mvk-1 GHMP kinase C-terminal domain-containing protein;MeValonate Kinase;Mevalonate kinase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mvk-1
Official Full Name: GHMP kinase C-terminal domain-containing protein;MeValonate Kinase;Mevalonate kinase
Primary source: WormBase:WBGene00021534
Locus tag: CELE_Y42G9A.4
See related: AllianceGenome:WB:WBGene00021534
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mevalonate kinase activity. Predicted to be involved in cholesterol biosynthetic process and isopentenyl diphosphate biosynthetic process, mevalonate pathway. Located in cytosol. Is expressed in body wall musculature; head; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in hyperimmunoglobulinemia D periodic fever syndrome; lipid metabolism disorder; mevalonic aciduria; and porokeratosis. Orthologous to human MVK (mevalonate kinase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mvk-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 14

Sequence:: Chromosome: III; NC_003281.10 (6124023..6136276, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y42G9A.c (e-PCR)
- UniSTS:323665

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables mevalonate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mevalonate kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphotransferase activity, alcohol group as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	IEA Inferred from Electronic Annotation more info
involved_in isoprenoid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: GHMP kinase C-terminal domain-containing protein;MeValonate Kinase;Mevalonate kinase

NP_001022866.1

Confirmed by transcript evidence

NP_001022867.1

Confirmed by transcript evidence

NP_001367850.1

Confirmed by transcript evidence

NP_001379955.1

Confirmed by transcript evidence

NP_001391146.1

Confirmed by transcript evidence

NP_001391147.1

Confirmed by transcript evidence

NP_001391148.1

Confirmed by transcript evidence

NP_001391150.1

Confirmed by transcript evidence

NP_001391152.1

Confirmed by transcript evidence

NP_001391153.1

Confirmed by transcript evidence

NP_001391155.1

Confirmed by transcript evidence

NP_001391156.1

Confirmed by transcript evidence

NP_001391159.1

Product from WormBase gene class mvk;
Confirmed by transcript evidence

NP_001407509.1

Confirmed by transcript evidence

NP_001408259.1

Confirmed by transcript evidence

NP_001408260.1

Confirmed by transcript evidence

NP_001408261.1

Confirmed by transcript evidence

NP_001408262.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6124023..6136276 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027695.4 → NP_001022866.1 Mevalonate kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022866.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9N4Z7

Conserved Domains (4) summary

PLN02677
Location:46 → 580

PLN02677; mevalonate kinase

pfam00288
Location:265 → 347

GHMP_kinases_N; GHMP kinases N terminal domain

pfam08544
Location:490 → 549

GHMP_kinases_C; GHMP kinases C terminal

pfam15975
Location:378 → 447

Flot; Flotillin
NM_001404151.1 → NP_001391146.1 Mevalonate kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QB65
NM_001027696.7 → NP_001022867.1 Mevalonate kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022867.1

Status: REVIEWED

UniProtKB/TrEMBL

Q65XX9

Conserved Domains (4) summary

PLN02677
Location:146 → 587

PLN02677; mevalonate kinase

pfam00288
Location:272 → 354

GHMP_kinases_N; GHMP kinases N terminal domain

pfam08544
Location:497 → 556

GHMP_kinases_C; GHMP kinases C terminal

pfam15975
Location:385 → 454

Flot; Flotillin
NM_001404150.1 → NP_001391150.1 Mevalonate kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QGK9
NM_001404154.1 → NP_001391152.1 Mevalonate kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QAY9
NM_001421328.1 → NP_001408261.1 Mevalonate kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QD60
NM_001392117.1 → NP_001379955.1 Mevalonate kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q65XX8

Conserved Domains (1) summary

cl40731
Location:16 → 457

PLN02677; mevalonate kinase
NM_001404159.1 → NP_001391159.1 MeValonate Kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QCI1
NM_001379745.1 → NP_001367850.1 Mevalonate kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q65XY0

Conserved Domains (1) summary

cl40731
Location:46 → 487

PLN02677; mevalonate kinase
NM_001421326.1 → NP_001408259.1 Mevalonate kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QCH2
NM_001404147.1 → NP_001391147.1 Mevalonate kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QD84
NM_001421327.1 → NP_001408260.1 Mevalonate kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4Q9F9
NM_001404149.1 → NP_001391148.1 Mevalonate kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QBV1
NM_001404152.1 → NP_001391153.1 Mevalonate kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QFB7
NM_001404155.1 → NP_001391156.1 Mevalonate kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QB79
NM_001421329.1 → NP_001408262.1 Mevalonate kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QD98
NM_001404157.1 → NP_001391155.1 Mevalonate kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QBV5
NM_001420552.1 → NP_001407509.1 GHMP kinase C-terminal domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QBX2