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    ZNF841 zinc finger protein 841 [ Homo sapiens (human) ]

    Gene ID: 284371, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF841provided by HGNC
    Official Full Name
    zinc finger protein 841provided by HGNC
    Primary source
    HGNC:HGNC:27611
    See related
    Ensembl:ENSG00000197608 AllianceGenome:HGNC:27611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in prostate (RPKM 3.7), endometrium (RPKM 2.9) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF841 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52058095..52095765, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55145315..55182977, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52561348..52599018, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 614 Neighboring gene uncharacterized LOC112268244 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:52530119-52530889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15034 Neighboring gene zinc finger protein 432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15035 Neighboring gene zinc finger protein 160 pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:52568267-52569466 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:52573383-52574582 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51593 Neighboring gene zinc finger protein 616 Neighboring gene uncharacterized LOC124904799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10992 Neighboring gene ribosomal protein L37 pseudogene 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics. Wu AC, et al. J Allergy Clin Immunol, 2014 Mar. PMID 24280104, Free PMC Article
    2. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    3. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. Antoniali G, et al. Nat Commun, 2017 Oct 6. PMID 28986522, Free PMC Article
    4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197
    5. Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease. Viard J, et al. Life Sci Alliance, 2022 Aug 1. PMID 35914814, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 841

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136499.2 → NP_001129971.1  zinc finger protein 841 isoform 1

      See identical proteins and their annotated locations for NP_001129971.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), as well as variants 3, 6, 7, and 8, encodes isoform 1.
      Source sequence(s)
      AC011468
      Consensus CDS
      CCDS46161.1
      UniProtKB/Swiss-Prot
      Q6ZN19
      Related
      ENSP00000470100.2, ENST00000594440.6
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:483 → 885
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:459 → 479
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001321349.2 → NP_001308278.1  zinc finger protein 841 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variant 10, encodes isoform 2.
      Source sequence(s)
      AC011468, AK131409
      Consensus CDS
      CCDS82388.1
      UniProtKB/Swiss-Prot
      B9EG58, Q6ZN19, Q6ZN82, Q6ZP71, Q8N9U7
      Related
      ENSP00000415453.2, ENST00000426391.6
      Conserved Domains (2) summary
      COG5048
      Location:367 → 769
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:343 → 363
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001352298.2 → NP_001339227.1  zinc finger protein 841 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 1, 6, 7, and 8, encodes isoform 1.
      Source sequence(s)
      AC011468, AK131409, CN283320
      Consensus CDS
      CCDS46161.1
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:483 → 885
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:459 → 479
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001352299.2 → NP_001339228.1  zinc finger protein 841 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC011468, BF512443, CN283320, DB333163
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:342 → 755
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:459 → 479
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:752 → 776
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001369825.1 → NP_001356754.1  zinc finger protein 841 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) encodes the longest isoform (4).
      Source sequence(s)
      AC011468
      Conserved Domains (3) summary
      smart00349
      Location:8 → 69
      KRAB; krueppel associated box
      COG5048
      Location:484 → 886
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:460 → 480
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001369826.1 → NP_001356755.1  zinc finger protein 841 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 3, 7, and 8, encodes isoform 1.
      Source sequence(s)
      AC011468
      Consensus CDS
      CCDS46161.1
      Related
      ENSP00000374185.4, ENST00000389534.8
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:483 → 885
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:459 → 479
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001369827.1 → NP_001356756.1  zinc finger protein 841 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 1, 3, 6, and 8, encodes isoform 1.
      Source sequence(s)
      AC011468
      Consensus CDS
      CCDS46161.1
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:483 → 885
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:459 → 479
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. NM_001369828.1 → NP_001356757.1  zinc finger protein 841 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 1, 3, 6, and 7, encodes isoform 1.
      Source sequence(s)
      AC011468
      Consensus CDS
      CCDS46161.1
      Related
      ENSP00000470746.1, ENST00000594295.5
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:483 → 885
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:459 → 479
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. NM_001369829.2 → NP_001356758.1  zinc finger protein 841 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC011468
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:342 → 755
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:459 → 479
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:752 → 776
      zf-H2C2_2; Zinc-finger double domain

    10. NM_001369830.1 → NP_001356759.1  zinc finger protein 841 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC011468
      Consensus CDS
      CCDS82388.1
      UniProtKB/Swiss-Prot
      B9EG58, Q6ZN19, Q6ZN82, Q6ZP71, Q8N9U7
      Conserved Domains (2) summary
      COG5048
      Location:367 → 769
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:343 → 363
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      52058095..52095765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438655.1 → XP_047294611.1  zinc finger protein 841 isoform X2

    2. XM_047438652.1 → XP_047294608.1  zinc finger protein 841 isoform X1

    3. XM_047438653.1 → XP_047294609.1  zinc finger protein 841 isoform X2

    4. XM_017026653.2 → XP_016882142.1  zinc finger protein 841 isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:8 → 69
      KRAB; krueppel associated box
      COG5048
      Location:484 → 886
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:460 → 480
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_047438651.1 → XP_047294607.1  zinc finger protein 841 isoform X1

    6. XM_047438654.1 → XP_047294610.1  zinc finger protein 841 isoform X2

    7. XM_047438650.1 → XP_047294606.1  zinc finger protein 841 isoform X1

    8. XM_047438649.1 → XP_047294605.1  zinc finger protein 841 isoform X1

    9. XM_047438656.1 → XP_047294612.1  zinc finger protein 841 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      55145315..55182977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320656.1 → XP_054176631.1  zinc finger protein 841 isoform X2

    2. XM_054320653.1 → XP_054176628.1  zinc finger protein 841 isoform X1

    3. XM_054320654.1 → XP_054176629.1  zinc finger protein 841 isoform X2

    4. XM_054320649.1 → XP_054176624.1  zinc finger protein 841 isoform X1

    5. XM_054320652.1 → XP_054176627.1  zinc finger protein 841 isoform X1

    6. XM_054320655.1 → XP_054176630.1  zinc finger protein 841 isoform X2

    7. XM_054320651.1 → XP_054176626.1  zinc finger protein 841 isoform X1

    8. XM_054320650.1 → XP_054176625.1  zinc finger protein 841 isoform X1

    9. XM_054320657.1 → XP_054176632.1  zinc finger protein 841 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZN19.1 GenPept UniProtKB/Swiss-Prot:Q6ZN19

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