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    Ect2 ect2 oncogene [ Mus musculus (house mouse) ]

    Gene ID: 13605, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ect2provided by MGI
    Official Full Name
    ect2 oncogeneprovided by MGI
    Primary source
    MGI:MGI:95281
    See related
    Ensembl:ENSMUSG00000027699 AllianceGenome:MGI:95281
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables small GTPase binding activity. Involved in positive regulation of neuron differentiation and positive regulation of protein import into nucleus. Acts upstream of or within cell morphogenesis. Located in cytoplasm and nucleus. Is expressed in brain and liver. Orthologous to human ECT2 (epithelial cell transforming 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 13.0), liver E14 (RPKM 11.1) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ect2 in Genome Data Viewer
    Location:
    3 A3; 3 10.82 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (27151371..27207971, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (27097222..27154253, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 16 Neighboring gene predicted gene, 32458 Neighboring gene STARR-seq mESC enhancer starr_07220 Neighboring gene STARR-seq mESC enhancer starr_07221 Neighboring gene STARR-seq mESC enhancer starr_07222 Neighboring gene ribosomal protein L3 pseudogene Neighboring gene RIKEN cDNA 1700125G22 gene Neighboring gene predicted gene, 25152 Neighboring gene STARR-seq mESC enhancer starr_07226 Neighboring gene STARR-seq mESC enhancer starr_07227 Neighboring gene STARR-seq mESC enhancer starr_07228 Neighboring gene STARR-seq mESC enhancer starr_07232 Neighboring gene STARR-positive B cell enhancer ABC_E6045 Neighboring gene neutral cholesterol ester hydrolase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA4037

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bicellular tight junction assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydrogen peroxide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to ionizing radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mitotic cytokinetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitotic cytokinetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of attachment of spindle microtubules to kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cytokinesis, actomyosin contractile ring assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in bicellular tight junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of centralspindlin complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of centralspindlin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cleavage furrow ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein ECT2
    Names
    epithelial cell-transforming sequence 2 oncogene

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177625.2NP_001171096.1  protein ECT2 isoform 2

      See identical proteins and their annotated locations for NP_001171096.1

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      Consensus CDS
      CCDS50875.1
      UniProtKB/TrEMBL
      A0A2X0SFE3
      Related
      ENSMUSP00000135740.3, ENSMUST00000176242.9
      Conserved Domains (4) summary
      smart00325
      Location:425609
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:600773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:239318
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:145220
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    2. NM_001177626.2NP_001171097.1  protein ECT2 isoform 2

      See identical proteins and their annotated locations for NP_001171097.1

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      Consensus CDS
      CCDS50875.1
      UniProtKB/TrEMBL
      A0A2X0SFE3
      Related
      ENSMUSP00000103933.3, ENSMUST00000108298.9
      Conserved Domains (4) summary
      smart00325
      Location:425609
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:600773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:239318
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:145220
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    3. NM_001409697.1NP_001396626.1  protein ECT2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/TrEMBL
      A0A2X0SFE3
    4. NM_001409704.1NP_001396633.1  protein ECT2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/Swiss-Prot
      Q07139, Q3TZP2, Q5DTR8, Q80VE4, Q8CIH2, Q8K2A0, Q8R3E2
      UniProtKB/TrEMBL
      A0A2X0SFE3
    5. NM_001409705.1NP_001396634.1  protein ECT2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/Swiss-Prot
      Q07139, Q3TZP2, Q5DTR8, Q80VE4, Q8CIH2, Q8K2A0, Q8R3E2
      UniProtKB/TrEMBL
      A0A2X0SFE3
    6. NM_001409706.1NP_001396635.1  protein ECT2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/Swiss-Prot
      Q07139, Q3TZP2, Q5DTR8, Q80VE4, Q8CIH2, Q8K2A0, Q8R3E2
      UniProtKB/TrEMBL
      A0A2X0SFE3
    7. NM_001409707.1NP_001396636.1  protein ECT2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/TrEMBL
      A0A2X0SFE3
    8. NM_001409708.1NP_001396637.1  protein ECT2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/Swiss-Prot
      Q07139, Q3TZP2, Q5DTR8, Q80VE4, Q8CIH2, Q8K2A0, Q8R3E2
      UniProtKB/TrEMBL
      A0A2X0SFE3
    9. NM_001409709.1NP_001396638.1  protein ECT2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/TrEMBL
      A0A2X0SFE3
    10. NM_001409710.1NP_001396639.1  protein ECT2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/TrEMBL
      A0A2X0SFE3
    11. NM_001409711.1NP_001396640.1  protein ECT2 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/TrEMBL
      A0A2X0SFE3
    12. NM_001409712.1NP_001396641.1  protein ECT2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/TrEMBL
      A0A2X0SFE3
    13. NM_001409713.1NP_001396642.1  protein ECT2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/TrEMBL
      A0A2X0SFE3
    14. NM_001409714.1NP_001396643.1  protein ECT2 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/TrEMBL
      A0A2X0SFE3
    15. NM_001409715.1NP_001396644.1  protein ECT2 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/TrEMBL
      A0A2X0SFE3
    16. NM_001409716.1NP_001396645.1  protein ECT2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/TrEMBL
      A0A2X0SFE3
    17. NM_001409717.1NP_001396646.1  protein ECT2 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/TrEMBL
      A0A2X0SFE3
    18. NM_001409718.1NP_001396647.1  protein ECT2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/TrEMBL
      A0A2X0SFE3
    19. NM_001409719.1NP_001396648.1  protein ECT2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/TrEMBL
      A0A2X0SFE3
    20. NM_001409720.1NP_001396649.1  protein ECT2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/TrEMBL
      A0A2X0SFE3
    21. NM_001409721.1NP_001396650.1  protein ECT2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/TrEMBL
      A0A2X0SFE3
    22. NM_001409722.1NP_001396651.1  protein ECT2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/TrEMBL
      A0A2X0SFE3
    23. NM_001409723.1NP_001396652.1  protein ECT2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/TrEMBL
      A0A2X0SFE3
    24. NM_001409724.1NP_001396653.1  protein ECT2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      UniProtKB/TrEMBL
      A0A2X0SFE3
    25. NM_001409725.1NP_001396654.1  protein ECT2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
    26. NM_007900.4NP_031926.2  protein ECT2 isoform 1

      See identical proteins and their annotated locations for NP_031926.2

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC165280
      Consensus CDS
      CCDS17270.2
      UniProtKB/Swiss-Prot
      Q07139, Q3TZP2, Q5DTR8, Q80VE4, Q8CIH2, Q8K2A0, Q8R3E2
      UniProtKB/TrEMBL
      A0A2X0SFE3
      Related
      ENSMUSP00000103935.2, ENSMUST00000108300.8
      Conserved Domains (5) summary
      PRK09630
      Location:71125
      PRK09630; DNA topoisomerase IV subunit A; Provisional
      smart00325
      Location:456640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:270349
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:176251
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      27151371..27207971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)