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    MTCL1 microtubule crosslinking factor 1 [ Homo sapiens (human) ]

    Gene ID: 23255, updated on 27-Nov-2024

    Summary

    Official Symbol
    MTCL1provided by HGNC
    Official Full Name
    microtubule crosslinking factor 1provided by HGNC
    Primary source
    HGNC:HGNC:29121
    See related
    Ensembl:ENSG00000168502 MIM:615766; AllianceGenome:HGNC:29121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SOGA2; CCDC165; KIAA0802
    Summary
    Enables microtubule binding activity. Involved in chromosome segregation. Located in kinetochore; midbody; and spindle. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 4.1), gall bladder (RPKM 3.9) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MTCL1 in Genome Data Viewer
    Location:
    18p11.22
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (8705556..8832778)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (8868615..8995758)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (8705554..8832776)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:8614551-8615372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8618188-8618688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8618689-8619189 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:8621915-8622568 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:8622569-8623221 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:8623222-8623874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:8623875-8624527 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:8630542-8631102 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:8635328-8636527 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:8646400-8647022 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:8647023-8647645 Neighboring gene RAB12, member RAS oncogene family Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8657881-8658380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8659695-8660294 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:8662265-8662849 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8690155-8691020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9273 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9274 Neighboring gene NANOG hESC enhancer GRCh37_chr18:8708630-8709131 Neighboring gene TOMM20 pseudogene 3 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:8724358-8724941 Neighboring gene Sharpr-MPRA regulatory region 10096 Neighboring gene gastric cancer associated transcript 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:8766085-8766684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:8766685-8767282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8771566-8772066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8772067-8772567 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:8790509-8791032 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:8800176-8801375 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8818635-8819136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8830462-8830984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8829938-8830461 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8844937-8845437 Neighboring gene MPRA-validated peak3053 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:8948615-8949387 Neighboring gene NANOG hESC enhancer GRCh37_chr18:8977106-8977637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13063 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:8990234-8990766 Neighboring gene NANOG hESC enhancer GRCh37_chr18:8997551-8998052 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:9017064-9018263 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:9022070-9022745 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:9037094-9037241 Neighboring gene ribosomal protein S4X pseudogene 19 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9276 Neighboring gene uncharacterized LOC124904243

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0802

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment or maintenance of epithelial cell apical/basal polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule bundle formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein targeting to membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in apicolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apicolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in lateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in microtubule bundle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule bundle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    microtubule cross-linking factor 1
    Names
    PAR-1-interacting protein
    SOGA family member 2
    coiled-coil domain containing 165
    coiled-coil domain-containing protein 165

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378205.1NP_001365134.1  microtubule cross-linking factor 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AP000864, AP001531
      Consensus CDS
      CCDS92432.1
      UniProtKB/Swiss-Prot
      E9PAY7, Q6ZMQ9, Q8IWA9, Q9Y4B5
      Related
      ENSP00000305027.11, ENST00000306329.16
      Conserved Domains (5) summary
      PHA03247
      Location:12326
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:350729
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:3921278
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11365
      Location:501595
      SOGA; Protein SOGA
      pfam14818
      Location:12281351
      DUF4482; Domain of unknown function (DUF4482)
    2. NM_001378206.1NP_001365135.1  microtubule cross-linking factor 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AP000864, AP001531
      Conserved Domains (5) summary
      PHA03247
      Location:12326
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:350729
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:3921319
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11365
      Location:501595
      SOGA; Protein SOGA
      pfam14818
      Location:12691392
      DUF4482; Domain of unknown function (DUF4482)
    3. NM_001378207.1NP_001365136.1  microtubule cross-linking factor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AP000864, AP001531
      Consensus CDS
      CCDS92433.1
      UniProtKB/TrEMBL
      A0A8Q3SIW6
      Related
      ENSP00000512072.1, ENST00000695635.1
      Conserved Domains (5) summary
      PHA03247
      Location:12326
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:350729
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:3921278
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11365
      Location:501595
      SOGA; Protein SOGA
      pfam14818
      Location:12281351
      DUF4482; Domain of unknown function (DUF4482)
    4. NM_001395220.1NP_001382149.1  microtubule cross-linking factor 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AP000864, AP001531
      Consensus CDS
      CCDS92434.1
      Related
      ENSP00000429556.1, ENST00000517570.5
      Conserved Domains (2) summary
      COG1196
      Location:15369
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:32918
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    5. NM_001395333.1NP_001382262.1  microtubule cross-linking factor 1 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) encodes the longest isoform (6).
      Source sequence(s)
      AP000864, AP001531
      Consensus CDS
      CCDS92431.1
      UniProtKB/TrEMBL
      A0A8Q3WKN6
      Related
      ENSP00000512073.1, ENST00000695636.1
      Conserved Domains (3) summary
      PHA03247
      Location:12326
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:350729
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:3921319
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    6. NM_015210.4NP_056025.2  microtubule cross-linking factor 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AB018345, AK131528, AP000864, AP001531
      Consensus CDS
      CCDS11841.1
      UniProtKB/Swiss-Prot
      Q9Y4B5
      Related
      ENSP00000352927.3, ENST00000359865.7
      Conserved Domains (5) summary
      COG1196
      Location:15296
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:811959
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02463
      Location:1716
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam11365
      Location:141235
      SOGA; Protein SOGA
      pfam14818
      Location:9091032
      DUF4482; Domain of unknown function (DUF4482)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      8705556..8832778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451115.2XP_024306883.2  microtubule cross-linking factor 1 isoform X7

