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    SETD5 SET domain containing 5 [ Homo sapiens (human) ]

    Gene ID: 55209, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SETD5provided by HGNC
    Official Full Name
    SET domain containing 5provided by HGNC
    Primary source
    HGNC:HGNC:25566
    See related
    Ensembl:ENSG00000168137 MIM:615743; AllianceGenome:HGNC:25566
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRD23; SETD5A
    Summary
    This function of this gene has yet to be determined but based on sequence similarity to other SET domain proteins it may function as a histone methyltransferase. Mutations in this gene have been associated with an autosomal dominant form of intellectual disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]
    Expression
    Ubiquitous expression in brain (RPKM 9.1), thyroid (RPKM 9.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SETD5 in Genome Data Viewer
    Location:
    3p25.3
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (9397615..9478154)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (9389553..9470070)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9439299..9519838)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SLIT-ROBO Rho GTPase activating protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19399 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19401 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19402 Neighboring gene phosphoglycerate mutase 1 pseudogene 4 Neighboring gene THUMPD3 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19403 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:9444537-9445037 Neighboring gene Sharpr-MPRA regulatory region 11896 Neighboring gene THUMP domain containing 3 Neighboring gene MPRA-validated peak4533 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:9543010-9543735 Neighboring gene Sharpr-MPRA regulatory region 15302 Neighboring gene LHFPL tetraspan subfamily member 4 Neighboring gene uncharacterized LOC105376949

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SET domain containing protein 5 (SETD5) enhances tumor cell invasion and is associated with a poor prognosis in non-small cell lung cancer patients. Yu H, et al. BMC Cancer, 2019 Jul 25. PMID 31345185, Free PMC Article
    2. Structure, activity and function of the lysine methyltransferase SETD5. Li M, et al. Front Endocrinol (Lausanne), 2023. PMID 36875494, Free PMC Article
    3. Genetic variations on SETD5 underlying autistic conditions. Fernandes IR, et al. Dev Neurobiol, 2018 May. PMID 29484850
    4. De novo loss-of-function mutations in SETD5, encoding a methyltransferase in a 3p25 microdeletion syndrome critical region, cause intellectual disability. Grozeva D, et al. Am J Hum Genet, 2014 Apr 3. PMID 24680889, Free PMC Article
    5. Expansion and further delineation of the SETD5 phenotype leading to global developmental delay, variable dysmorphic features, and reduced penetrance. Powis Z, et al. Clin Genet, 2018 Apr. PMID 28881385

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SETD5 haploinsufficiency affects mitochondrial compartment in neural cells.
      Title: SETD5 haploinsufficiency affects mitochondrial compartment in neural cells.
    2. Structure, activity and function of the lysine methyltransferase SETD5.
      Title: Structure, activity and function of the lysine methyltransferase SETD5.
    3. SETD5 Regulates Glycolysis in Breast Cancer Stem-Like Cells and Fuels Tumor Growth.
      Title: SETD5 Regulates Glycolysis in Breast Cancer Stem-Like Cells and Fuels Tumor Growth.
    4. SET Domain-Containing Protein 5 Enhances the Cell Stemness of Non-Small Cell Lung Cancer via the PI3K/Akt/mTOR Pathway.
      Title: SET Domain-Containing Protein 5 Enhances the Cell Stemness of Non-Small Cell Lung Cancer via the PI3K/Akt/mTOR Pathway.
    5. The pleiotropy associated with de novo variants in CHD4, CNOT3, and SETD5 extends to moyamoya angiopathy.
      Title: The pleiotropy associated with de novo variants in CHD4, CNOT3, and SETD5 extends to moyamoya angiopathy.
    6. Su(var)3-9, Enhancer of Zeste, and Trithorax Domain-Containing 5 Facilitates Tumor Growth and Pulmonary Metastasis through Up-Regulation of AKT1 Signaling in Breast Cancer.
      Title: Su(var)3-9, Enhancer of Zeste, and Trithorax Domain-Containing 5 Facilitates Tumor Growth and Pulmonary Metastasis through Up-Regulation of AKT1 Signaling in Breast Cancer.
    7. SET domain-containing 5 is a potential prognostic biomarker that promotes esophageal squamous cell carcinoma stemness.
      Title: SET domain-containing 5 is a potential prognostic biomarker that promotes esophageal squamous cell carcinoma stemness.
    8. Study results suggest that SETD5 could regulate p-P90RSK and facilitate the migration and invasion of non-small cell lung cancer (NSCLC) and may be related to the poor prognosis of patients with NSCLC.
      Title: SET domain containing protein 5 (SETD5) enhances tumor cell invasion and is associated with a poor prognosis in non-small cell lung cancer patients.
    9. We suggest that the phenotype of SETD5 is more complex and variable than previously presented. Therefore, many features and presentations need to be considered when evaluating a patient for SETD5 alterations through Diagnostic exome sequencing .
      Title: Expansion and further delineation of the SETD5 phenotype leading to global developmental delay, variable dysmorphic features, and reduced penetrance.
    10. These co-occurring hits involved known disease-associated genes such as SETD5, AUTS2, and NRXN1, and were enriched for cellular and developmental processes. Accurate genetic diagnosis of complex disorders will require complete evaluation of the genetic background even after a candidate disease-associated variant is identified
      Title: Rare variants in the genetic background modulate cognitive and developmental phenotypes in individuals carrying disease-associated variants.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Intellectual disability-facial dysmorphism syndrome due to SETD5 haploinsufficiency
    MedGen: C3810406 OMIM: 615761 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2014-11-06)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2014-11-06)

