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    PALLD palladin, cytoskeletal associated protein [ Homo sapiens (human) ]

    Gene ID: 23022, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PALLDprovided by HGNC
    Official Full Name
    palladin, cytoskeletal associated proteinprovided by HGNC
    Primary source
    HGNC:HGNC:17068
    See related
    Ensembl:ENSG00000129116 MIM:608092; AllianceGenome:HGNC:17068
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MYN; PNCA1; CGI151; SIH002; CGI-151
    Summary
    This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
    Expression
    Ubiquitous expression in endometrium (RPKM 88.4), prostate (RPKM 49.6) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PALLD in Genome Data Viewer
    Location:
    4q32.3
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (168497052..168928441)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (171856045..172287862)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (169418203..169849592)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene DExD/H-box helicase 60 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22124 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76106 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76110 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76113 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76114 Neighboring gene DExD/H-box 60 like Neighboring gene small nucleolar RNA SNORA51 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22125 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:169408038-169409237 Neighboring gene uncharacterized LOC107986198 Neighboring gene uncharacterized LOC124900807 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76181 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76192 Neighboring gene basic transcription factor 3 like 4 pseudogene 4 Neighboring gene uncharacterized LOC124900808 Neighboring gene PALLD antisense RNA 1 Neighboring gene RNA, U6 small nuclear 1336, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:169655047-169655546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:169654545-169655046 Neighboring gene NANOG hESC enhancer GRCh37_chr4:169656832-169657333 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:169679045-169679545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22126 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:169724789-169725442 Neighboring gene ribosomal protein L9 pseudogene 16 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:169737021-169737655 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:169737656-169738291 Neighboring gene uncharacterized LOC124900809 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:169752834-169753694 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:169762142-169762656 Neighboring gene uncharacterized LOC102723331 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:169798790-169799374 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22127 Neighboring gene RNA, U6 small nuclear 853, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:169851979-169852480 Neighboring gene uncharacterized LOC107986200 Neighboring gene carbonyl reductase 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:169915462-169916268 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:169916269-169917074 Neighboring gene RNY4 pseudogene 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Palladin is a marker of liver metastasis in primary pancreatic endocrine carcinomas. Henderson-Jackson EB, et al. Anticancer Res, 2011 Sep. PMID 21868544
    2. Palladin contributes to invasive motility in human breast cancer cells. Goicoechea SM, et al. Oncogene, 2009 Jan 29. PMID 18978809, Free PMC Article
    3. PALLD mutation in a European family conveys a stromal predisposition for familial pancreatic cancer. Liotta L, et al. JCI Insight, 2021 Mar 25. PMID 33764904, Free PMC Article
    4. Human adipose-derived adult stem cells upregulate palladin during osteogenesis and in response to cyclic tensile strain. Wall ME, et al. Am J Physiol Cell Physiol, 2007 Nov. PMID 17687002
    5. Absence of deleterious palladin mutations in patients with familial pancreatic cancer. Klein AP, et al. Cancer Epidemiol Biomarkers Prev, 2009 Apr. PMID 19336541, Free PMC Article