    2. XM_024451110.2XP_024306878.2  microtubule cross-linking factor 1 isoform X1

    3. XM_011525640.4XP_011523942.3  microtubule cross-linking factor 1 isoform X4

    4. XM_024451113.2XP_024306881.2  microtubule cross-linking factor 1 isoform X5

    5. XM_024451117.2XP_024306885.2  microtubule cross-linking factor 1 isoform X9

    6. XM_024451114.2XP_024306882.2  microtubule cross-linking factor 1 isoform X6

    7. XM_047437395.1XP_047293351.1  microtubule cross-linking factor 1 isoform X11

    8. XM_024451118.2XP_024306886.2  microtubule cross-linking factor 1 isoform X12

    9. XM_047437397.1XP_047293353.1  microtubule cross-linking factor 1 isoform X14

    10. XM_024451111.2XP_024306879.2  microtubule cross-linking factor 1 isoform X2

    11. XM_047437396.1XP_047293352.1  microtubule cross-linking factor 1 isoform X13

    12. XM_024451112.2XP_024306880.2  microtubule cross-linking factor 1 isoform X3

    13. XM_047437394.1XP_047293350.1  microtubule cross-linking factor 1 isoform X10

    14. XM_047437399.1XP_047293355.1  microtubule cross-linking factor 1 isoform X16

    15. XM_047437393.1XP_047293349.1  microtubule cross-linking factor 1 isoform X8

    16. XM_047437398.1XP_047293354.1  microtubule cross-linking factor 1 isoform X15

    17. XM_047437400.1XP_047293356.1  microtubule cross-linking factor 1 isoform X17

      UniProtKB/Swiss-Prot
      E9PAY7, Q6ZMQ9, Q8IWA9, Q9Y4B5
    18. XM_024451124.2XP_024306892.2  microtubule cross-linking factor 1 isoform X21

    19. XM_017025671.3XP_016881160.1  microtubule cross-linking factor 1 isoform X18

    20. XM_017025674.3XP_016881163.1  microtubule cross-linking factor 1 isoform X19

      Conserved Domains (3) summary
      pfam11365
      Location:167261
      SOGA; Protein SOGA
      pfam14818
      Location:9731097
      DUF4482; Domain of unknown function (DUF4482)
      cl25732
      Location:16395
      SMC_N; RecF/RecN/SMC N terminal domain
    21. XM_017025672.2XP_016881161.1  microtubule cross-linking factor 1 isoform X19

      Conserved Domains (3) summary
      pfam11365
      Location:167261
      SOGA; Protein SOGA
      pfam14818
      Location:9731097
      DUF4482; Domain of unknown function (DUF4482)
      cl25732
      Location:16395
      SMC_N; RecF/RecN/SMC N terminal domain
    22. XM_047437401.1XP_047293357.1  microtubule cross-linking factor 1 isoform X19

    23. XM_017025673.2XP_016881162.1  microtubule cross-linking factor 1 isoform X19

      Conserved Domains (3) summary
      pfam11365
      Location:167261
      SOGA; Protein SOGA
      pfam14818
      Location:9731097
      DUF4482; Domain of unknown function (DUF4482)
      cl25732
      Location:16395
      SMC_N; RecF/RecN/SMC N terminal domain
    24. XM_024451122.2XP_024306890.1  microtubule cross-linking factor 1 isoform X19