    ClinGen Genome Curation PagePubMed

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10707, KIAA1757, DKFZp686J18276

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone H3K36 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H3K36 trimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H3K9 monomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9me2 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cognition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of chromatin organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Rpd3L-Expanded complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in euchromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase SETD5
    Names
    SET domain-containing protein 5
    NP_001073986.1
    NP_001278972.1
    NP_001336380.1
    XP_005265358.1
    XP_011532224.1
    XP_011532230.1
    XP_011532235.1
    XP_016862260.1
    XP_016862263.1
    XP_047304422.1
    XP_047304423.1
    XP_047304424.1
    XP_047304425.1
    XP_047304426.1
    XP_047304427.1
    XP_047304428.1
    XP_047304429.1
    XP_047304430.1
    XP_047304431.1
    XP_047304432.1
    XP_047304433.1
    XP_047304434.1
    XP_047304435.1
    XP_047304436.1
    XP_047304437.1
    XP_047304438.1
    XP_047304439.1
    XP_047304440.1
    XP_047304441.1
    XP_047304442.1
    XP_047304443.1
    XP_047304444.1
    XP_047304445.1
    XP_047304446.1
    XP_047304447.1
    XP_047304448.1
    XP_047304449.1
    XP_047304450.1
    XP_047304451.1
    XP_047304452.1
    XP_047304453.1
    XP_047304454.1
    XP_047304455.1
    XP_047304456.1
    XP_047304457.1
    XP_047304458.1
    XP_047304459.1
    XP_047304460.1
    XP_047304461.1
    XP_047304462.1
    XP_047304463.1
    XP_047304464.1
    XP_054203082.1
    XP_054203083.1
    XP_054203084.1
    XP_054203085.1
    XP_054203086.1
    XP_054203087.1
    XP_054203088.1
    XP_054203089.1
    XP_054203090.1
    XP_054203091.1
    XP_054203092.1
    XP_054203093.1
    XP_054203094.1
    XP_054203095.1
    XP_054203096.1
    XP_054203097.1
    XP_054203098.1
    XP_054203099.1
    XP_054203100.1
    XP_054203101.1
    XP_054203102.1
    XP_054203103.1
    XP_054203104.1
    XP_054203105.1
    XP_054203106.1
    XP_054203107.1
    XP_054203108.1
    XP_054203109.1
    XP_054203110.1
    XP_054203111.1
    XP_054203112.1
    XP_054203113.1
    XP_054203114.1
    XP_054203115.1
    XP_054203116.1
    XP_054203117.1
    XP_054203118.1
    XP_054203119.1
    XP_054203120.1
    XP_054203121.1
    XP_054203122.1
    XP_054203123.1
    XP_054203124.1
    XP_054203125.1
    XP_054203126.1
    XP_054203127.1
    XP_054203128.1
    XP_054203129.1
    XP_054203130.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034132.1 RefSeqGene

      Range
      4916..85455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001080517.3 → NP_001073986.1  histone-lysine N-methyltransferase SETD5 isoform 1

