PACRGL parkin coregulated like [Homo sapiens (human)] - Gene

Summary

Official Symbol: PACRGLprovided by HGNC
Official Full Name: parkin coregulated likeprovided by HGNC
Primary source: HGNC:HGNC:28442
See related: Ensembl:ENSG00000163138 AllianceGenome:HGNC:28442
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C4orf28
Expression: Broad expression in brain (RPKM 3.7), testis (RPKM 3.2) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4p15.31

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (20696282..20767373)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (20677960..20749010)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (20697905..20754523)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p- TGF-beta1 axis.
Title: Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p- TGF-β1 axis.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH92764 (e-PCR)
- UniSTS:87094

RH93232 (e-PCR)
- UniSTS:93010

D4S2590E (e-PCR)
- UniSTS:44025

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: PACRG-like protein

Names: PARK2 co-regulated like; PARK2 coregulated like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130727.3 → NP_001124199.1 PACRG-like protein isoform 2

See identical proteins and their annotated locations for NP_001124199.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks three consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC104065, BU674750, BX104331

Consensus CDS

CCDS47034.1

UniProtKB/TrEMBL

D6RF67

Related

ENSP00000415832.2, ENST00000444671.6

Conserved Domains (1) summary

pfam10274
Location:64 → 120

ParcG; Parkin co-regulated protein
NM_001258345.3 → NP_001245274.1 PACRG-like protein isoform 3

See identical proteins and their annotated locations for NP_001245274.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is longer than isoform 1.

Source sequence(s)

AC104065, AK291544, BM763154, BU674750, BX104331, CF121351, DC339941

Consensus CDS

CCDS58895.1

UniProtKB/Swiss-Prot

B2RDB9, B4DFF8, B4DMN7, Q8N7B6, Q8TBA8

UniProtKB/TrEMBL

A8K679

Related

ENSP00000423881.1, ENST00000503585.6

Conserved Domains (1) summary

pfam10274
Location:78 → 245

ParcG; Parkin co-regulated protein
NM_001258346.3 → NP_001245275.1 PACRG-like protein isoform 4

See identical proteins and their annotated locations for NP_001245275.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) has multiple differences compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AC104065, AK294077, BU674750, BX104331, CF121351

Consensus CDS

CCDS58896.1

UniProtKB/Swiss-Prot

Q8N7B6

Related

ENSP00000425461.1, ENST00000502374.5

Conserved Domains (1) summary

pfam10274
Location:70 → 148

ParcG; Parkin co-regulated protein
NM_001317849.3 → NP_001304778.1 PACRG-like protein isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in its 5' UTR and lacks two consecutive exons in the central coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1. Variants 6-10 all encode the same isoform (5).

Source sequence(s)

AC104065, AK291544, BU674750, BX104331, BX344401, CF121351, DC339941

Consensus CDS

CCDS82912.1

UniProtKB/TrEMBL

D6RAM4, D6RGK2

Related

ENSP00000426286.1, ENST00000513459.5

Conserved Domains (1) summary

pfam10274
Location:70 → 165

ParcG; Parkin co-regulated protein
NM_001330745.2 → NP_001317674.1 PACRG-like protein isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks two consecutive exons in the central coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.

Source sequence(s)

AC104065, BC023002, BU674750, BX104331, CF121351, DC339941

Consensus CDS

CCDS82912.1

UniProtKB/TrEMBL

D6RAM4, D6RGK2
NM_001330746.2 → NP_001317675.1 PACRG-like protein isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (8) differs in its 5' UTR and lacks two consecutive exons in the central coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1. Variants 6-10 all encode the same isoform (5).

Source sequence(s)

AC104065, AL541740, BC023002, BU674750, BX104331, CF121351, DC339941

Consensus CDS

CCDS82912.1

UniProtKB/TrEMBL

D6RAM4, D6RGK2
NM_001330747.2 → NP_001317676.1 PACRG-like protein isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (9) differs in its 5' UTR and lacks two consecutive exons in the central coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1. Variants 6-10 all encode the same isoform (5).

Source sequence(s)

AC104065, AK307092, BC023002, BU674750, BX104331, CF121351, DC339941

Consensus CDS

CCDS82912.1

UniProtKB/TrEMBL

D6RAM4, D6RGK2
NM_001330748.2 → NP_001317677.1 PACRG-like protein isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (10) differs in its 5' UTR and lacks two consecutive exons in the central coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1. Variants 6-10 all encode the same isoform (5).

Source sequence(s)

AC104065, AK307786, BC023002, BU674750, BX104331, CF121351

Consensus CDS

CCDS82912.1

UniProtKB/TrEMBL

D6RAM4, D6RGK2

Related

ENSP00000422394.1, ENST00000513861.5
NM_145048.5 → NP_659485.1 PACRG-like protein isoform 1

See identical proteins and their annotated locations for NP_659485.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AC104065, BC023002, BU674750, BX104331, CF121351, DC339941

Consensus CDS

CCDS3427.1

UniProtKB/TrEMBL

D6RC13

Related

ENSP00000354171.4, ENST00000360916.9

Conserved Domains (1) summary

pfam10274
Location:78 → 218

ParcG; Parkin co-regulated protein

RNA

NR_047661.3 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC104065, AK307355, BG741791, BU674750, BX104331, CF121351, DC339941
NR_133933.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (11) uses an alternate 5' and 3' exon structure, and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay.

Source sequence(s)

AK098692, AK291544, AW050492, BM763154