      Conserved Domains (3) summary
      pfam11365
      Location:167261
      SOGA; Protein SOGA
      pfam14818
      Location:9731097
      DUF4482; Domain of unknown function (DUF4482)
      cl25732
      Location:16395
      SMC_N; RecF/RecN/SMC N terminal domain
    25. XM_024451123.2XP_024306891.1  microtubule cross-linking factor 1 isoform X20

      Conserved Domains (3) summary
      pfam11365
      Location:141235
      SOGA; Protein SOGA
      pfam14818
      Location:9061030
      DUF4482; Domain of unknown function (DUF4482)
      cl25732
      Location:15296
      SMC_N; RecF/RecN/SMC N terminal domain
    26. XM_024451125.2XP_024306893.1  microtubule cross-linking factor 1 isoform X22

      Conserved Domains (2) summary
      pfam14818
      Location:277401
      DUF4482; Domain of unknown function (DUF4482)
      cl25732
      Location:141325
      SMC_N; RecF/RecN/SMC N terminal domain
    27. XM_024451126.2XP_024306894.1  microtubule cross-linking factor 1 isoform X22

      Conserved Domains (2) summary
      pfam14818
      Location:277401
      DUF4482; Domain of unknown function (DUF4482)
      cl25732
      Location:141325
      SMC_N; RecF/RecN/SMC N terminal domain

    RNA

    1. XR_002958167.2 RNA Sequence

    2. XR_007066128.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      8868615..8995758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318362.1XP_054174337.1  microtubule cross-linking factor 1 isoform X7

    2. XM_054318356.1XP_054174331.1  microtubule cross-linking factor 1 isoform X1

    3. XM_054318359.1XP_054174334.1  microtubule cross-linking factor 1 isoform X4

    4. XM_054318360.1XP_054174335.1  microtubule cross-linking factor 1 isoform X5

    5. XM_054318364.1XP_054174339.1  microtubule cross-linking factor 1 isoform X9

    6. XM_054318361.1XP_054174336.1  microtubule cross-linking factor 1 isoform X6

    7. XM_054318366.1XP_054174341.1  microtubule cross-linking factor 1 isoform X11

    8. XM_054318367.1XP_054174342.1  microtubule cross-linking factor 1 isoform X12

    9. XM_054318369.1XP_054174344.1  microtubule cross-linking factor 1 isoform X14

    10. XM_054318357.1XP_054174332.1  microtubule cross-linking factor 1 isoform X2

    11. XM_054318368.1XP_054174343.1  microtubule cross-linking factor 1 isoform X13

    12. XM_054318358.1XP_054174333.1  microtubule cross-linking factor 1 isoform X3

    13. XM_054318365.1XP_054174340.1  microtubule cross-linking factor 1 isoform X10

    14. XM_054318371.1XP_054174346.1  microtubule cross-linking factor 1 isoform X16

    15. XM_054318363.1XP_054174338.1  microtubule cross-linking factor 1 isoform X8

    16. XM_054318370.1XP_054174345.1  microtubule cross-linking factor 1 isoform X15

    17. XM_054318372.1XP_054174347.1  microtubule cross-linking factor 1 isoform X17

    18. XM_054318379.1XP_054174354.1  microtubule cross-linking factor 1 isoform X21

    19. XM_054318373.1XP_054174348.1  microtubule cross-linking factor 1 isoform X18

    20. XM_054318377.1XP_054174352.1  microtubule cross-linking factor 1 isoform X19

    21. XM_054318375.1XP_054174350.1  microtubule cross-linking factor 1 isoform X19

    22. XM_054318376.1XP_054174351.1  microtubule cross-linking factor 1 isoform X19

    23. XM_054318374.1XP_054174349.1  microtubule cross-linking factor 1 isoform X19

    24. XM_054318378.1XP_054174353.1  microtubule cross-linking factor 1 isoform X20

    25. XM_054318380.1XP_054174355.1  microtubule cross-linking factor 1 isoform X22

    26. XM_054318381.1XP_054174356.1  microtubule cross-linking factor 1 isoform X22

    RNA

    1. XR_008484987.1 RNA Sequence

    2. XR_008484988.1 RNA Sequence