      See identical proteins and their annotated locations for NP_001073986.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AB051544, AC018506, AI243838, AK092046, CR627408
      Consensus CDS
      CCDS46741.1
      UniProtKB/Swiss-Prot
      Q6AI17, Q8WUB6, Q9C0A6, Q9H3X4, Q9H6V7, Q9H7S3, Q9NVI9
      UniProtKB/TrEMBL
      B3KRD6
      Related
      ENSP00000385852.2, ENST00000402198.7
      Conserved Domains (1) summary
      smart00317
      Location:286 → 395
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    2. NM_001292043.2 → NP_001278972.1  histone-lysine N-methyltransferase SETD5 isoform 2

      See identical proteins and their annotated locations for NP_001278972.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon structure and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
      Source sequence(s)
      AB051544, AC018506, AI243838, AK092046, AW021954, CR627408, DB275141
      UniProtKB/TrEMBL
      B3KRD6
      Conserved Domains (2) summary
      smart00317
      Location:188 → 297
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cl27032
      Location:336 → 556
      Utp14; Utp14 protein

    3. NM_001349451.2 → NP_001336380.1  histone-lysine N-methyltransferase SETD5 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' exon structure and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
      Source sequence(s)
      AC018506
      UniProtKB/TrEMBL
      B3KRD6
      Conserved Domains (2) summary
      smart00317
      Location:188 → 297
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cl27032
      Location:336 → 556
      Utp14; Utp14 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      9397615..9478154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448468.1 → XP_047304424.1  histone-lysine N-methyltransferase SETD5 isoform X1

      UniProtKB/TrEMBL
      B3KRD6

    2. XM_047448473.1 → XP_047304429.1  histone-lysine N-methyltransferase SETD5 isoform X2

      UniProtKB/TrEMBL
      B3KRD6

    3. XM_047448482.1 → XP_047304438.1  histone-lysine N-methyltransferase SETD5 isoform X7

      UniProtKB/TrEMBL
      A0A804HKJ9, B3KRD6

    4. XM_047448487.1 → XP_047304443.1  histone-lysine N-methyltransferase SETD5 isoform X12

      UniProtKB/TrEMBL
      B3KRD6, E7EWN3

    5. XM_047448489.1 → XP_047304445.1  histone-lysine N-methyltransferase SETD5 isoform X13

      UniProtKB/TrEMBL
      B3KRD6

    6. XM_047448496.1 → XP_047304452.1  histone-lysine N-methyltransferase SETD5 isoform X18

      UniProtKB/Swiss-Prot
      Q6AI17, Q8WUB6, Q9C0A6, Q9H3X4, Q9H6V7, Q9H7S3, Q9NVI9
      UniProtKB/TrEMBL
      B3KRD6

    7. XM_047448474.1 → XP_047304430.1  histone-lysine N-methyltransferase SETD5 isoform X2

      UniProtKB/TrEMBL
      B3KRD6

    8. XM_047448481.1 → XP_047304437.1  histone-lysine N-methyltransferase SETD5 isoform X7

      UniProtKB/TrEMBL
      A0A804HKJ9, B3KRD6

    9. XM_047448479.1 → XP_047304435.1  histone-lysine N-methyltransferase SETD5 isoform X6

      UniProtKB/TrEMBL
      B3KRD6

    10. XM_047448488.1 → XP_047304444.1  histone-lysine N-methyltransferase SETD5 isoform X12

      UniProtKB/TrEMBL
      B3KRD6, E7EWN3

    11. XM_047448490.1 → XP_047304446.1  histone-lysine N-methyltransferase SETD5 isoform X13

      UniProtKB/TrEMBL
      B3KRD6

    12. XM_047448497.1 → XP_047304453.1  histone-lysine N-methyltransferase SETD5 isoform X18

      UniProtKB/Swiss-Prot
      Q6AI17, Q8WUB6, Q9C0A6, Q9H3X4, Q9H6V7, Q9H7S3, Q9NVI9
      UniProtKB/TrEMBL
      B3KRD6

