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    EVC EvC ciliary complex subunit 1 [ Homo sapiens (human) ]

    Gene ID: 2121, updated on 10-Dec-2024

    Summary

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    Official Symbol
    EVCprovided by HGNC
    Official Full Name
    EvC ciliary complex subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:3497
    See related
    Ensembl:ENSG00000072840 MIM:604831; AllianceGenome:HGNC:3497
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EVC1; EVCL; DWF-1
    Summary
    This gene encodes a protein containing a leucine zipper and a transmembrane domain. This gene has been implicated in both Ellis-van Creveld syndrome (EvC) and Weyers acrodental dysostosis. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in ovary (RPKM 10.7), kidney (RPKM 10.3) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EVC in Genome Data Viewer
    Location:
    4p16.2
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (5711201..5829057)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (5682855..5800650)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (5712928..5816032)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:5526681-5527880 Neighboring gene uncharacterized LOC124900166 Neighboring gene long intergenic non-protein coding RNA 1587 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:5593995-5594527 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:5595317-5595818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:5595819-5596318 Neighboring gene EvC ciliary complex subunit 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:5610365-5610542 Neighboring gene NANOG hESC enhancer GRCh37_chr4:5613379-5613880 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:5641443-5642642 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:5666069-5667268 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21241 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:5710226-5710845 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21243 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15224 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:5754671-5755626 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:5760129-5761328 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:5774235-5774978 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:5774979-5775720 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21246 Neighboring gene NANOG hESC enhancer GRCh37_chr4:5876470-5876991 Neighboring gene collapsin response mediator protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:5888332-5888859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:5888860-5889386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:5891930-5892674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:5892675-5893418 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:5914348-5914973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:5923869-5924368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:5926351-5926851 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:5932940-5933440 Neighboring gene chromosome 4 open reading frame 50 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:5947182-5947682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:5957977-5958528 Neighboring gene microRNA 378d-1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15225 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:5972715-5973525 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:5975147-5975708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:5975709-5976269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:5995614-5996166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:5996167-5996718 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:6050907-6052106 Neighboring gene uncharacterized LOC128125818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6071730-6072660 Neighboring gene janus kinase and microtubule interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The gene for the Ellis-van Creveld syndrome is located on chromosome 4p16. Polymeropoulos MH, et al. Genomics, 1996 Jul 1. PMID 8661097
