Kat7 K(lysine) acetyltransferase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kat7provided by MGI
Official Full Name: K(lysine) acetyltransferase 7provided by MGI
Primary source: MGI:MGI:2182799
See related: Ensembl:ENSMUSG00000038909 AllianceGenome:MGI:2182799
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hbo1; Hboa; Myst2
Summary: Enables histone H3K14 acetyltransferase activity. Involved in several processes, including lymphocyte differentiation; positive regulation of erythrocyte differentiation; and positive regulation of macromolecule biosynthetic process. Located in nucleus. Part of histone H3-K14 acetyltransferase complex. Is expressed in central nervous system; early conceptus; genitourinary system; and limb. Orthologous to human KAT7 (lysine acetyltransferase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 20.1), placenta adult (RPKM 13.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 59.01 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (95162683..95201030, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (95271853..95310246, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circ-myh8 Promotes Pulmonary Hypertension by Recruiting KAT7 to Govern Hypoxia-Inducible Factor-1alpha Expression.
Title: Circ-myh8 Promotes Pulmonary Hypertension by Recruiting KAT7 to Govern Hypoxia-Inducible Factor-1α Expression.
The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance.
Title: The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance.
The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal.
Title: The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal.
The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis.
Title: The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis.
BRPF3-HUWE1-mediated regulation of MYST2 is required for differentiation and cell-cycle progression in embryonic stem cells.
Title: BRPF3-HUWE1-mediated regulation of MYST2 is required for differentiation and cell-cycle progression in embryonic stem cells.
MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes.
Title: MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes.
The Protective Effect of HBO1 on Cigarette Smoke Extract-Induced Apoptosis in Airway Epithelial Cells.
Title: The Protective Effect of HBO1 on Cigarette Smoke Extract-Induced Apoptosis in Airway Epithelial Cells.
The data provides a useful resource for exploring Myst2 and Niam essential cellular functions and should contribute to deeper understanding of organism early development and survival as well as cancer.
Title: Myst2/Kat7 histone acetyltransferase interaction proteomics reveals tumour-suppressor Niam as a novel binding partner in embryonic stem cells.
a nonredundant role for KAT7 in the maintenance of Histone h 3 lusine 14 acetylation, which is intimately linked with the ability to develop a normal immune system, is reported.
Title: Essential role for the histone acetyltransferase KAT7 in T cell development, fitness, and survival.
These results indicate that BRPF3 forms a functional tetrameric complex with HBO1 but is not required for mouse development and survival
Title: The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA replication origin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone H2AK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AK9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K122 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K14 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K14 acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3K14 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K14 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K18 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K23 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K23 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K27 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K36 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H4 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K12 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K12 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables histone H4K16 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H4K5 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K5 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H4K8 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K8 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication-dependent chromatin disassembly	ISO Inferred from Sequence Orthology more info
involved_in DNA replication-dependent chromatin disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in internal peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
involved_in internal peptidyl-lysine acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription, elongation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hematopoietic stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of hematopoietic stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated DNA replication initiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated DNA replication initiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of nucleotide-excision repair	ISO Inferred from Sequence Orthology more info
involved_in regulation of nucleotide-excision repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to actinomycin D	ISO Inferred from Sequence Orthology more info
involved_in response to anisomycin	ISO Inferred from Sequence Orthology more info
involved_in response to dithiothreitol	ISO Inferred from Sequence Orthology more info
involved_in response to hydroxyurea	ISO Inferred from Sequence Orthology more info
involved_in response to sorbitol	ISO Inferred from Sequence Orthology more info
involved_in stress-activated protein kinase signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation-coupled chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone H3-K14 acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone H3-K14 acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of histone H3-K14 acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: histone acetyltransferase KAT7

Names: MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST histone acetyltransferase 2; histone acetyltransferase MYST2; histone acetyltransferase binding to ORC1; lysine acetyltransferase 7

