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    NAV2 neuron navigator 2 [ Homo sapiens (human) ]

    Gene ID: 89797, updated on 27-Nov-2024

    Summary

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    Official Symbol
    NAV2provided by HGNC
    Official Full Name
    neuron navigator 2provided by HGNC
    Primary source
    HGNC:HGNC:15997
    See related
    Ensembl:ENSG00000166833 MIM:607026; AllianceGenome:HGNC:15997
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HELAD1; RAINB1; POMFIL2; UNC53H2; STEERIN2
    Summary
    This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Broad expression in thyroid (RPKM 4.0), brain (RPKM 3.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NAV2 in Genome Data Viewer
    Location:
    11p15.1
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (19345236..20121601)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (19465285..20242238)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (19366783..20143147)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:19253866-19255065 Neighboring gene CSRP3 and E2F8 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3198 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4515 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:19263697-19264268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:19264269-19264838 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:19290948-19291137 Neighboring gene Sharpr-MPRA regulatory region 11719 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4516 Neighboring gene E2F transcription factor 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4517 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4518 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3199 Neighboring gene proliferating cell nuclear antigen pseudogene 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:19416525-19417056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4519 Neighboring gene MPRA-validated peak1231 silencer Neighboring gene RNA, 5S ribosomal pseudogene 335 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:19463438-19464637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4521 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4522 Neighboring gene NAV2 antisense RNA 5 Neighboring gene NAV2 antisense RNA 4 Neighboring gene small nucleolar RNA SNORA1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19823 Neighboring gene microRNA 4486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4523 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:19691725-19692246 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19830 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:19719279-19719442 Neighboring gene NANOG hESC enhancer GRCh37_chr11:19722632-19723146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:19725055-19725555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:19724554-19725054 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:19734258-19734451 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:19768963-19769464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:19778561-19779113 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:19793703-19794210 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:19794211-19794719 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3201 Neighboring gene lncRNA enhancing IL-6/STAT3 signaling activation 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:19842672-19843172 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:19843173-19843673 Neighboring gene microRNA 4694 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:19913575-19914774 Neighboring gene Sharpr-MPRA regulatory region 6685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4524 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:20000027-20001226 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:20021347-20022216 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:20022217-20023085 Neighboring gene uncharacterized LOC124902644 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:20046732-20047316 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:20048270-20048921 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:20048922-20049572 Neighboring gene NAV2 antisense RNA 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:20070019-20071218 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:20086241-20087043 Neighboring gene NAV2 antisense RNA 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:20133119-20134018 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:20134019-20134918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:20135723-20136224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:20136225-20136724 Neighboring gene uncharacterized LOC107984418 Neighboring gene uncharacterized LOC124902643 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:20177816-20179015 Neighboring gene developing brain homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease. Wang KS, et al. J Neuroimmunol, 2017 Sep 15. PMID 28778446, Free PMC Article
    2. NAV2 positively modulates inflammatory response of fibroblast-like synoviocytes through activating Wnt/β-catenin signaling pathway in rheumatoid arthritis. Wang R, et al. Clin Transl Med, 2021 Apr. PMID 33931978, Free PMC Article
    3. Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas. Ishiguro H, et al. Oncogene, 2002 Sep 12. PMID 12214280
    4. Identification of novel genes including NAV2 associated with isolated tall stature. Weiss B, et al. Front Endocrinol (Lausanne), 2023. PMID 38152138, Free PMC Article
    5. Neuron navigator-2 and cyclin D2 are new candidate prognostic markers in uterine sarcoma. Davidson B, et al. Virchows Arch, 2017 Sep. PMID 28643014