    13. XM_047448466.1 → XP_047304422.1  histone-lysine N-methyltransferase SETD5 isoform X1

      UniProtKB/TrEMBL
      B3KRD6

    14. XM_047448477.1 → XP_047304433.1  histone-lysine N-methyltransferase SETD5 isoform X4

      UniProtKB/TrEMBL
      B3KRD6

    15. XM_047448483.1 → XP_047304439.1  histone-lysine N-methyltransferase SETD5 isoform X9

      UniProtKB/TrEMBL
      B3KRD6

    16. XM_047448478.1 → XP_047304434.1  histone-lysine N-methyltransferase SETD5 isoform X5

      UniProtKB/TrEMBL
      B3KRD6

    17. XM_047448486.1 → XP_047304442.1  histone-lysine N-methyltransferase SETD5 isoform X11

      UniProtKB/TrEMBL
      B3KRD6

    18. XM_047448485.1 → XP_047304441.1  histone-lysine N-methyltransferase SETD5 isoform X10

      UniProtKB/TrEMBL
      B3KRD6

    19. XM_047448495.1 → XP_047304451.1  histone-lysine N-methyltransferase SETD5 isoform X17

      UniProtKB/TrEMBL
      B3KRD6

    20. XM_047448476.1 → XP_047304432.1  histone-lysine N-methyltransferase SETD5 isoform X3

      UniProtKB/TrEMBL
      B3KRD6

    21. XM_011533922.2 → XP_011532224.1  histone-lysine N-methyltransferase SETD5 isoform X2

      See identical proteins and their annotated locations for XP_011532224.1

      UniProtKB/TrEMBL
      B3KRD6
      Conserved Domains (3) summary
      PLN02217
      Location:1353 → 1460
      PLN02217; probable pectinesterase/pectinesterase inhibitor
      COG5644
      Location:466 → 686
      COG5644; U3 small nucleolar RNA-associated protein 14 [Function unknown]
      cd19181
      Location:298 → 447
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins

    22. XM_047448480.1 → XP_047304436.1  histone-lysine N-methyltransferase SETD5 isoform X7

      UniProtKB/TrEMBL
      A0A804HKJ9, B3KRD6
      Related
      ENSP00000507956.1, ENST00000682536.1

    23. XM_017006771.2 → XP_016862260.1  histone-lysine N-methyltransferase SETD5 isoform X6

      UniProtKB/TrEMBL
      B3KRD6
      Conserved Domains (3) summary
      PLN02217
      Location:1340 → 1447
      PLN02217; probable pectinesterase/pectinesterase inhibitor
      COG5644
      Location:453 → 673
      COG5644; U3 small nucleolar RNA-associated protein 14 [Function unknown]
      cd19181
      Location:285 → 434
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins

    24. XM_005265301.2 → XP_005265358.1  histone-lysine N-methyltransferase SETD5 isoform X12

      UniProtKB/TrEMBL
      B3KRD6, E7EWN3
      Related
      ENSP00000384114.1, ENST00000407969.5
      Conserved Domains (3) summary
      PLN02217
      Location:1321 → 1428
      PLN02217; probable pectinesterase/pectinesterase inhibitor
      COG5644
      Location:453 → 673
      COG5644; U3 small nucleolar RNA-associated protein 14 [Function unknown]
      cd19181
      Location:285 → 434
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins

    25. XM_011533928.2 → XP_011532230.1  histone-lysine N-methyltransferase SETD5 isoform X8

      UniProtKB/TrEMBL
      B3KRD6
      Conserved Domains (3) summary
      PLN02217
      Location:1334 → 1441
      PLN02217; probable pectinesterase/pectinesterase inhibitor
      COG5644
      Location:447 → 667
      COG5644; U3 small nucleolar RNA-associated protein 14 [Function unknown]
      cd19181
      Location:279 → 428
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins

    26. XM_047448492.1 → XP_047304448.1  histone-lysine N-methyltransferase SETD5 isoform X15

      UniProtKB/TrEMBL
      B3KRD6

    27. XM_017006774.2 → XP_016862263.1  histone-lysine N-methyltransferase SETD5 isoform X13

      UniProtKB/TrEMBL
      B3KRD6
      Conserved Domains (3) summary
      PLN02217
      Location:1321 → 1428
      PLN02217; probable pectinesterase/pectinesterase inhibitor
      COG5644
      Location:434 → 654
      COG5644; U3 small nucleolar RNA-associated protein 14 [Function unknown]
      cd19181
      Location:266 → 415
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins

    28. XM_047448500.1 → XP_047304456.1  histone-lysine N-methyltransferase SETD5 isoform X22

      UniProtKB/TrEMBL
      B3KRD6

    29. XM_047448501.1 → XP_047304457.1  histone-lysine N-methyltransferase SETD5 isoform X23

      UniProtKB/TrEMBL
      B3KRD6

    30. XM_047448503.1 → XP_047304459.1  histone-lysine N-methyltransferase SETD5 isoform X25

      UniProtKB/TrEMBL
      B3KRD6

    31. XM_047448504.1 → XP_047304460.1  histone-lysine N-methyltransferase SETD5 isoform X26

      UniProtKB/TrEMBL
      B3KRD6

    32. XM_047448502.1 → XP_047304458.1  histone-lysine N-methyltransferase SETD5 isoform X24

      UniProtKB/TrEMBL
      B3KRD6

    33. XM_047448505.1 → XP_047304461.1  histone-lysine N-methyltransferase SETD5 isoform X27

      UniProtKB/TrEMBL
      B3KRD6

    34. XM_047448506.1 → XP_047304462.1  histone-lysine N-methyltransferase SETD5 isoform X28

      UniProtKB/TrEMBL
      A0A804HKJ6
      Related
      ENSP00000507953.1, ENST00000684055.1

    35. XM_047448507.1 → XP_047304463.1  histone-lysine N-methyltransferase SETD5 isoform X29

      UniProtKB/TrEMBL
      A0A804HKJ6

    36. XM_047448508.1 → XP_047304464.1  histone-lysine N-methyltransferase SETD5 isoform X30

      UniProtKB/TrEMBL
      A0A804HKJ6

    37. XM_047448491.1 → XP_047304447.1  histone-lysine N-methyltransferase SETD5 isoform X14

      UniProtKB/TrEMBL
      B3KRD6

    38. XM_047448470.1 → XP_047304426.1  histone-lysine N-methyltransferase SETD5 isoform X1

      UniProtKB/TrEMBL
      B3KRD6

    39. XM_047448469.1 → XP_047304425.1  histone-lysine N-methyltransferase SETD5 isoform X1

      UniProtKB/TrEMBL
      B3KRD6

    40. XM_047448484.1 → XP_047304440.1  histone-lysine N-methyltransferase SETD5 isoform X10

      UniProtKB/TrEMBL
      B3KRD6

    41. XM_047448494.1 → XP_047304450.1  histone-lysine N-methyltransferase SETD5 isoform X16

      UniProtKB/TrEMBL
      B3KRD6

    42. XM_047448498.1 → XP_047304454.1  histone-lysine N-methyltransferase SETD5 isoform X19

      UniProtKB/TrEMBL
      B3KRD6

    43. XM_047448472.1 → XP_047304428.1  histone-lysine N-methyltransferase SETD5 isoform X1

      UniProtKB/TrEMBL
      B3KRD6

    44. XM_047448475.1 → XP_047304431.1  histone-lysine N-methyltransferase SETD5 isoform X2

      UniProtKB/TrEMBL
      B3KRD6

    45. XM_047448467.1 → XP_047304423.1  histone-lysine N-methyltransferase SETD5 isoform X1

      UniProtKB/TrEMBL
      B3KRD6

    46. XM_047448493.1 → XP_047304449.1  histone-lysine N-methyltransferase SETD5 isoform X15

      UniProtKB/TrEMBL
      B3KRD6

    47. XM_047448471.1 → XP_047304427.1  histone-lysine N-methyltransferase SETD5 isoform X1

      UniProtKB/TrEMBL
      B3KRD6

    48. XM_047448499.1 → XP_047304455.1  histone-lysine N-methyltransferase SETD5 isoform X20

      UniProtKB/TrEMBL
      B3KRD6

    49. XM_011533933.2 → XP_011532235.1  histone-lysine N-methyltransferase SETD5 isoform X21

      See identical proteins and their annotated locations for XP_011532235.1

      UniProtKB/TrEMBL
      B3KRD6
      Conserved Domains (3) summary
      PLN02217
      Location:1210 → 1317
      PLN02217; probable pectinesterase/pectinesterase inhibitor
      COG5644
      Location:323 → 543
      COG5644; U3 small nucleolar RNA-associated protein 14 [Function unknown]
      cd19181
      Location:155 → 304
      SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      9389553..9470070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347108.1 → XP_054203083.1  histone-lysine N-methyltransferase SETD5 isoform X1