    See all (143) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [High expression of Circ-PALLD in heart failure is transcriptionally regulated by the transcription factor GATA4].
      Title: [High expression of Circ-PALLD in heart failure is transcriptionally regulated by the transcription factor GATA4].
    2. Palladin promotes cancer stem cell-like properties in lung cancer by activating Wnt/Beta-Catenin signaling.
      Title: Palladin promotes cancer stem cell-like properties in lung cancer by activating Wnt/Β-Catenin signaling.
    3. Different Extracellular beta-Amyloid (1-42) Aggregates Differentially Impair Neural Cell Adhesion and Neurite Outgrowth through Differential Induction of Scaffold Palladin.
      Title: Different Extracellular β-Amyloid (1-42) Aggregates Differentially Impair Neural Cell Adhesion and Neurite Outgrowth through Differential Induction of Scaffold Palladin.
    4. PALLD mutation in a European family conveys a stromal predisposition for familial pancreatic cancer.
      Title: PALLD mutation in a European family conveys a stromal predisposition for familial pancreatic cancer.
    5. Palladin isoforms 3 and 4 regulate cancer-associated fibroblast pro-tumor functions in pancreatic ductal adenocarcinoma.
      Title: Palladin isoforms 3 and 4 regulate cancer-associated fibroblast pro-tumor functions in pancreatic ductal adenocarcinoma.
    6. Expression of palladin is associated with disease progression in metastatic high-grade serous carcinoma.
      Title: Expression of palladin is associated with disease progression in metastatic high-grade serous carcinoma.
    7. Taken together, this study demonstrates that palladin plays an important role in themorphology and dynamic behavior of podocytes in vivo and in vitro.
      Title: The Role of Palladin in Podocytes.
    8. findings revealed that Palladin regulates spindle orientation and mitotic progression mainly through the AKT1-GSK3beta pathway.
      Title: Palladin is a novel microtubule-associated protein responsible for spindle orientation.
    9. Collectively, our results demonstrate that palladin can functionally replace the Arp2/3 complex during bacterial actin-based cellular entry and intracellular motility of Listeria monocytogenes.
      Title: Palladin Compensates for the Arp2/3 Complex and Supports Actin Structures during Listeria Infections.
    10. Twist1 appears to require both palladin and collagen alpha1(VI) as downstream effectors for its prometastatic effects, which could be future therapeutic targets in cancer metastasis.
      Title: Twist1-induced activation of human fibroblasts promotes matrix stiffness by upregulating palladin and collagen α1(VI).
    Submit: New GeneRIF Correction See all GeneRIFs (43)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Pancreatic cancer, susceptibility to, 1
    MedGen: C1847351 OMIM: 606856 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.
    EBI GWAS Catalog
    Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22190, FLJ38193, FLJ39139, FLJ61376, KIAA0992

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables muscle alpha-actinin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in dendrite self-avoidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinocyte development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in excitatory synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in focal adhesion HDA PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in podosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    palladin
    Names
    myoneurin
    sarcoma antigen NY-SAR-77

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013376.1 RefSeqGene

      Range
      4987..436376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001166108.2 → NP_001159580.1  palladin isoform 1

      See identical proteins and their annotated locations for NP_001159580.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC079926, AF077041, AF464873, AI418424, AK025843, BC144666
      Consensus CDS
      CCDS54818.1
      UniProtKB/Swiss-Prot
      Q8WX93
      Related
      ENSP00000425556.1, ENST00000505667.6
      Conserved Domains (3) summary
      cd00096
      Location:458 → 535
      Ig; Immunoglobulin domain
      cd05893
      Location:1044 → 1118
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:271 → 361
      I-set; Immunoglobulin I-set domain

    2. NM_001166109.2 → NP_001159581.1  palladin isoform 3

      See identical proteins and their annotated locations for NP_001159581.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream translational start codon, lacks an alternate in-frame exon in the central coding region, and lacks an exon in the 3' coding region that results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC079858, AC084353, AF077041, AI418424, AK025843, AK095512, DA048169
      Consensus CDS
      CCDS54819.1
      UniProtKB/Swiss-Prot
      Q8WX93
      Related
      ENSP00000426947.1, ENST00000512127.5
      Conserved Domains (3) summary
      cd00096
      Location:76 → 153
      Ig; Immunoglobulin domain
      cd05893
      Location:645 → 719
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:529 → 619
      I-set; Immunoglobulin I-set domain