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of novel genes including NAV2 associated with isolated tall stature.
      Title: Identification of novel genes including NAV2 associated with isolated tall stature.
    2. NAV2 positively modulates inflammatory response of fibroblast-like synoviocytes through activating Wnt/beta-catenin signaling pathway in rheumatoid arthritis.
      Title: NAV2 positively modulates inflammatory response of fibroblast-like synoviocytes through activating Wnt/β-catenin signaling pathway in rheumatoid arthritis.
    3. DNA hypermethylation is associated with invasive phenotype of malignant melanoma.
      Title: DNA hypermethylation is associated with invasive phenotype of malignant melanoma.
    4. Study found that melanoma tissues showed an upregulated expression of NAV2 which correlated with poor prognosis of cutaneous melanoma. NAV2-mediated invasion of melanoma cells was driven by enhanced epithelial-mesenchymal transition, which was resulted from SNAI2 upregulation via the GSK-3beta/beta-catenin pathway.
      Title: NAV2 facilitates invasion of cutaneous melanoma cells by targeting SNAI2 through the GSK-3β/β-catenin pathway.
    5. NAV2 and CCND2 are novel candidate prognostic markers in uterine leiomyosarcoma and uterine low-grade endometrial stromal sarcoma, respectively.
      Title: Neuron navigator-2 and cyclin D2 are new candidate prognostic markers in uterine sarcoma.
    6. The present study is the first study providing evidence of several genetic variants within the NAV2 gene influencing the risk and age at onset of Alzheimer's disease.
      Title: Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease.
    7. interaction between NAV2 and 14-3-3epsilon
      Title: 14-3-3ε and NAV2 interact to regulate neurite outgrowth and axon elongation.
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    9. a novel gene, termed HELAD1 (helicase, APC down-regulated 1) plays important role in colorectal carcinogenesis (HELAD1)
      Title: Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas.
    10. regulated by all-trans retinoic acid in neuroblastoma cells
      Title: A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder.
    EBI GWAS Catalog
    Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10633, FLJ11030, FLJ23707, FLJ77876, KIAA1419

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glossopharyngeal nerve development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in optic nerve development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of systemic arterial blood pressure by baroreceptor feedback IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vagus nerve development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in interstitial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    neuron navigator 2
    Names
    helicase, APC down-regulated 1
    pore membrane and/or filament-interacting-like protein 2
    retinoic acid inducible gene in neuroblastoma 1
    steerin-2
    unc-53 homolog 2
    NP_001104488.1
    NP_001104489.1
    NP_001231892.1
    NP_660093.2
    NP_892009.3
    XP_005253271.1
    XP_006718427.1
    XP_006718428.1
    XP_006718429.1
    XP_011518746.1
    XP_011518747.1
    XP_011518748.1
    XP_011518749.1
    XP_011518750.1
    XP_011518751.1
    XP_011518752.1
    XP_016874009.1
    XP_016874010.1
    XP_016874011.1
    XP_016874013.1
    XP_024304526.1
    XP_047283765.1
    XP_047283766.1
    XP_047283767.1
    XP_047283768.1
    XP_047283769.1
    XP_047283770.1
    XP_047283771.1
    XP_047283772.1
    XP_047283773.1
    XP_047283774.1
    XP_047283775.1
    XP_047283776.1
    XP_047283777.1
    XP_047283778.1
    XP_047283779.1
    XP_047283780.1
    XP_047283781.1
    XP_047283782.1
    XP_047283783.1
    XP_047283784.1
    XP_047283785.1
    XP_047283786.1
    XP_047283787.1
    XP_047283789.1
    XP_047283790.1
    XP_047283791.1
    XP_047283792.1
    XP_047283793.1
    XP_047283794.1
    XP_054226346.1
    XP_054226347.1
    XP_054226348.1
    XP_054226349.1
    XP_054226350.1
    XP_054226351.1
    XP_054226352.1
    XP_054226353.1
    XP_054226354.1
    XP_054226355.1
    XP_054226356.1
    XP_054226357.1
    XP_054226358.1
    XP_054226359.1
    XP_054226360.1
    XP_054226361.1
    XP_054226362.1
    XP_054226363.1
    XP_054226364.1
    XP_054226365.1
    XP_054226366.1
    XP_054226367.1
    XP_054226368.1
    XP_054226369.1
    XP_054226370.1
    XP_054226371.1
    XP_054226372.1
    XP_054226373.1
    XP_054226374.1
    XP_054226375.1
    XP_054226376.1
    XP_054226377.1
    XP_054226378.1
    XP_054226379.1
    XP_054226380.1
    XP_054226381.1
    XP_054226382.1
    XP_054226383.1
    XP_054226384.1
    XP_054226385.1
    XP_054226386.1
    XP_054226387.1
    XP_054226388.1
    XP_054226389.1
    XP_054226390.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030347.2 RefSeqGene

