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    Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 18537, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pcmt1provided by MGI
    Official Full Name
    protein-L-isoaspartate (D-aspartate) O-methyltransferase 1provided by MGI
    Primary source
    MGI:MGI:97502
    See related
    Ensembl:ENSMUSG00000019795 AllianceGenome:MGI:97502
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PIMT
    Summary
    Enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Acts upstream of or within protein methylation. Predicted to be located in several cellular components, including basolateral plasma membrane; brush border membrane; and perikaryon. Predicted to be active in cytoplasm. Orthologous to human PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 29.8), cerebellum adult (RPKM 17.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pcmt1 in Genome Data Viewer
    Location:
    10 A1; 10 2.26 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (7503608..7556922, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (7627845..7681337, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene UL16 binding protein 1 Neighboring gene predicted gene, 46209 Neighboring gene STARR-positive B cell enhancer ABC_E3874 Neighboring gene STARR-seq mESC enhancer starr_25682 Neighboring gene predicted gene 16254 Neighboring gene low density lipoprotein receptor-related protein 11 Neighboring gene RIKEN cDNA A630066F11 gene Neighboring gene STARR-positive B cell enhancer ABC_E3875 Neighboring gene nucleoporin 43 Neighboring gene large tumor suppressor Neighboring gene STARR-seq mESC enhancer starr_25689 Neighboring gene STARR-positive B cell enhancer ABC_E6817 Neighboring gene katanin p60 (ATPase-containing) subunit A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation. Kalailingam P, et al. EMBO Mol Med, 2023 Dec 7. PMID 37971164, Free PMC Article
    2. Genomic organization and tissue expression of the murine gene encoding the protein beta-aspartate methyltransferase. Romanik EA, et al. Gene, 1992 Sep 10. PMID 1511895
    3. Structural analysis of transcripts for the protein L-isoaspartyl methyltransferase reveals multiple transcription initiation sites and a distinct pattern of expression in mouse testis: identification of a 5'-flanking sequence with promoter activity. Galus A, et al. Arch Biochem Biophys, 1994 Aug 1. PMID 8037467
    4. Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice. Kim E, et al. Proc Natl Acad Sci U S A, 1997 Jun 10. PMID 9177182, Free PMC Article
    5. Deficiency in protein L-isoaspartyl methyltransferase results in a fatal progressive epilepsy. Yamamoto A, et al. J Neurosci, 1998 Mar 15. PMID 9482793, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PIMT is a novel and potent suppressor of endothelial activation.
      Title: PIMT is a novel and potent suppressor of endothelial activation.
    2. Loss of normal CKB structure and function contributes to the mechanisms by which isoaspartate accumulation leads to central nervous system dysfunction in the PIMT-Knockout mouse.
      Title: Isoaspartyl formation in creatine kinase B is associated with loss of enzymatic activity; implications for the linkage of isoaspartate accumulation and neurological dysfunction in the PIMT knockout mouse.
    3. PIMT levels may significantly influence the course of age-related central nervous system dysfunction.
      Title: Accelerated protein damage in brains of PIMT+/- mice; a possible model for the variability of cognitive decline in human aging.
    4. ERK2-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP at Ser298 augments hepatic gluconeogenesis.
      Title: ERK2-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP at Ser298 augments hepatic gluconeogenesis.
    5. PIMT knockout mice have perturbations in glutamate metabolism in the brain and die prematurely of epileptic seizures.
      Title: Brain proteomics supports the role of glutamate metabolism and suggests other metabolic alterations in protein l-isoaspartyl methyltransferase (PIMT)-knockout mice.
    6. synuclein is not a major target of PIMT in vivo
      Title: Considerations in the identification of endogenous substrates for protein L-isoaspartyl methyltransferase: the case of synuclein.
    7. Pcmt1-/- mice have an increased number of granule cells in the granule cell layer and hilus of the dentate gyrus.
      Title: Increased cell proliferation and granule cell number in the dentate gyrus of protein repair-deficient mice.
    8. An accumulation of isoaspartyl residues in cells of mice lacking the isoaspartyl repair enzyme PCMT alters the effector function of T lymphocytes leading to autoantibody production.
      Title: A failure to repair self-proteins leads to T cell hyperproliferation and autoantibody production.
    9. Recombinant adeno-PIMT improved the symptoms of PIMT-deficient mice in vivo, but only partially repaired IsoAsp in damaged proteins.
      Title: Adenoviral expression of protein-L-isoaspartyl methyltransferase (PIMT) partially attenuates the biochemical changes in PIMT-deficient mice.
    10. Synapsin I is a major endogenous substrate for Pcmt1 in the mouse brain.
      Title: Synapsin I is a major endogenous substrate for protein L-isoaspartyl methyltransferase in mammalian brain.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-adenosylhomocysteine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in S-adenosylmethionine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein-L-isoaspartate(D-aspartate) O-methyltransferase
    Names
    L-isoaspartyl protein carboxyl methyltransferase
    protein L-isoaspartyl/D-aspartyl methyltransferase
    protein carboxyl methyltransferase
    protein-beta-aspartate methyltransferase
    NP_001334157.2
    NP_001345576.2
    NP_001345578.1
    NP_001345580.1
    NP_001345581.1
    NP_001345582.1
    NP_001345583.1
    NP_001345586.1
    NP_001394120.1
    NP_001394121.1
    NP_001394122.1
    NP_001394123.1
    NP_001394124.1
    NP_001394125.1
    NP_001394126.1
    NP_001394127.1
    NP_001394128.1
    NP_001394129.1
    NP_001394130.1
    NP_001394131.1
    NP_001394132.1
    NP_001394133.1
    NP_001394134.1
    NP_001394135.1
    NP_001394138.1
    NP_001394139.1
    NP_001394140.1
    NP_001394141.1
    NP_001394142.1
    NP_001394144.1
    NP_001394145.1
    NP_001394146.1
    NP_001394147.1
    NP_001394148.1
    NP_001394149.1
    NP_001394150.1
    NP_001394156.1
    NP_001394157.1
    NP_001394158.1
    NP_001394159.1
    NP_001394160.1
    NP_001394161.1
    NP_001394162.1
    NP_001394163.1
    NP_001394164.1
    NP_001394165.1
    NP_001394166.1
    NP_001394177.1
    NP_001394178.1
    NP_001394179.1
    NP_001394180.1
    NP_001394181.1
    NP_001394182.1
    NP_001394183.1
    NP_001399029.1
    NP_032812.3
    XP_036011569.1
    XP_036011570.1
    XP_036011571.1
    XP_036011572.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347228.5 → NP_001334157.2  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156391
      Consensus CDS
      CCDS83677.1
      UniProtKB/TrEMBL
      Q8BPI6
      Related
      ENSMUSP00000123866.3, ENSMUST00000162606.8

