains (2) summary
      cd03160
      Location:75 → 198
      CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:23 → 225
      Tetraspannin; Tetraspanin family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      44720425..44776379
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368698.1 → XP_054224673.1  CD82 antigen isoform X1

    2. XM_054368699.1 → XP_054224674.1  CD82 antigen isoform X2

    3. XM_054368700.1 → XP_054224675.1  CD82 antigen isoform X3

      UniProtKB/Swiss-Prot
      D3DQN6, E9PC70, P27701, Q7Z2D4, Q7Z5N2

    4. XM_054368701.1 → XP_054224676.1  CD82 antigen isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27701.1 GenPept UniProtKB/Swiss-Prot:P27701

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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