    2. Mutations in the EVC1 gene are not a common finding in the Ellis-van Creveld and short rib-polydactyly type III syndromes. Takamine Y, et al. Am J Med Genet A, 2004 Sep 15. PMID 15368503
    3. Extending the spectrum of Ellis van Creveld syndrome: a large family with a mild mutation in the EVC gene. Ulucan H, et al. BMC Med Genet, 2008 Oct 23. PMID 18947413, Free PMC Article
    4. A novel missense mutation in the EVC gene underlies Ellis-van Creveld syndrome in a Pakistani family. Umm-E-Kalsoom, et al. Pediatr Int, 2010 Apr. PMID 19744229
    5. Epigenetic deregulation of Ellis Van Creveld confers robust Hedgehog signaling in adult T-cell leukemia. Takahashi R, et al. Cancer Sci, 2014 Sep. PMID 24996003, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An intrafamilial phenotypic variability in Ellis-Van Creveld syndrome due to a novel 27 bps deletion mutation.
      Title: An intrafamilial phenotypic variability in Ellis-Van Creveld syndrome due to a novel 27 bps deletion mutation.
    2. the whole exome sequencing (WES) in this family revealed two homozygous variants in EVC2 (c.30dupC; p.Thr11Hisfs*45) and TMC1 (c.1696-1G>A) genes. In family B, WES revealed novel compound heterozygous variants (p.Ser307Pro, c.2894+3A>G) in the EVC gene.
      Title: Ellis-van Creveld syndrome and profound deafness resulted by sequence variants in the EVC/EVC2 and TMC1 genes.
    3. The molecular mechanism underlying the development of ventricular septal defect induced by the EVC c.343C>G mutation may be due to a reduction in the anti-apoptotic and proliferative abilities of cardiomyocytes via downregulation of Hh pathway activity.
      Title: Molecular mechanisms of Ellis‑van Creveld gene variations in ventricular septal defect.
    4. Here, we report on two Mexican families with patients diagnosed with Ellis-van Creveld syndrome. In all cases, molecular analysis by Sanger sequencing identified the same homozygous mutation in exon 12 of EVC, c.1678G>T, which leads to a premature stop codon.
      Title: Phenotypic Variation in Patients with Homozygous c.1678G>T Mutation in EVC Gene: Report of Two Mexican Families with Ellis-van Creveld Syndrome.
    5. we detected two novel nonsense mutations and a partial deletion of EVC/EVC2 in two Vietnamese families with EvC. Moreover, we found in one family a missense mutation of EFCAB7, a possible modifier gene in EvC and its related disorders.
      Title: Truncation and microdeletion of EVC/EVC2 with missense mutation of EFCAB7 in Ellis-van Creveld syndrome.
    6. sequence analysis identified a novel nonsense mutation (p.Trp234*) in exon 8 of the EVC2 gene and 15 bp duplication in exon 14 of the EVC gene in the two families.
      Title: Novel homozygous mutations in the EVC and EVC2 genes in two consanguineous families segregating autosomal recessive Ellis-van Creveld syndrome.
    7. Sequencing of both EVC and EVC2 identified two novel heterozygous splice site mutations c.384+5G>C in intron 3 and c.1465-1G>A in intron 10 in EVC, which were inherited from mother and father, respectively.
      Title: Novel mutations in EVC cause aberrant splicing in Ellis-van Creveld syndrome.
    8. The epigenetically deregulated EVC appears to play an important role for hedgehog activation.
      Title: Epigenetic deregulation of Ellis Van Creveld confers robust Hedgehog signaling in adult T-cell leukemia.
    9. Molecular analysis of the EVC and EVC2 genes is helpful in genetic counseling in cases with prenatally detected postaxial polydactyly, thoracic narrowness, short limbs and endocardial cushion defects.
      Title: Ellis-van Creveld syndrome: prenatal diagnosis, molecular analysis and genetic counseling.
    10. We herein report on the first family from Pakistan with a large number of individuals affected by EVC. DNA sequence analysis led to the identification of the fifth missense mutation in the EVC gene
      Title: A novel missense mutation in the EVC gene underlies Ellis-van Creveld syndrome in a Pakistani family.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Curry-Hall syndrome
    MedGen: C0457013 OMIM: 193530 GeneReviews: Not available
    		Compare labs
    Ellis-van Creveld syndrome
    MedGen: C0013903 OMIM: 225500 GeneReviews: Ellis-van Creveld Syndrome
    		Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105107