    2. NM_001358647.3 → NP_001345576.2  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      F6V9F1

    3. NM_001358649.2 → NP_001345578.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6
      Conserved Domains (1) summary
      pfam01135
      Location:10 → 206
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    4. NM_001358651.2 → NP_001345580.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6
      Conserved Domains (1) summary
      pfam01135
      Location:1 → 190
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    5. NM_001358652.2 → NP_001345581.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6
      Conserved Domains (1) summary
      pfam01135
      Location:1 → 190
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    6. NM_001358653.2 → NP_001345582.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6
      Conserved Domains (1) summary
      pfam01135
      Location:1 → 190
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    7. NM_001358654.2 → NP_001345583.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC156391
      Conserved Domains (1) summary
      pfam01135
      Location:1 → 153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    8. NM_001358657.2 → NP_001345586.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC156391
      Conserved Domains (1) summary
      pfam01135
      Location:1 → 153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    9. NM_001407191.1 → NP_001394120.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    10. NM_001407192.1 → NP_001394121.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    11. NM_001407193.1 → NP_001394122.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    12. NM_001407194.1 → NP_001394123.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    13. NM_001407195.1 → NP_001394124.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    14. NM_001407196.1 → NP_001394125.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    15. NM_001407197.1 → NP_001394126.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC156391

    16. NM_001407198.1 → NP_001394127.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC156391

    17. NM_001407199.1 → NP_001394128.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    18. NM_001407200.1 → NP_001394129.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC156391

    19. NM_001407201.1 → NP_001394130.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    20. NM_001407202.1 → NP_001394131.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 23

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      F6V9F1

    21. NM_001407203.1 → NP_001394132.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 28

      Status: VALIDATED

      Source sequence(s)
      AC156391

    22. NM_001407204.1 → NP_001394133.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 24

      Status: VALIDATED

      Source sequence(s)
      AC156391

    23. NM_001407205.1 → NP_001394134.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    24. NM_001407206.1 → NP_001394135.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 31