    3. NM_001166110.2 → NP_001159582.1  palladin isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks several exons in the 5' coding region, uses an alternate translational start codon, lacks an alternate in-frame exon in the central coding region, and lacks an exon in the 3' coding region that results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AB023209, AC080188, AF077041, AI418424, DB257974
      Consensus CDS
      CCDS54820.1
      UniProtKB/Swiss-Prot
      Q8WX93
      Related
      ENSP00000424016.1, ENST00000507735.6
      Conserved Domains (4) summary
      cd00096
      Location:424 → 427
      Ig; Ig strand A [structural motif]
      cd05892
      Location:523 → 614
      IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
      cd05893
      Location:290 → 381
      IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:424 → 514
      Ig; Immunoglobulin domain

    4. NM_001367567.1 → NP_001354496.1  palladin isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC080188, AC115538
      Conserved Domains (3) summary
      cd05892
      Location:303 → 394
      IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
      cd05893
      Location:70 → 161
      IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
      cd20990
      Location:204 → 294
      IgI_2_Palladin_C; Second C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains

    5. NM_001367568.1 → NP_001354497.1  palladin isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC080188, AC115538
      Consensus CDS
      CCDS93667.1
      UniProtKB/TrEMBL
      A0A994J7A4
      Related
      ENSP00000516055.1, ENST00000704822.1

    6. NM_001367569.1 → NP_001354498.1  palladin isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC080188, AC115538

    7. NM_001367570.1 → NP_001354499.1  palladin isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC080188, AC115538
      Conserved Domains (3) summary
      cd05892
      Location:320 → 411
      IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
      cd05893
      Location:87 → 178
      IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
      cd20990
      Location:221 → 311
      IgI_2_Palladin_C; Second C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains

    8. NM_016081.4 → NP_057165.3  palladin isoform 2

      See identical proteins and their annotated locations for NP_057165.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC079926, AC115538, AF464873, AW248292
      Consensus CDS
      CCDS34098.1
      UniProtKB/TrEMBL
      B2RTX2
      Related
      ENSP00000261509.6, ENST00000261509.10
      Conserved Domains (3) summary
      cd05893
      Location:1027 → 1101
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:271 → 361
      I-set; Immunoglobulin I-set domain
      cl25751
      Location:77 → 237
      DUF4045; Domain of unknown function (DUF4045)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      168497052..168928441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531768.3 → XP_011530070.1  palladin isoform X1

      UniProtKB/Swiss-Prot
      B3KTG2, B5MD56, B7ZMM5, Q7L3E0, Q7Z3W0, Q86WE8, Q8N1M2, Q8WX93, Q9UGA0, Q9UQF5, Q9Y2J6, Q9Y3E9
      Conserved Domains (3) summary
      cd00096
      Location:526 → 603
      Ig; Immunoglobulin domain
      cd05893
      Location:1336 → 1410
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:339 → 429
      I-set; Immunoglobulin I-set domain

    2. XM_011531769.3 → XP_011530071.1  palladin isoform X2

      UniProtKB/Swiss-Prot
      B3KTG2, B5MD56, B7ZMM5, Q7L3E0, Q7Z3W0, Q86WE8, Q8N1M2, Q8WX93, Q9UGA0, Q9UQF5, Q9Y2J6, Q9Y3E9
      Conserved Domains (3) summary
      cd00096
      Location:526 → 603
      Ig; Immunoglobulin domain
      cd05893
      Location:1319 → 1393
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:339 → 429
      I-set; Immunoglobulin I-set domain

    3. XM_011531771.3 → XP_011530073.1  palladin isoform X5

      UniProtKB/Swiss-Prot
      B3KTG2, B5MD56, B7ZMM5, Q7L3E0, Q7Z3W0, Q86WE8, Q8N1M2, Q8WX93, Q9UGA0, Q9UQF5, Q9Y2J6, Q9Y3E9
      Conserved Domains (4) summary
      cd00096
      Location:526 → 603
      Ig; Immunoglobulin domain
      cd05893
      Location:1245 → 1319
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:339 → 429
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:1025 → 1086
      Ig; Immunoglobulin domain

