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    OPN5 opsin 5 [ Homo sapiens (human) ]

    Gene ID: 221391, updated on 10-Dec-2024

    Summary

    Official Symbol
    OPN5provided by HGNC
    Official Full Name
    opsin 5provided by HGNC
    Primary source
    HGNC:HGNC:19992
    See related
    Ensembl:ENSG00000124818 MIM:609042; AllianceGenome:HGNC:19992
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGR12; GPR136; GRP136; TMEM13
    Summary
    Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
    Expression
    Restricted expression toward testis (RPKM 1.6) See more
    Orthologs
    NEW
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    Genomic context

    See OPN5 in Genome Data Viewer
    Location:
    6p12.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (47782032..47826381)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (47623816..47668165)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (47749768..47794117)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor F4 Neighboring gene RN7SK pseudogene 116 Neighboring gene ribosomal protein L27a pseudogene 7 Neighboring gene RNA, U1 small nuclear 105, pseudogene Neighboring gene uncharacterized LOC107986601 Neighboring gene patched domain containing 4 Neighboring gene Sharpr-MPRA regulatory region 3755 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:48078458-48079657

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 11-cis retinal binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables G protein-coupled photoreceptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled photoreceptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to UV-A IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to light stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to light stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in detection of visible light IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in entrainment of circadian clock by photoperiod ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hyaloid vascular plexus regression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phototransduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phototransduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phototransduction, UV IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in photoreceptor outer segment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    opsin-5
    Names
    G-protein coupled receptor 136
    neuropsin
    transmembrane protein 13

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181744.4NP_859528.1  opsin-5

      See identical proteins and their annotated locations for NP_859528.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the supported protein.
      Source sequence(s)
      AL161622, AL356421
      Consensus CDS
      CCDS4923.1
      UniProtKB/Swiss-Prot
      A0AV33, Q5T5B9, Q5T886, Q6U736, Q7Z603, Q86SL5
      UniProtKB/TrEMBL
      J3KPQ2
      Related
      ENSP00000360255.2, ENST00000371211.7
      Conserved Domains (1) summary
      cd15074
      Location:34316
      7tmA_Opsin5_neuropsin; neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors

    RNA

    1. NR_033806.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two 5' exons but includes a different 5' exon, and also contains an additional internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC042544, BX647224, DB056067
      Related
      ENST00000244799.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      47782032..47826381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010416.2XP_016865905.1  opsin-5 isoform X6

      UniProtKB/TrEMBL
      J3KPQ2
    2. XM_017010410.2XP_016865899.1  opsin-5 isoform X1

    3. XM_017010411.2XP_016865900.1  opsin-5 isoform X2

      UniProtKB/TrEMBL
      J3KPQ2
    4. XM_017010413.2XP_016865902.1  opsin-5 isoform X3

    5. XM_017010412.2XP_016865901.1  opsin-5 isoform X3

    6. XM_047418325.1XP_047274281.1  opsin-5 isoform X5

    7. XM_017010414.2XP_016865903.1  opsin-5 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      47623816..47668165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354561.1XP_054210536.1  opsin-5 isoform X6

      UniProtKB/TrEMBL
      J3KPQ2
    2. XM_054354555.1XP_054210530.1  opsin-5 isoform X1

    3. XM_054354556.1XP_054210531.1  opsin-5 isoform X2

      UniProtKB/TrEMBL
      J3KPQ2
    4. XM_054354558.1XP_054210533.1  opsin-5 isoform X3

    5. XM_054354557.1XP_054210532.1  opsin-5 isoform X3

    6. XM_054354560.1XP_054210535.1  opsin-5 isoform X5

    7. XM_054354559.1XP_054210534.1  opsin-5 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001030051.1: Suppressed sequence

      Description
      NM_001030051.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.