      Range
      372603..781367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001111018.2 → NP_001104488.1  neuron navigator 2 isoform 3

      See identical proteins and their annotated locations for NP_001104488.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' exon and represents use of an alternate promoter, compared to variant 1. It encodes isoform 3, which has a distinct and shorter N-terminus, compared to isoform 5.
      Source sequence(s)
      AC015684, AC090662, AC111163, AC113193
      Consensus CDS
      CCDS53612.1
      UniProtKB/TrEMBL
      A7E2D6
      Related
      ENSP00000353871.4, ENST00000360655.8
      Conserved Domains (5) summary
      smart00382
      Location:2027 → 2135
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:22 → 126
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam11235
      Location:151 → 322
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam13401
      Location:2030 → 2117
      AAA_22; AAA domain
      pfam15898
      Location:1784 → 1836
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    2. NM_001111019.3 → NP_001104489.1  neuron navigator 2 isoform 4

      See identical proteins and their annotated locations for NP_001104489.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC015684, AK074287, R23148
      Consensus CDS
      CCDS44552.1
      UniProtKB/Swiss-Prot
      Q8IVL1
      Related
      ENSP00000437316.1, ENST00000533917.5
      Conserved Domains (3) summary
      smart00382
      Location:1155 → 1263
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1158 → 1245
      AAA_22; AAA domain
      pfam15898
      Location:912 → 964
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    3. NM_001244963.2 → NP_001231892.1  neuron navigator 2 isoform 5

      See identical proteins and their annotated locations for NP_001231892.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).
      Source sequence(s)
      AC009549, AC015684, AC090662, AC111163
      Consensus CDS
      CCDS58126.1
      UniProtKB/Swiss-Prot
      A6NEC1, Q8IVK3, Q8IVK4, Q8IVK5, Q8IVK6, Q8IVK7, Q8IVK8, Q8IVL1, Q8NHC9, Q8NHD0, Q8TDE9, Q8TDF0, Q8TEB3, Q96B30, Q9NUZ6, Q9NVM7, Q9P2C8
      UniProtKB/TrEMBL
      A7E2D6
      Related
      ENSP00000379396.3, ENST00000396087.7
      Conserved Domains (4) summary
      smart00382
      Location:2150 → 2258
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:89 → 190
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam13401
      Location:2153 → 2240
      AAA_22; AAA domain
      pfam15898
      Location:1907 → 1959
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    4. NM_145117.5 → NP_660093.2  neuron navigator 2 isoform 2

      See identical proteins and their annotated locations for NP_660093.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks several alternate exons in the coding region, compared to variant 5. This results in a shorter protein (isoform 2), which maintains the reading frame and contains the same N- and C-termimi, compared to isoform 5.
      Source sequence(s)
      AC009549, AC015684, AC090662, AC111163
      Consensus CDS
      CCDS7850.1
      UniProtKB/TrEMBL
      A7E2D6
      Related
      ENSP00000309577.6, ENST00000349880.9
      Conserved Domains (5) summary
      smart00382
      Location:2091 → 2199
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:89 → 190
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam11235
      Location:215 → 386
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam13401
      Location:2094 → 2181
      AAA_22; AAA domain
      pfam15898
      Location:1848 → 1900
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    5. NM_182964.6 → NP_892009.3  neuron navigator 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks several alternate exons in the coding region, compared to variant 5. This results in a shorter protein (isoform 1), which maintains the reading frame and contains the same N- and C-termimi, compared to isoform 5.
      Source sequence(s)
      AC009549, AC015684, AC090662, AC111163
      Consensus CDS
      CCDS7851.2
      UniProtKB/TrEMBL
      A7E2D6
      Related
      ENSP00000379394.1, ENST00000396085.6
      Conserved Domains (5) summary
      smart00382
      Location:2094 → 2202
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:89 → 190
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam11235
      Location:215 → 386
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam13401
      Location:2097 → 2184
      AAA_22; AAA domain
      pfam15898
      Location:1851 → 1903
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      19345236..20121601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018520.3 → XP_016874009.1  neuron navigator 2 isoform X17