    4. XM_011531772.3 → XP_011530074.1  palladin isoform X6

      UniProtKB/Swiss-Prot
      B3KTG2, B5MD56, B7ZMM5, Q7L3E0, Q7Z3W0, Q86WE8, Q8N1M2, Q8WX93, Q9UGA0, Q9UQF5, Q9Y2J6, Q9Y3E9
      Conserved Domains (3) summary
      cd00096
      Location:526 → 603
      Ig; Immunoglobulin domain
      cd05893
      Location:1212 → 1286
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:339 → 429
      I-set; Immunoglobulin I-set domain

    5. XM_011531773.2 → XP_011530075.1  palladin isoform X7

      UniProtKB/Swiss-Prot
      B3KTG2, B5MD56, B7ZMM5, Q7L3E0, Q7Z3W0, Q86WE8, Q8N1M2, Q8WX93, Q9UGA0, Q9UQF5, Q9Y2J6, Q9Y3E9
      Conserved Domains (3) summary
      cd00096
      Location:526 → 603
      Ig; Immunoglobulin domain
      cd05893
      Location:1112 → 1186
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:339 → 429
      I-set; Immunoglobulin I-set domain

    6. XM_011531774.2 → XP_011530076.1  palladin isoform X8

      UniProtKB/Swiss-Prot
      B3KTG2, B5MD56, B7ZMM5, Q7L3E0, Q7Z3W0, Q86WE8, Q8N1M2, Q8WX93, Q9UGA0, Q9UQF5, Q9Y2J6, Q9Y3E9
      Conserved Domains (3) summary
      cd00096
      Location:526 → 603
      Ig; Immunoglobulin domain
      cd05893
      Location:1095 → 1169
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:339 → 429
      I-set; Immunoglobulin I-set domain

    7. XM_047449863.1 → XP_047305819.1  palladin isoform X9

    8. XM_047449864.1 → XP_047305820.1  palladin isoform X10

    9. XM_047449861.1 → XP_047305817.1  palladin isoform X3

      UniProtKB/Swiss-Prot
      B3KTG2, B5MD56, B7ZMM5, Q7L3E0, Q7Z3W0, Q86WE8, Q8N1M2, Q8WX93, Q9UGA0, Q9UQF5, Q9Y2J6, Q9Y3E9

    10. XM_047449862.1 → XP_047305818.1  palladin isoform X4

      UniProtKB/Swiss-Prot
      B3KTG2, B5MD56, B7ZMM5, Q7L3E0, Q7Z3W0, Q86WE8, Q8N1M2, Q8WX93, Q9UGA0, Q9UQF5, Q9Y2J6, Q9Y3E9

    11. XM_024453939.2 → XP_024309707.1  palladin isoform X10

      Conserved Domains (2) summary
      cd05893
      Location:886 → 960
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:770 → 860
      I-set; Immunoglobulin I-set domain

    12. XM_011531775.2 → XP_011530077.1  palladin isoform X10

      See identical proteins and their annotated locations for XP_011530077.1

      Conserved Domains (2) summary
      cd05893
      Location:886 → 960
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:770 → 860
      I-set; Immunoglobulin I-set domain

    13. XM_047449865.1 → XP_047305821.1  palladin isoform X11

    14. XM_047449866.1 → XP_047305822.1  palladin isoform X12

    15. XM_024453940.2 → XP_024309708.1  palladin isoform X13

      Conserved Domains (4) summary
      cd00096
      Location:441 → 444
      Ig; Ig strand A [structural motif]
      cd05892
      Location:540 → 631
      IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
      cd05893
      Location:307 → 398
      IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:441 → 531
      Ig; Immunoglobulin domain

    16. XM_047449867.1 → XP_047305823.1  palladin isoform X14

    17. XM_047449868.1 → XP_047305824.1  palladin isoform X15

    18. XM_047449869.1 → XP_047305825.1  palladin isoform X16

    19. XM_047449870.1 → XP_047305826.1  palladin isoform X17

      Conserved Domains (3) summary
      cd05892
      Location:303 → 394
      IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
      cd05893
      Location:70 → 161
      IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
      cd20990
      Location:204 → 294
      IgI_2_Palladin_C; Second C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      171856045..172287862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349339.1 → XP_054205314.1  palladin isoform X1