NP_001181932.1

EC 2.3.1.48

NP_001181933.1

EC 2.3.1.48

NP_001392123.1

EC 2.3.1.48

NP_001392124.1

EC 2.3.1.48

NP_001392125.1

EC 2.3.1.48

NP_001392126.1

EC 2.3.1.48

NP_001392127.1

EC 2.3.1.48

NP_001392128.1

EC 2.3.1.48

NP_001392129.1

EC 2.3.1.48

NP_001392130.1

EC 2.3.1.48

NP_001392131.1

EC 2.3.1.48

NP_001392132.1

EC 2.3.1.48

NP_001392133.1

EC 2.3.1.48

NP_001392134.1

EC 2.3.1.48

NP_001392135.1

EC 2.3.1.48

NP_001392136.1

EC 2.3.1.48

NP_001392137.1

EC 2.3.1.48

NP_001392138.1

EC 2.3.1.48

NP_001392139.1

EC 2.3.1.48

NP_001392140.1

EC 2.3.1.48

NP_001392141.1

EC 2.3.1.48

NP_001392142.1

EC 2.3.1.48

NP_001392143.1

EC 2.3.1.48

NP_001392144.1

EC 2.3.1.48

NP_001392145.1

EC 2.3.1.48

NP_001392146.1

EC 2.3.1.48

NP_001392147.1

EC 2.3.1.48

NP_001392148.1

EC 2.3.1.48

NP_001392149.1

EC 2.3.1.48

NP_001392150.1

EC 2.3.1.48

NP_001392151.1

EC 2.3.1.48

NP_001392152.1

EC 2.3.1.48

NP_001392153.1

EC 2.3.1.48

NP_001392154.1

EC 2.3.1.48

NP_001392155.1

EC 2.3.1.48

NP_001392156.1

EC 2.3.1.48

NP_808287.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001195003.2 → NP_001181932.1 histone acetyltransferase KAT7 isoform 1

See identical proteins and their annotated locations for NP_001181932.1

Status: VALIDATED

Source sequence(s)

AL627222

Consensus CDS

CCDS56799.1

UniProtKB/TrEMBL

A0AA74KSS6, Q1AJD0

Related

ENSMUSP00000103362.4, ENSMUST00000107734.10

Conserved Domains (3) summary

PLN00104
Location:324 → 609

PLN00104; MYST -like histone acetyltransferase; Provisional

pfam05109
Location:27 → 197

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01530
Location:184 → 212

zf-C2HC; Zinc finger, C2HC type
NM_001195004.2 → NP_001181933.1 histone acetyltransferase KAT7 isoform 2

See identical proteins and their annotated locations for NP_001181933.1

Status: VALIDATED

Source sequence(s)

AL627222

Consensus CDS

CCDS56798.1

UniProtKB/TrEMBL

A0AA74KSS6, Q3TD41

Related

ENSMUSP00000103361.4, ENSMUST00000107733.10

Conserved Domains (4) summary

PLN00104
Location:294 → 579

PLN00104; MYST -like histone acetyltransferase; Provisional

pfam05109
Location:27 → 197

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd16378
Location:209 → 262

CcmH_N; N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins

pfam01530
Location:184 → 212

zf-C2HC; Zinc finger, C2HC type
NM_001405194.1 → NP_001392123.1 histone acetyltransferase KAT7 isoform 4

Status: VALIDATED

Source sequence(s)

AL627222

UniProtKB/Swiss-Prot

Q5SVQ0, Q5SVQ1, Q5SVQ2, Q5SVQ3, Q5SVQ7, Q6PGC6, Q80Y65

Related

ENSMUSP00000090441.6, ENSMUST00000092766.12
NM_001405195.1 → NP_001392124.1 histone acetyltransferase KAT7 isoform 5

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405196.1 → NP_001392125.1 histone acetyltransferase KAT7 isoform 6

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405197.1 → NP_001392126.1 histone acetyltransferase KAT7 isoform 7

Status: VALIDATED

Source sequence(s)

AL627222

Related

ENSMUSP00000072416.6, ENSMUST00000072621.12
NM_001405198.1 → NP_001392127.1 histone acetyltransferase KAT7 isoform 8