      UniProtKB/TrEMBL
      A7E2D6
      Conserved Domains (5) summary
      cd00014
      Location:22 → 126
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam13401
      Location:2084 → 2176
      AAA_22; AAA domain
      cl25496
      Location:245 → 674
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl25732
      Location:1623 → 1895
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28033
      Location:905 → 1257
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    2. XM_047427824.1 → XP_047283780.1  neuron navigator 2 isoform X28

    3. XM_017018522.2 → XP_016874011.1  neuron navigator 2 isoform X24

      UniProtKB/TrEMBL
      A7E2D6

    4. XM_047427828.1 → XP_047283784.1  neuron navigator 2 isoform X32

    5. XM_047427830.1 → XP_047283786.1  neuron navigator 2 isoform X35

    6. XM_047427831.1 → XP_047283787.1  neuron navigator 2 isoform X36

    7. XM_024448758.2 → XP_024304526.1  neuron navigator 2 isoform X17

      UniProtKB/TrEMBL
      A7E2D6
      Conserved Domains (5) summary
      cd00014
      Location:22 → 126
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam13401
      Location:2084 → 2176
      AAA_22; AAA domain
      cl25496
      Location:245 → 674
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl25732
      Location:1623 → 1895
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28033
      Location:905 → 1257
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    8. XM_047427820.1 → XP_047283776.1  neuron navigator 2 isoform X24

    9. XM_047427825.1 → XP_047283781.1  neuron navigator 2 isoform X29

    10. XM_047427833.1 → XP_047283789.1  neuron navigator 2 isoform X36

    11. XM_011520444.4 → XP_011518746.1  neuron navigator 2 isoform X1

      UniProtKB/TrEMBL
      A7E2D6
      Conserved Domains (4) summary
      smart00382
      Location:2147 → 2255
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:89 → 190
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam13401
      Location:2150 → 2237
      AAA_22; AAA domain
      pfam15898
      Location:1904 → 1956
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    12. XM_006718365.5 → XP_006718428.1  neuron navigator 2 isoform X6

      UniProtKB/TrEMBL
      A7E2D6
      Conserved Domains (4) summary
      smart00382
      Location:2117 → 2225
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:89 → 190
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam13401
      Location:2120 → 2207
      AAA_22; AAA domain
      pfam15898
      Location:1874 → 1926
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    13. XM_011520446.4 → XP_011518748.1  neuron navigator 2 isoform X7

      UniProtKB/TrEMBL
      A7E2D6
      Conserved Domains (4) summary
      smart00382
      Location:2114 → 2222
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:89 → 190
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam13401
      Location:2117 → 2204
      AAA_22; AAA domain
      pfam15898
      Location:1871 → 1923
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    14. XM_011520445.4 → XP_011518747.1  neuron navigator 2 isoform X2

      UniProtKB/TrEMBL
      A7E2D6
      Conserved Domains (4) summary
      smart00382
      Location:2128 → 2236
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:89 → 190
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam13401
      Location:2131 → 2218
      AAA_22; AAA domain
      pfam15898
      Location:1885 → 1937
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    15. XM_047427809.1 → XP_047283765.1  neuron navigator 2 isoform X4

    16. XM_047427814.1 → XP_047283770.1  neuron navigator 2 isoform X13

    17. XM_011520449.4 → XP_011518751.1  neuron navigator 2 isoform X14

      UniProtKB/TrEMBL
      A7E2D6
      Conserved Domains (4) summary
      smart00382
      Location:2092 → 2200
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:89 → 190
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam13401
      Location:2095 → 2182
      AAA_22; AAA domain
      pfam15898
      Location:1849 → 1901
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    18. XM_011520447.4 → XP_011518749.1  neuron navigator 2 isoform X8

      UniProtKB/TrEMBL
      A7E2D6
      Conserved Domains (4) summary
      smart00382
      Location:2113 → 2221
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:89 → 190
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam13401
      Location:2116 → 2203
      AAA_22; AAA domain
      pfam15898
      Location:1870 → 1922
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    19. XM_047427811.1 → XP_047283767.1  neuron navigator 2 isoform X9