      UniProtKB/TrEMBL
      B3KRD6

    2. XM_054347114.1 → XP_054203089.1  histone-lysine N-methyltransferase SETD5 isoform X2

      UniProtKB/TrEMBL
      B3KRD6

    3. XM_054347125.1 → XP_054203100.1  histone-lysine N-methyltransferase SETD5 isoform X7

      UniProtKB/TrEMBL
      A0A804HKJ9, B3KRD6

    4. XM_054347115.1 → XP_054203090.1  histone-lysine N-methyltransferase SETD5 isoform X2

      UniProtKB/TrEMBL
      B3KRD6

    5. XM_054347124.1 → XP_054203099.1  histone-lysine N-methyltransferase SETD5 isoform X7

      UniProtKB/TrEMBL
      A0A804HKJ9, B3KRD6

    6. XM_054347121.1 → XP_054203096.1  histone-lysine N-methyltransferase SETD5 isoform X6

      UniProtKB/TrEMBL
      B3KRD6

    7. XM_054347133.1 → XP_054203108.1  histone-lysine N-methyltransferase SETD5 isoform X12

      UniProtKB/TrEMBL
      B3KRD6, E7EWN3

    8. XM_054347135.1 → XP_054203110.1  histone-lysine N-methyltransferase SETD5 isoform X13

      UniProtKB/TrEMBL
      B3KRD6

    9. XM_054347143.1 → XP_054203118.1  histone-lysine N-methyltransferase SETD5 isoform X18

      UniProtKB/Swiss-Prot
      Q6AI17, Q8WUB6, Q9C0A6, Q9H3X4, Q9H6V7, Q9H7S3, Q9NVI9
      UniProtKB/TrEMBL
      B3KRD6

