Rbm5 RNA binding motif protein 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbm5provided by MGI
Official Full Name: RNA binding motif protein 5provided by MGI
Primary source: MGI:MGI:1933204
See related: Ensembl:ENSMUSG00000032580 AllianceGenome:MGI:1933204
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D030069N10Rik
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in positive regulation of apoptotic process; regulation of alternative mRNA splicing, via spliceosome; and spliceosomal complex assembly. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in nucleus. Is expressed in central nervous system; lung; sensory organ; and testis. Orthologous to human RBM5 (RNA binding motif protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E14 (RPKM 44.1), CNS E11.5 (RPKM 42.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 59.07 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (107617694..107648228, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (107740495..107771007, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gene knockout of RNA binding motif 5 in the brain alters RIMS2 protein homeostasis in the cerebellum and Hippocampus and exacerbates behavioral deficits after a TBI in mice.
Title: Gene knockout of RNA binding motif 5 in the brain alters RIMS2 protein homeostasis in the cerebellum and Hippocampus and exacerbates behavioral deficits after a TBI in mice.
Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington's disease.
Title: Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington's disease.
RBM5 can inhibit the apoptosis of bone cells by promoting the expression of beta-catenin and can be used as a biomarker for fracture healing.
Title: RBM5-AS1 participates in fracture healing and inhibits apoptosis of bone cells through the up-regulation of β-catenin.
Expression of Rbm5 and Rbm10 RNA remained constant during C2C12 myogenesis, but protein levels significantly decreased.
Title: Co- and post-transcriptional regulation of Rbm5 and Rbm10 in mouse cells as evidenced by tissue-specific, developmental and disease-associated variation of splice variant and protein expression levels.
The RBM5/10 staining was higher 48 to 72 hours after traumatic brain injury and appeared to be increased in neuronal nuclei of the hippocampus.
Title: The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice.
Our findings also suggest that the second RRM of RBM5 is pivotal for appropriate pre-mRNA splicing.
Title: RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rbm5 (e-PCR), detects polymorphism
- UniSTS:479235

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in spliceosomal complex assembly	ISO Inferred from Sequence Orthology more info
involved_in spliceosomal complex assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RNA-binding protein 5

Names: putative tumor suppressor LUCA15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359524.2 → NP_001346453.1 RNA-binding protein 5 isoform 2

Status: VALIDATED

Source sequence(s)

AC152718

Consensus CDS

CCDS90660.1

Related

ENSMUSP00000035199.7, ENSMUST00000035199.13

Conserved Domains (6) summary

cd12752
Location:93 → 179

RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)

cd12755
Location:229 → 314

RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)

sd00025
Location:185 → 204

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam00641
Location:181 → 210

zf-RanBP; Zn-finger in Ran binding protein and others

cd16168
Location:455 → 509

OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins

pfam01585
Location:742 → 786

G-patch; G-patch domain
NM_001359525.2 → NP_001346454.1 RNA-binding protein 5 isoform 1

Status: VALIDATED

Source sequence(s)

AC152718

Consensus CDS

CCDS23506.1

UniProtKB/Swiss-Prot

Q3UZ19, Q91YE7, Q99KV9

Conserved Domains (6) summary

cd12752
Location:93 → 179

RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)

cd12755
Location:229 → 314

RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)

sd00025
Location:185 → 204

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16168
Location:455 → 510

OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins

pfam00641
Location:183 → 210

zf-RanBP; Zn-finger in Ran binding protein and others

pfam01585
Location:743 → 785

G-patch; G-patch domain
NM_001359526.2 → NP_001346455.1 RNA-binding protein 5 isoform 1

Status: VALIDATED

Source sequence(s)

AC152718

Consensus CDS

CCDS23506.1

UniProtKB/Swiss-Prot

Q3UZ19, Q91YE7, Q99KV9

Conserved Domains (6) summary

cd12752
Location:93 → 179

RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)

cd12755
Location:229 → 314

RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)

sd00025
Location:185 → 204

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16168
Location:455 → 510

OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins

pfam00641
Location:183 → 210

zf-RanBP; Zn-finger in Ran binding protein and others

pfam01585
Location:743 → 785

G-patch; G-patch domain
NM_148930.4 → NP_683732.1 RNA-binding protein 5 isoform 1