    20. XM_011520450.4 → XP_011518752.1  neuron navigator 2 isoform X19

      UniProtKB/TrEMBL
      A7E2D6
      Conserved Domains (4) summary
      smart00382
      Location:2080 → 2188
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:89 → 190
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam13401
      Location:2083 → 2170
      AAA_22; AAA domain
      pfam15898
      Location:1837 → 1889
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    21. XM_017018521.3 → XP_016874010.1  neuron navigator 2 isoform X21

      UniProtKB/TrEMBL
      A7E2D6

    22. XM_006718364.5 → XP_006718427.1  neuron navigator 2 isoform X3

      UniProtKB/TrEMBL
      A7E2D6
      Conserved Domains (5) summary
      smart00382
      Location:2127 → 2235
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:89 → 190
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam11235
      Location:215 → 386
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam13401
      Location:2130 → 2217
      AAA_22; AAA domain
      pfam15898
      Location:1884 → 1936
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    23. XM_047427810.1 → XP_047283766.1  neuron navigator 2 isoform X5

    24. XM_047427812.1 → XP_047283768.1  neuron navigator 2 isoform X11

    25. XM_047427813.1 → XP_047283769.1  neuron navigator 2 isoform X12

    26. XM_047427818.1 → XP_047283774.1  neuron navigator 2 isoform X22

    27. XM_047427819.1 → XP_047283775.1  neuron navigator 2 isoform X23

    28. XM_047427815.1 → XP_047283771.1  neuron navigator 2 isoform X15

    29. XM_047427816.1 → XP_047283772.1  neuron navigator 2 isoform X16

    30. XM_047427821.1 → XP_047283777.1  neuron navigator 2 isoform X25

    31. XM_047427823.1 → XP_047283779.1  neuron navigator 2 isoform X27

    32. XM_011520448.4 → XP_011518750.1  neuron navigator 2 isoform X10

      UniProtKB/TrEMBL
      A7E2D6
      Conserved Domains (4) summary
      smart00382
      Location:2107 → 2215
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:46 → 147
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam13401
      Location:2110 → 2197
      AAA_22; AAA domain
      pfam15898
      Location:1864 → 1916
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    33. XM_047427817.1 → XP_047283773.1  neuron navigator 2 isoform X18

    34. XM_017018524.3 → XP_016874013.1  neuron navigator 2 isoform X33

      UniProtKB/TrEMBL
      A7E2D6

    35. XM_006718366.5 → XP_006718429.1  neuron navigator 2 isoform X20

      UniProtKB/TrEMBL
      A7E2D6
      Conserved Domains (4) summary
      smart00382
      Location:2078 → 2186
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:15 → 118
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam13401
      Location:2081 → 2168
      AAA_22; AAA domain
      pfam15898
      Location:1835 → 1887
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    36. XM_047427822.1 → XP_047283778.1  neuron navigator 2 isoform X26

    37. XM_047427829.1 → XP_047283785.1  neuron navigator 2 isoform X34

    38. XM_047427826.1 → XP_047283782.1  neuron navigator 2 isoform X30

    39. XM_047427827.1 → XP_047283783.1  neuron navigator 2 isoform X31

    40. XM_047427834.1 → XP_047283790.1  neuron navigator 2 isoform X37

    41. XM_047427835.1 → XP_047283791.1  neuron navigator 2 isoform X38

    42. XM_047427836.1 → XP_047283792.1  neuron navigator 2 isoform X39

    43. XM_047427837.1 → XP_047283793.1  neuron navigator 2 isoform X40

    44. XM_005253214.5 → XP_005253271.1  neuron navigator 2 isoform X41

      Conserved Domains (3) summary
      smart00382
      Location:1143 → 1251
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1146 → 1233
      AAA_22; AAA domain
      pfam15898
      Location:900 → 952
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    45. XM_047427838.1 → XP_047283794.1  neuron navigator 2 isoform X42

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      19465285..20242238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370387.1 → XP_054226362.1  neuron navigator 2 isoform X17