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    25. NM_001407209.1 → NP_001394138.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 29

      Status: VALIDATED

      Source sequence(s)
      AC156391

    26. NM_001407210.1 → NP_001394139.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 25

      Status: VALIDATED

      Source sequence(s)
      AC156391

    27. NM_001407211.1 → NP_001394140.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 21

      Status: VALIDATED

      Source sequence(s)
      AC156391

    28. NM_001407212.1 → NP_001394141.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    29. NM_001407213.1 → NP_001394142.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    30. NM_001407215.1 → NP_001394144.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    31. NM_001407216.1 → NP_001394145.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    32. NM_001407217.1 → NP_001394146.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    33. NM_001407218.1 → NP_001394147.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    34. NM_001407219.1 → NP_001394148.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC156391

    35. NM_001407220.1 → NP_001394149.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 20

      Status: VALIDATED

      Source sequence(s)
      AC156391

    36. NM_001407221.1 → NP_001394150.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 20

      Status: VALIDATED

      Source sequence(s)
      AC156391

    37. NM_001407227.1 → NP_001394156.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 22

      Status: VALIDATED

      Source sequence(s)
      AC156391

    38. NM_001407228.1 → NP_001394157.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 22

      Status: VALIDATED

      Source sequence(s)
      AC156391

    39. NM_001407229.1 → NP_001394158.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC156391

    40. NM_001407230.1 → NP_001394159.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC156391

    41. NM_001407231.1 → NP_001394160.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC156391

    42. NM_001407232.1 → NP_001394161.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC156391

    43. NM_001407233.1 → NP_001394162.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC156391

    44. NM_001407234.1 → NP_001394163.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    45. NM_001407235.1 → NP_001394164.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    46. NM_001407236.1 → NP_001394165.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 28

      Status: VALIDATED

      Source sequence(s)
      AC156391

    47. NM_001407237.1 → NP_001394166.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 28

      Status: VALIDATED

      Source sequence(s)
      AC156391

    48. NM_001407248.1 → NP_001394177.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    49. NM_001407249.1 → NP_001394178.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    50. NM_001407250.1 → NP_001394179.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    51. NM_001407251.1 → NP_001394180.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    52. NM_001407252.1 → NP_001394181.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      Q8BPI6

    53. NM_001407253.1 → NP_001394182.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 26

      Status: VALIDATED

      Source sequence(s)
      AC156391

    54. NM_001407254.1 → NP_001394183.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 27

      Status: VALIDATED

      Source sequence(s)
      AC156391

    55. NM_001412100.1 → NP_001399029.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 30

      Status: VALIDATED

      Source sequence(s)
      AC156391
      UniProtKB/TrEMBL
      F6V9F1
      Related
      ENSMUSP00000123758.2, ENSMUST00000161428.8

    56. NM_008786.6 → NP_032812.3  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156391
      Consensus CDS
      CCDS23687.2
      UniProtKB/Swiss-Prot
      P23506, Q810R4
      UniProtKB/TrEMBL
      Q545L9, Q8BPI6
      Related
      ENSMUSP00000124932.3, ENSMUST00000159917.8

    RNA

    1. NR_176302.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156391

    2. NR_176303.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156391

    3. NR_176304.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156391

    4. NR_176305.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156391

    5. NR_176306.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156391

    6. NR_176307.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156391

    7. NR_176308.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156391

    8. NR_176309.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156391

    9. NR_176310.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156391

    10. NR_176311.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156391

    11. NR_176312.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156391

    12. NR_176313.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156391

    13. NR_176314.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156391

    14. NR_176315.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156391

    15. NR_176316.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156391

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      7503608..7556922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155676.1 → XP_036011569.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X5

      Conserved Domains (1) summary
      pfam01135
      Location:1 → 153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    2. XM_036155679.1 → XP_036011572.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X5

      Conserved Domains (1) summary
      pfam01135
      Location:1 → 153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    3. XM_036155677.1 → XP_036011570.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X5

      Conserved Domains (1) summary
      pfam01135
      Location:1 → 153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    4. XM_036155678.1 → XP_036011571.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X5

      Conserved Domains (1) summary
      pfam01135
      Location:1 → 153
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_033219.1: Suppressed sequence

      Description
      NR_033219.1: This RefSeq was removed because the gene was discontinued.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23506.3 GenPept UniProtKB/Swiss-Prot:P23506

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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