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cartilage development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endochondral bone growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in muscle organ development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in skeletal system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in ciliary membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of plasma membrane protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    evC complex member EVC
    Names
    Ellis van Creveld protein
    Ellis van Creveld syndrome
    ellis-van Creveld syndrome protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008843.2 RefSeqGene

      Range
      5002..108106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306090.2 → NP_001293019.1  evC complex member EVC isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC105915, AF216185, AF239742
      UniProtKB/TrEMBL
      Q4W5F2

    2. NM_001306092.2 → NP_001293021.1  evC complex member EVC isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks exons in the 3' coding region and uses an alternate 3' terminal exon compared to variant 1. It encodes isoform 3, which is shorter than and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC105915, AF216185, BC085608
      Consensus CDS
      CCDS77896.1
      UniProtKB/TrEMBL
      E9PCN4, Q5U3C2
      Related
      ENSP00000426774.1, ENST00000509451.1

    3. NM_153717.3 → NP_714928.1  evC complex member EVC isoform 1

      See identical proteins and their annotated locations for NP_714928.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC105915, AF216185
      Consensus CDS
      CCDS3383.1
      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2
      Related
      ENSP00000264956.6, ENST00000264956.11

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      5711201..5829057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449774.1 → XP_047305730.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    2. XM_047449769.1 → XP_047305725.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    3. XM_047449778.1 → XP_047305734.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    4. XM_047449773.1 → XP_047305729.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    5. XM_047449786.1 → XP_047305742.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    6. XM_047449781.1 → XP_047305737.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    7. XM_047449777.1 → XP_047305733.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    8. XM_047449776.1 → XP_047305732.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    9. XM_047449780.1 → XP_047305736.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    10. XM_047449779.1 → XP_047305735.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    11. XM_047449785.1 → XP_047305741.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    12. XM_047449795.1 → XP_047305751.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    13. XM_047449775.1 → XP_047305731.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    14. XM_047449771.1 → XP_047305727.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    15. XM_047449784.1 → XP_047305740.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    16. XM_047449772.1 → XP_047305728.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    17. XM_047449787.1 → XP_047305743.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    18. XM_047449792.1 → XP_047305748.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    19. XM_047449789.1 → XP_047305745.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    20. XM_047449790.1 → XP_047305746.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    21. XM_047449798.1 → XP_047305754.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    22. XM_047449796.1 → XP_047305752.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    23. XM_047449770.1 → XP_047305726.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    24. XM_047449783.1 → XP_047305739.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    25. XM_047449782.1 → XP_047305738.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    26. XM_047449788.1 → XP_047305744.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    27. XM_047449791.1 → XP_047305747.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    28. XM_047449797.1 → XP_047305753.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    29. XM_047449793.1 → XP_047305749.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    30. XM_047449794.1 → XP_047305750.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    31. XM_047449799.1 → XP_047305755.1  evC complex member EVC isoform X1