    2. XM_054370399.1 → XP_054226374.1  neuron navigator 2 isoform X28

    3. XM_054370395.1 → XP_054226370.1  neuron navigator 2 isoform X24

    4. XM_054370403.1 → XP_054226378.1  neuron navigator 2 isoform X32

    5. XM_054370407.1 → XP_054226382.1  neuron navigator 2 isoform X35

    6. XM_054370408.1 → XP_054226383.1  neuron navigator 2 isoform X36

    7. XM_054370394.1 → XP_054226369.1  neuron navigator 2 isoform X24

    8. XM_054370400.1 → XP_054226375.1  neuron navigator 2 isoform X29

    9. XM_054370409.1 → XP_054226384.1  neuron navigator 2 isoform X36

    10. XM_054370388.1 → XP_054226363.1  neuron navigator 2 isoform X18

    11. XM_054370371.1 → XP_054226346.1  neuron navigator 2 isoform X1

    12. XM_054370376.1 → XP_054226351.1  neuron navigator 2 isoform X6

    13. XM_054370377.1 → XP_054226352.1  neuron navigator 2 isoform X7

    14. XM_054370372.1 → XP_054226347.1  neuron navigator 2 isoform X2

    15. XM_054370374.1 → XP_054226349.1  neuron navigator 2 isoform X4

    16. XM_054370383.1 → XP_054226358.1  neuron navigator 2 isoform X13

    17. XM_054370384.1 → XP_054226359.1  neuron navigator 2 isoform X14

    18. XM_054370378.1 → XP_054226353.1  neuron navigator 2 isoform X8

    19. XM_054370379.1 → XP_054226354.1  neuron navigator 2 isoform X9

    20. XM_054370389.1 → XP_054226364.1  neuron navigator 2 isoform X19

    21. XM_054370391.1 → XP_054226366.1  neuron navigator 2 isoform X21

    22. XM_054370373.1 → XP_054226348.1  neuron navigator 2 isoform X3

    23. XM_054370375.1 → XP_054226350.1  neuron navigator 2 isoform X5

    24. XM_054370381.1 → XP_054226356.1  neuron navigator 2 isoform X11

    25. XM_054370382.1 → XP_054226357.1  neuron navigator 2 isoform X12

    26. XM_054370392.1 → XP_054226367.1  neuron navigator 2 isoform X22

    27. XM_054370393.1 → XP_054226368.1  neuron navigator 2 isoform X23

    28. XM_054370385.1 → XP_054226360.1  neuron navigator 2 isoform X15

    29. XM_054370386.1 → XP_054226361.1  neuron navigator 2 isoform X16

    30. XM_054370396.1 → XP_054226371.1  neuron navigator 2 isoform X25

    31. XM_054370398.1 → XP_054226373.1  neuron navigator 2 isoform X27

    32. XM_054370380.1 → XP_054226355.1  neuron navigator 2 isoform X10

    33. XM_054370405.1 → XP_054226380.1  neuron navigator 2 isoform X33

    34. XM_054370390.1 → XP_054226365.1  neuron navigator 2 isoform X20

    35. XM_054370397.1 → XP_054226372.1  neuron navigator 2 isoform X26

    36. XM_054370406.1 → XP_054226381.1  neuron navigator 2 isoform X34

    37. XM_054370401.1 → XP_054226376.1  neuron navigator 2 isoform X30

    38. XM_054370402.1 → XP_054226377.1  neuron navigator 2 isoform X31

    39. XM_054370410.1 → XP_054226385.1  neuron navigator 2 isoform X37

    40. XM_054370411.1 → XP_054226386.1  neuron navigator 2 isoform X38

    41. XM_054370404.1 → XP_054226379.1  neuron navigator 2 isoform X33

    42. XM_054370412.1 → XP_054226387.1  neuron navigator 2 isoform X39

    43. XM_054370413.1 → XP_054226388.1  neuron navigator 2 isoform X40

    44. XM_054370414.1 → XP_054226389.1  neuron navigator 2 isoform X41

    45. XM_054370415.1 → XP_054226390.1  neuron navigator 2 isoform X42

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IVL1.3 GenPept UniProtKB/Swiss-Prot:Q8IVL1

    Gene LinkOut

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