    10. XM_054347107.1 → XP_054203082.1  histone-lysine N-methyltransferase SETD5 isoform X1

      UniProtKB/TrEMBL
      B3KRD6

    11. XM_054347118.1 → XP_054203093.1  histone-lysine N-methyltransferase SETD5 isoform X4

      UniProtKB/TrEMBL
      B3KRD6

    12. XM_054347127.1 → XP_054203102.1  histone-lysine N-methyltransferase SETD5 isoform X9

      UniProtKB/TrEMBL
      B3KRD6

    13. XM_054347119.1 → XP_054203094.1  histone-lysine N-methyltransferase SETD5 isoform X5

      UniProtKB/TrEMBL
      B3KRD6

    14. XM_054347130.1 → XP_054203105.1  histone-lysine N-methyltransferase SETD5 isoform X11

      UniProtKB/TrEMBL
      B3KRD6

    15. XM_054347129.1 → XP_054203104.1  histone-lysine N-methyltransferase SETD5 isoform X10

      UniProtKB/TrEMBL
      B3KRD6

    16. XM_054347141.1 → XP_054203116.1  histone-lysine N-methyltransferase SETD5 isoform X17

      UniProtKB/TrEMBL
      B3KRD6

    17. XM_054347117.1 → XP_054203092.1  histone-lysine N-methyltransferase SETD5 isoform X3

      UniProtKB/TrEMBL
      B3KRD6

    18. XM_054347113.1 → XP_054203088.1  histone-lysine N-methyltransferase SETD5 isoform X2

      UniProtKB/TrEMBL
      B3KRD6

    19. XM_054347123.1 → XP_054203098.1  histone-lysine N-methyltransferase SETD5 isoform X7

      UniProtKB/TrEMBL
      A0A804HKJ9, B3KRD6

    20. XM_054347120.1 → XP_054203095.1  histone-lysine N-methyltransferase SETD5 isoform X6

      UniProtKB/TrEMBL
      B3KRD6

    21. XM_054347131.1 → XP_054203106.1  histone-lysine N-methyltransferase SETD5 isoform X12

      UniProtKB/TrEMBL
      B3KRD6, E7EWN3

    22. XM_054347126.1 → XP_054203101.1  histone-lysine N-methyltransferase SETD5 isoform X8

      UniProtKB/TrEMBL
      B3KRD6

    23. XM_054347138.1 → XP_054203113.1  histone-lysine N-methyltransferase SETD5 isoform X15

      UniProtKB/TrEMBL
      B3KRD6

    24. XM_054347134.1 → XP_054203109.1  histone-lysine N-methyltransferase SETD5 isoform X13

      UniProtKB/TrEMBL
      B3KRD6

    25. XM_054347147.1 → XP_054203122.1  histone-lysine N-methyltransferase SETD5 isoform X22

      UniProtKB/TrEMBL
      B3KRD6

    26. XM_054347148.1 → XP_054203123.1  histone-lysine N-methyltransferase SETD5 isoform X23

      UniProtKB/TrEMBL
      B3KRD6

    27. XM_054347150.1 → XP_054203125.1  histone-lysine N-methyltransferase SETD5 isoform X25

      UniProtKB/TrEMBL
      B3KRD6

    28. XM_054347151.1 → XP_054203126.1  histone-lysine N-methyltransferase SETD5 isoform X26

      UniProtKB/TrEMBL
      B3KRD6

    29. XM_054347149.1 → XP_054203124.1  histone-lysine N-methyltransferase SETD5 isoform X24

      UniProtKB/TrEMBL
      B3KRD6

    30. XM_054347152.1 → XP_054203127.1  histone-lysine N-methyltransferase SETD5 isoform X27

      UniProtKB/TrEMBL
      B3KRD6

    31. XM_054347153.1 → XP_054203128.1  histone-lysine N-methyltransferase SETD5 isoform X28

      UniProtKB/TrEMBL
      A0A804HKJ6

    32. XM_054347154.1 → XP_054203129.1  histone-lysine N-methyltransferase SETD5 isoform X29

      UniProtKB/TrEMBL
      A0A804HKJ6

    33. XM_054347155.1 → XP_054203130.1  histone-lysine N-methyltransferase SETD5 isoform X30

      UniProtKB/TrEMBL
      A0A804HKJ6

    34. XM_054347116.1 → XP_054203091.1  histone-lysine N-methyltransferase SETD5 isoform X2

      UniProtKB/TrEMBL
      B3KRD6

    35. XM_054347137.1 → XP_054203112.1  histone-lysine N-methyltransferase SETD5 isoform X14

      UniProtKB/TrEMBL
      B3KRD6

    36. XM_054347110.1 → XP_054203085.1  histone-lysine N-methyltransferase SETD5 isoform X1

      UniProtKB/TrEMBL
      B3KRD6

    37. XM_054347109.1 → XP_054203084.1  histone-lysine N-methyltransferase SETD5 isoform X1

      UniProtKB/TrEMBL
      B3KRD6

    38. XM_054347140.1 → XP_054203115.1  histone-lysine N-methyltransferase SETD5 isoform X16

      UniProtKB/TrEMBL
      B3KRD6

    39. XM_054347112.1 → XP_054203087.1  histone-lysine N-methyltransferase SETD5 isoform X1

      UniProtKB/TrEMBL
      B3KRD6

    40. XM_054347122.1 → XP_054203097.1  histone-lysine N-methyltransferase SETD5 isoform X6

      UniProtKB/TrEMBL
      B3KRD6

    41. XM_054347139.1 → XP_054203114.1  histone-lysine N-methyltransferase SETD5 isoform X15

      UniProtKB/TrEMBL
      B3KRD6

    42. XM_054347136.1 → XP_054203111.1  histone-lysine N-methyltransferase SETD5 isoform X13

      UniProtKB/TrEMBL
      B3KRD6

    43. XM_054347128.1 → XP_054203103.1  histone-lysine N-methyltransferase SETD5 isoform X10

      UniProtKB/TrEMBL
      B3KRD6

    44. XM_054347132.1 → XP_054203107.1  histone-lysine N-methyltransferase SETD5 isoform X12

      UniProtKB/TrEMBL
      B3KRD6, E7EWN3

    45. XM_054347142.1 → XP_054203117.1  histone-lysine N-methyltransferase SETD5 isoform X18

      UniProtKB/Swiss-Prot
      Q6AI17, Q8WUB6, Q9C0A6, Q9H3X4, Q9H6V7, Q9H7S3, Q9NVI9
      UniProtKB/TrEMBL
      B3KRD6

    46. XM_054347144.1 → XP_054203119.1  histone-lysine N-methyltransferase SETD5 isoform X19

      UniProtKB/TrEMBL
      B3KRD6

    47. XM_054347111.1 → XP_054203086.1  histone-lysine N-methyltransferase SETD5 isoform X1

      UniProtKB/TrEMBL
      B3KRD6

    48. XM_054347145.1 → XP_054203120.1  histone-lysine N-methyltransferase SETD5 isoform X20

      UniProtKB/TrEMBL
      B3KRD6

    49. XM_054347146.1 → XP_054203121.1  histone-lysine N-methyltransferase SETD5 isoform X21

      UniProtKB/TrEMBL
      B3KRD6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_018187.2: Suppressed sequence

      Description
      NM_018187.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C0A6.2 GenPept UniProtKB/Swiss-Prot:Q9C0A6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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