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    Slc35b2 solute carrier family 35, member B2 [ Mus musculus (house mouse) ]

    Gene ID: 73836, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc35b2provided by MGI
    Official Full Name
    solute carrier family 35, member B2provided by MGI
    Primary source
    MGI:MGI:1921086
    See related
    Ensembl:ENSMUSG00000037089 AllianceGenome:MGI:1921086
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAPST1; Slc35b1; 1110003M08Rik
    Summary
    Enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity. Involved in 5'-adenylyl sulfate transmembrane transport and peptidyl-tyrosine sulfation. Is active in Golgi membrane and trans-Golgi network. Is expressed in several structures, including cerebral cortex ventricular layer; craniocervical region bone; otic capsule; retina nuclear layer; and shoulder bone. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 26. Orthologous to human SLC35B2 (solute carrier family 35 member B2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 50.2), colon adult (RPKM 39.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc35b2 in Genome Data Viewer
    Location:
    17 B3; 17 22.59 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (45874844..45878597)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (45563913..45567671)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene t-complex-associated testis expressed 1 Neighboring gene transmembrane protein 151B Neighboring gene STARR-positive B cell enhancer ABC_E7533 Neighboring gene STARR-positive B cell enhancer ABC_E961 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45695258-45695367 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon Neighboring gene STARR-positive B cell enhancer ABC_E10954 Neighboring gene heat shock protein 90 alpha (cytosolic), class B member 1 Neighboring gene STARR-positive B cell enhancer ABC_E9954 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45710735-45710975 Neighboring gene predicted gene, 35399

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The 3'-phosphoadenosine 5'-phosphosulfate transporters, PAPST1 and 2, contribute to the maintenance and differentiation of mouse embryonic stem cells. Sasaki N, et al. PLoS One, 2009 Dec 11. PMID 20011239, Free PMC Article
    2. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAPST-dependent sulfation of heparan sulfate or chondroitin sulfate chains regulates the extrinsic signaling required for the maintenance and normal differentiation of mouse embryonic stem cells.[PAPST1, PAPST2]
      Title: The 3'-phosphoadenosine 5'-phosphosulfate transporters, PAPST1 and 2, contribute to the maintenance and differentiation of mouse embryonic stem cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-phospho-5'-adenylyl sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 3'-phosphoadenosine 5'-phosphosulfate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 3'-phosphoadenosine 5'-phosphosulfate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in 5'-adenylyl sulfate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chondroitin sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondroitin sulfate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-tyrosine sulfation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenosine 3'-phospho 5'-phosphosulfate transporter 1
    Names
    PAPS transporter 1
    solute carrier family 35, member B1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357105.1 → NP_001344034.1  adenosine 3'-phospho 5'-phosphosulfate transporter 1

      Status: VALIDATED

      Source sequence(s)
      AI842275, AK144403, AK152362, BB855705, BB871150
      Consensus CDS
      CCDS37630.2
      UniProtKB/Swiss-Prot
      Q3U221, Q8BTH2, Q91ZN5
      UniProtKB/TrEMBL
      Q3U399, Q3U866
      Related
      ENSMUSP00000153367.2, ENSMUST00000224905.2
      Conserved Domains (1) summary
      pfam08449
      Location:111 → 412
      UAA; UAA transporter family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      45874844..45878597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160806.1 → XP_036016699.1  adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform X1

      UniProtKB/TrEMBL
      Q3TJQ2
      Conserved Domains (1) summary
      pfam08449
      Location:31 → 326
      UAA; UAA transporter family

    2. XM_036160807.1 → XP_036016700.1  adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform X2

      UniProtKB/TrEMBL
      Q3TJQ2
      Related
      ENSMUSP00000153631.2, ENSMUST00000223987.2
      Conserved Domains (1) summary
      pfam08449
      Location:106 → 407
      UAA; UAA transporter family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_028662.2: Suppressed sequence

      Description
      NM_028662.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZN5.1 GenPept UniProtKB/Swiss-Prot:Q91ZN5

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