See identical proteins and their annotated locations for NP_683732.1

Status: VALIDATED

Source sequence(s)

AC152718

Consensus CDS

CCDS23506.1

UniProtKB/Swiss-Prot

Q3UZ19, Q91YE7, Q99KV9

Related

ENSMUSP00000138379.2, ENSMUST00000182659.8

Conserved Domains (6) summary

cd12752
Location:93 → 179

RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)

cd12755
Location:229 → 314

RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)

sd00025
Location:185 → 204

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16168
Location:455 → 510

OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins

pfam00641
Location:183 → 210

zf-RanBP; Zn-finger in Ran binding protein and others

pfam01585
Location:743 → 785

G-patch; G-patch domain

RNA

NR_153190.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC152718
NR_153191.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC152718

Related

ENSMUST00000182371.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

107617694..107648228 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511872.3 → XP_006511935.1 RNA-binding protein 5 isoform X1

See identical proteins and their annotated locations for XP_006511935.1

UniProtKB/Swiss-Prot

Q3UZ19, Q91YE7, Q99KV9

Conserved Domains (6) summary

cd12752
Location:93 → 179

RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)

cd12755
Location:229 → 314

RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)

sd00025
Location:185 → 204

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16168
Location:455 → 510

OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins

pfam00641
Location:183 → 210

zf-RanBP; Zn-finger in Ran binding protein and others

pfam01585
Location:743 → 785

G-patch; G-patch domain
XM_006511875.3 → XP_006511938.1 RNA-binding protein 5 isoform X4

See identical proteins and their annotated locations for XP_006511938.1

Conserved Domains (3) summary

cd16168
Location:208 → 263

OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins

pfam01585
Location:496 → 538

G-patch; G-patch domain

cl17169
Location:1 → 67

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030244735.2 → XP_030100595.1 RNA-binding protein 5 isoform X3

Conserved Domains (5) summary

cd12755
Location:57 → 142

RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)

sd00025
Location:13 → 32

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16168
Location:283 → 337

OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins

pfam00641
Location:11 → 38

zf-RanBP; Zn-finger in Ran binding protein and others

pfam01585
Location:570 → 612

G-patch; G-patch domain
XM_030244732.2 → XP_030100592.1 RNA-binding protein 5 isoform X2

Conserved Domains (5) summary

cd12755
Location:57 → 142

RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)

sd00025
Location:13 → 32

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16168
Location:283 → 338

OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins

pfam00641
Location:11 → 38

zf-RanBP; Zn-finger in Ran binding protein and others

pfam01585
Location:571 → 613

G-patch; G-patch domain
XM_030244734.2 → XP_030100594.1 RNA-binding protein 5 isoform X2

Conserved Domains (5) summary

cd12755
Location:57 → 142

RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)

sd00025
Location:13 → 32

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16168
Location:283 → 338

OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins

pfam00641
Location:11 → 38

zf-RanBP; Zn-finger in Ran binding protein and others

pfam01585
Location:571 → 613

G-patch; G-patch domain
XM_030244733.2 → XP_030100593.1 RNA-binding protein 5 isoform X2

Conserved Domains (5) summary

cd12755
Location:57 → 142

RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)

sd00025
Location:13 → 32

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd16168
Location:283 → 338

OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins

pfam00641
Location:11 → 38

zf-RanBP; Zn-finger in Ran binding protein and others

pfam01585
Location:571 → 613

G-patch; G-patch domain
XM_006511876.1 → XP_006511939.1 RNA-binding protein 5 isoform X4

See identical proteins and their annotated locations for XP_006511939.1

Related

ENSMUST00000194801.6

Conserved Domains (3) summary

cd16168
Location:208 → 263

OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins

pfam01585
Location:496 → 538

G-patch; G-patch domain

cl17169
Location:1 → 67

RRM_SF; RNA recognition motif (RRM) superfamily