Arhgap5 Rho GTPase activating protein 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap5provided by MGI
Official Full Name: Rho GTPase activating protein 5provided by MGI
Primary source: MGI:MGI:1332637
See related: Ensembl:ENSMUSG00000035133 AllianceGenome:MGI:1332637
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p190B; p190-B
Summary: Predicted to enable GTPase activator activity and SH2 domain binding activity. Acts upstream of or within several processes, including positive regulation of epithelial cell migration; positive regulation of mesenchymal cell proliferation; and regulation of cell size. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ARHGAP5 (Rho GTPase activating protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 9.8), frontal lobe adult (RPKM 6.6) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C1; 12 22.16 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (52550555..52618761)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (52503763..52571978)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study suggests a link between p190-B-RhoGAP and non-canonical TGF-beta signaling in hematopoietic stem and progenitor cell differentiation.
Title: p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation.
Loss of p190-B expression is associated with defective hematopoiesis.
Title: p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment.
Rac1 activity and oxidative stress are elevated in tumors expressing exogenous p190B suggesting that p190B may promote tumorigenesis through a Rac1/ROS dependent mechanism.
Title: P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis.
p190B haploinsufficiency in the epithelium inhibits MMTV-Neu tumor initiation. p190B deficiency in the vasculature is responsible, in part, for the inhibition of MMTV-Neu tumor progression.
Title: Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression.
Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.
Title: Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.
IGF signaling through p190-B and IRS proteins is critical for mammary bud formation and ensuing epithelial-mesenchymal interactions necessary to sustain mammary bud morphogenesis
Title: Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development.
Mice lacking the Rho-inhibitory protein, p190-B RhoGAP, are 30% reduced in size and exhibit developmental defects strikingly similar to those seen in mice lacking the CREB transcription factor.
Title: Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development.
Results suggest that p190-B regulates ductal morphogenesis, at least in part, by modulating the IGF signaling axis
Title: p190-B RhoGAP regulates mammary ductal morphogenesis.
precise control of p190-B Rho GTPase-activating protein activity is critical for normal branching morphogenesis during mammary gland development
Title: P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236844

Arhgap5 (e-PCR), detects polymorphism
- UniSTS:526932

AU014947 (e-PCR)
- UniSTS:207457

Arhgap5 (e-PCR), detects polymorphism
- UniSTS:506738

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables SH2 domain binding	IEA Inferred from Electronic Annotation more info
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell size	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rho GTPase-activating protein 5

Names: rho-type GTPase-activating protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001408721.1 → NP_001395650.1 rho GTPase-activating protein 5 isoform 1

Status: VALIDATED

Source sequence(s)

AC114002, AC155819

UniProtKB/Swiss-Prot

E9PYT0, E9Q0L8, P97393

Related

ENSMUSP00000106353.2, ENSMUST00000110725.2
NM_001408722.1 → NP_001395651.1 rho GTPase-activating protein 5 isoform 1

Status: VALIDATED

Source sequence(s)

AC114002, AC155819

UniProtKB/Swiss-Prot

E9PYT0, E9Q0L8, P97393

Related

ENSMUSP00000151809.2, ENSMUST00000219443.2
NM_001408723.1 → NP_001395652.1 rho GTPase-activating protein 5 isoform 2

Status: VALIDATED

Source sequence(s)

AC114002, AC155819
NM_001408724.1 → NP_001395653.1 rho GTPase-activating protein 5 isoform 2

Status: VALIDATED

Source sequence(s)

AC114002, AC155819
NM_009706.3 → NP_033836.2 rho GTPase-activating protein 5 isoform 1

See identical proteins and their annotated locations for NP_033836.2

Status: VALIDATED

Source sequence(s)

AC114002, AC155819

Consensus CDS

CCDS36443.1

UniProtKB/Swiss-Prot

E9PYT0, E9Q0L8, P97393

Conserved Domains (4) summary

smart00441
Location:428 → 481

FF; Contains two conserved F residues

cd04373
Location:1261 → 1445

RhoGAP_p190; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an ...

pfam16512
Location:260 → 338

RhoGAP-FF1; p190-A and -B Rho GAPs FF domain

cl38936
Location:31 → 246

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

NR_176796.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC114002, AC155819
NR_176797.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC114002, AC155819