      UniProtKB/Swiss-Prot
      P57679
      UniProtKB/TrEMBL
      Q4W5F2

    32. XM_047449800.1 → XP_047305756.1  evC complex member EVC isoform X2

      UniProtKB/TrEMBL
      Q4W5F2

    33. XM_047449801.1 → XP_047305757.1  evC complex member EVC isoform X2

      UniProtKB/TrEMBL
      Q4W5F2

    34. XM_047449807.1 → XP_047305763.1  evC complex member EVC isoform X2

      UniProtKB/TrEMBL
      Q4W5F2

    35. XM_047449804.1 → XP_047305760.1  evC complex member EVC isoform X2

      UniProtKB/TrEMBL
      Q4W5F2

    36. XM_047449803.1 → XP_047305759.1  evC complex member EVC isoform X2

      UniProtKB/TrEMBL
      Q4W5F2

    37. XM_047449802.1 → XP_047305758.1  evC complex member EVC isoform X2

      UniProtKB/TrEMBL
      Q4W5F2

    38. XM_047449805.1 → XP_047305761.1  evC complex member EVC isoform X2

      UniProtKB/TrEMBL
      Q4W5F2

    39. XM_047449806.1 → XP_047305762.1  evC complex member EVC isoform X2

      UniProtKB/TrEMBL
      Q4W5F2

    40. XM_047449808.1 → XP_047305764.1  evC complex member EVC isoform X3

      UniProtKB/TrEMBL
      Q4W5F2

    41. XM_047449809.1 → XP_047305765.1  evC complex member EVC isoform X4

    42. XM_011513419.3 → XP_011511721.1  evC complex member EVC isoform X6

      UniProtKB/TrEMBL
      Q5U3C2

    43. XM_017007883.3 → XP_016863372.1  evC complex member EVC isoform X7

      UniProtKB/TrEMBL
      Q5U3C2

    44. XM_047449810.1 → XP_047305766.1  evC complex member EVC isoform X5

      UniProtKB/TrEMBL
      Q4W5F2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      5682855..5800650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349202.1 → XP_054205177.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    2. XM_054349197.1 → XP_054205172.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    3. XM_054349206.1 → XP_054205181.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    4. XM_054349201.1 → XP_054205176.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    5. XM_054349214.1 → XP_054205189.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    6. XM_054349209.1 → XP_054205184.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    7. XM_054349205.1 → XP_054205180.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    8. XM_054349204.1 → XP_054205179.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    9. XM_054349208.1 → XP_054205183.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    10. XM_054349207.1 → XP_054205182.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    11. XM_054349213.1 → XP_054205188.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    12. XM_054349223.1 → XP_054205198.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    13. XM_054349203.1 → XP_054205178.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    14. XM_054349199.1 → XP_054205174.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    15. XM_054349212.1 → XP_054205187.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    16. XM_054349200.1 → XP_054205175.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    17. XM_054349215.1 → XP_054205190.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    18. XM_054349220.1 → XP_054205195.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    19. XM_054349217.1 → XP_054205192.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    20. XM_054349218.1 → XP_054205193.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    21. XM_054349226.1 → XP_054205201.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    22. XM_054349224.1 → XP_054205199.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    23. XM_054349198.1 → XP_054205173.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    24. XM_054349211.1 → XP_054205186.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    25. XM_054349210.1 → XP_054205185.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    26. XM_054349216.1 → XP_054205191.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    27. XM_054349219.1 → XP_054205194.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    28. XM_054349225.1 → XP_054205200.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    29. XM_054349221.1 → XP_054205196.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    30. XM_054349222.1 → XP_054205197.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    31. XM_054349227.1 → XP_054205202.1  evC complex member EVC isoform X1

      UniProtKB/TrEMBL
      Q4W5F2

    32. XM_054349228.1 → XP_054205203.1  evC complex member EVC isoform X2

      UniProtKB/TrEMBL
      Q4W5F2

    33. XM_054349229.1 → XP_054205204.1  evC complex member EVC isoform X2

      UniProtKB/TrEMBL
      Q4W5F2

    34. XM_054349235.1 → XP_054205210.1  evC complex member EVC isoform X2

      UniProtKB/TrEMBL
      Q4W5F2

    35. XM_054349232.1 → XP_054205207.1  evC complex member EVC isoform X2

      UniProtKB/TrEMBL
      Q4W5F2

    36. XM_054349231.1 → XP_054205206.1  evC complex member EVC isoform X2

      UniProtKB/TrEMBL
      Q4W5F2

    37. XM_054349230.1 → XP_054205205.1  evC complex member EVC isoform X2

      UniProtKB/TrEMBL
      Q4W5F2

    38. XM_054349233.1 → XP_054205208.1  evC complex member EVC isoform X2

      UniProtKB/TrEMBL
      Q4W5F2

    39. XM_054349234.1 → XP_054205209.1  evC complex member EVC isoform X2

      UniProtKB/TrEMBL
      Q4W5F2

    40. XM_054349236.1 → XP_054205211.1  evC complex member EVC isoform X3

      UniProtKB/TrEMBL
      Q4W5F2

    41. XM_054349237.1 → XP_054205212.1  evC complex member EVC isoform X4

    42. XM_054349239.1 → XP_054205214.1  evC complex member EVC isoform X6

      UniProtKB/TrEMBL
      Q5U3C2

    43. XM_054349240.1 → XP_054205215.1  evC complex member EVC isoform X7

      UniProtKB/TrEMBL
      Q5U3C2

    44. XM_054349238.1 → XP_054205213.1  evC complex member EVC isoform X5

      UniProtKB/TrEMBL
      Q4W5F2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_014556.2: Suppressed sequence

      Description
      NM_014556.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P57679.1 GenPept UniProtKB/Swiss-Prot:P57679

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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