      UniProtKB/Swiss-Prot
      B3KTG2, B5MD56, B7ZMM5, Q7L3E0, Q7Z3W0, Q86WE8, Q8N1M2, Q8WX93, Q9UGA0, Q9UQF5, Q9Y2J6, Q9Y3E9

    2. XM_054349340.1 → XP_054205315.1  palladin isoform X2

      UniProtKB/Swiss-Prot
      B3KTG2, B5MD56, B7ZMM5, Q7L3E0, Q7Z3W0, Q86WE8, Q8N1M2, Q8WX93, Q9UGA0, Q9UQF5, Q9Y2J6, Q9Y3E9

    3. XM_054349343.1 → XP_054205318.1  palladin isoform X5

      UniProtKB/Swiss-Prot
      B3KTG2, B5MD56, B7ZMM5, Q7L3E0, Q7Z3W0, Q86WE8, Q8N1M2, Q8WX93, Q9UGA0, Q9UQF5, Q9Y2J6, Q9Y3E9

    4. XM_054349344.1 → XP_054205319.1  palladin isoform X6

      UniProtKB/Swiss-Prot
      B3KTG2, B5MD56, B7ZMM5, Q7L3E0, Q7Z3W0, Q86WE8, Q8N1M2, Q8WX93, Q9UGA0, Q9UQF5, Q9Y2J6, Q9Y3E9

    5. XM_054349345.1 → XP_054205320.1  palladin isoform X7

      UniProtKB/Swiss-Prot
      B3KTG2, B5MD56, B7ZMM5, Q7L3E0, Q7Z3W0, Q86WE8, Q8N1M2, Q8WX93, Q9UGA0, Q9UQF5, Q9Y2J6, Q9Y3E9

    6. XM_054349346.1 → XP_054205321.1  palladin isoform X8

      UniProtKB/Swiss-Prot
      B3KTG2, B5MD56, B7ZMM5, Q7L3E0, Q7Z3W0, Q86WE8, Q8N1M2, Q8WX93, Q9UGA0, Q9UQF5, Q9Y2J6, Q9Y3E9

    7. XM_054349347.1 → XP_054205322.1  palladin isoform X9

    8. XM_054349350.1 → XP_054205325.1  palladin isoform X10

    9. XM_054349341.1 → XP_054205316.1  palladin isoform X3

      UniProtKB/Swiss-Prot
      B3KTG2, B5MD56, B7ZMM5, Q7L3E0, Q7Z3W0, Q86WE8, Q8N1M2, Q8WX93, Q9UGA0, Q9UQF5, Q9Y2J6, Q9Y3E9

    10. XM_054349342.1 → XP_054205317.1  palladin isoform X4

      UniProtKB/Swiss-Prot
      B3KTG2, B5MD56, B7ZMM5, Q7L3E0, Q7Z3W0, Q86WE8, Q8N1M2, Q8WX93, Q9UGA0, Q9UQF5, Q9Y2J6, Q9Y3E9

    11. XM_054349349.1 → XP_054205324.1  palladin isoform X10

    12. XM_054349348.1 → XP_054205323.1  palladin isoform X10

    13. XM_054349351.1 → XP_054205326.1  palladin isoform X11

    14. XM_054349352.1 → XP_054205327.1  palladin isoform X12

    15. XM_054349353.1 → XP_054205328.1  palladin isoform X13

    16. XM_054349354.1 → XP_054205329.1  palladin isoform X14

    17. XM_054349355.1 → XP_054205330.1  palladin isoform X15

    18. XM_054349356.1 → XP_054205331.1  palladin isoform X16

    19. XM_054349357.1 → XP_054205332.1  palladin isoform X17

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WX93.3 GenPept UniProtKB/Swiss-Prot:Q8WX93

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