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405199.1 → NP_001392128.1 histone acetyltransferase KAT7 isoform 9

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405200.1 → NP_001392129.1 histone acetyltransferase KAT7 isoform 10

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405201.1 → NP_001392130.1 histone acetyltransferase KAT7 isoform 11

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405202.1 → NP_001392131.1 histone acetyltransferase KAT7 isoform 12

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405203.1 → NP_001392132.1 histone acetyltransferase KAT7 isoform 13

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405204.1 → NP_001392133.1 histone acetyltransferase KAT7 isoform 14

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405205.1 → NP_001392134.1 histone acetyltransferase KAT7 isoform 15

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405206.1 → NP_001392135.1 histone acetyltransferase KAT7 isoform 16

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405207.1 → NP_001392136.1 histone acetyltransferase KAT7 isoform 17

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405208.1 → NP_001392137.1 histone acetyltransferase KAT7 isoform 18

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405209.1 → NP_001392138.1 histone acetyltransferase KAT7 isoform 19

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405210.1 → NP_001392139.1 histone acetyltransferase KAT7 isoform 20

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405211.1 → NP_001392140.1 histone acetyltransferase KAT7 isoform 21

Status: VALIDATED

Source sequence(s)

AL627222

UniProtKB/TrEMBL

Q3UGU8
NM_001405212.1 → NP_001392141.1 histone acetyltransferase KAT7 isoform 22

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405213.1 → NP_001392142.1 histone acetyltransferase KAT7 isoform 23

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405214.1 → NP_001392143.1 histone acetyltransferase KAT7 isoform 24

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405215.1 → NP_001392144.1 histone acetyltransferase KAT7 isoform 25

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405216.1 → NP_001392145.1 histone acetyltransferase KAT7 isoform 21

Status: VALIDATED

Source sequence(s)

AL627222

UniProtKB/TrEMBL

Q3UGU8
NM_001405217.1 → NP_001392146.1 histone acetyltransferase KAT7 isoform 21

Status: VALIDATED

Source sequence(s)

AL627222

UniProtKB/TrEMBL

Q3UGU8
NM_001405218.1 → NP_001392147.1 histone acetyltransferase KAT7 isoform 21

Status: VALIDATED

Source sequence(s)

AL627222

UniProtKB/TrEMBL

Q3UGU8
NM_001405219.1 → NP_001392148.1 histone acetyltransferase KAT7 isoform 21

Status: VALIDATED

Source sequence(s)

AL627222

UniProtKB/TrEMBL

Q3UGU8
NM_001405220.1 → NP_001392149.1 histone acetyltransferase KAT7 isoform 22

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405221.1 → NP_001392150.1 histone acetyltransferase KAT7 isoform 22

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405222.1 → NP_001392151.1 histone acetyltransferase KAT7 isoform 22

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405223.1 → NP_001392152.1 histone acetyltransferase KAT7 isoform 22

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405224.1 → NP_001392153.1 histone acetyltransferase KAT7 isoform 22

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405225.1 → NP_001392154.1 histone acetyltransferase KAT7 isoform 23

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405226.1 → NP_001392155.1 histone acetyltransferase KAT7 isoform 25

Status: VALIDATED

Source sequence(s)

AL627222
NM_001405227.1 → NP_001392156.1 histone acetyltransferase KAT7 isoform 26

Status: VALIDATED

Source sequence(s)

AL627222
NM_177619.4 → NP_808287.1 histone acetyltransferase KAT7 isoform 3

See identical proteins and their annotated locations for NP_808287.1

Status: VALIDATED

Source sequence(s)

AL627222

Consensus CDS

CCDS25275.1

UniProtKB/TrEMBL

A0AA74KSS6

Related

ENSMUSP00000099448.4, ENSMUST00000103159.10

Conserved Domains (2) summary

pfam01530
Location:125 → 153

zf-C2HC; Zinc finger, C2HC type

cl27485
Location:235 → 520

MOZ_SAS; MOZ/SAS family