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    Pde9a phosphodiesterase 9A [ Mus musculus (house mouse) ]

    Gene ID: 18585, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pde9aprovided by MGI
    Official Full Name
    phosphodiesterase 9Aprovided by MGI
    Primary source
    MGI:MGI:1277179
    See related
    Ensembl:ENSMUSG00000041119 AllianceGenome:MGI:1277179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PDE9A1
    Summary
    Enables 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cGMP catabolic process and positive regulation of cardiac muscle hypertrophy. Predicted to be located in several cellular components, including nucleoplasm; perikaryon; and sarcolemma. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PDE9A (phosphodiesterase 9A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in colon adult (RPKM 62.7), large intestine adult (RPKM 61.1) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pde9a in Genome Data Viewer
    Location:
    17 B1; 17 16.23 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (31605079..31695284)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31386105..31476309)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ubiquitin associated and SH3 domain containing, A Neighboring gene radial spoke head 1 homolog (Chlamydomonas) Neighboring gene STARR-seq mESC enhancer starr_42328 Neighboring gene solute carrier family 37 (glycerol-3-phosphate transporter), member 1 Neighboring gene predicted gene, 30139 Neighboring gene STARR-seq mESC enhancer starr_42332 Neighboring gene STARR-seq mESC enhancer starr_42334 Neighboring gene predicted gene 9902 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31649222-31649405 Neighboring gene STARR-positive B cell enhancer ABC_E3197 Neighboring gene WD repeat domain 4 Neighboring gene NADH:ubiquinone oxidoreductase core subunit V3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cGMP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cGMP catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cGMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cGMP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cGMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cGMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neural precursor cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle hypertrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
    NP_001157220.1
    NP_001397616.1
    NP_001397617.1
    NP_001397618.1
    NP_001397619.1
    NP_001397620.1
    NP_032830.3
    XP_036016291.1
    XP_036016292.1
    XP_036016293.1
    XP_036016294.1
    XP_036016295.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163748.2NP_001157220.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 1

      See identical proteins and their annotated locations for NP_001157220.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC154652, AC166172
      Consensus CDS
      CCDS28605.1
      UniProtKB/Swiss-Prot
      O70628
      UniProtKB/TrEMBL
      Q8BSU4
      Related
      ENSMUSP00000117611.2, ENSMUST00000127929.8
      Conserved Domains (1) summary
      pfam00233
      Location:250478
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    2. NM_001410687.1NP_001397616.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154652, AC166172
    3. NM_001410688.1NP_001397617.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154652, AC166172
      Related
      ENSMUSP00000158101.2, ENSMUST00000235719.2
    4. NM_001410689.1NP_001397618.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC166172
      UniProtKB/TrEMBL
      D3Z408
    5. NM_001410690.1NP_001397619.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC166172
      UniProtKB/TrEMBL
      D3Z408
      Related
      ENSMUSP00000116724.3, ENSMUST00000136384.9
    6. NM_001410691.1NP_001397620.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154652, AC166172
      UniProtKB/TrEMBL
      D3Z408
      Related
      ENSMUSP00000157420.2, ENSMUST00000236454.2
    7. NM_008804.5NP_032830.3  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform 1

      See identical proteins and their annotated locations for NP_032830.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC154652, AC166172
      Consensus CDS
      CCDS28605.1
      UniProtKB/Swiss-Prot
      O70628
      UniProtKB/TrEMBL
      Q8BSU4
      Related
      ENSMUSP00000038005.6, ENSMUST00000047168.13
      Conserved Domains (1) summary
      pfam00233
      Location:250478
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RNA

    1. NR_177107.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154652, AC166172
    2. NR_177108.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154652, AC166172
      Related
      ENSMUST00000124902.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      31605079..31695284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160399.1XP_036016292.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

      UniProtKB/TrEMBL
      A0A494BAJ0
      Related
      ENSMUSP00000158058.2, ENSMUST00000235639.2
      Conserved Domains (1) summary
      pfam00233
      Location:250478
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    2. XM_036160398.1XP_036016291.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

      UniProtKB/TrEMBL
      A0A494BAJ0
      Conserved Domains (1) summary
      pfam00233
      Location:250478
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    3. XM_036160401.1XP_036016294.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

      UniProtKB/TrEMBL
      A0A494BBD2
      Conserved Domains (1) summary
      pfam00233
      Location:103331
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    4. XM_036160400.1XP_036016293.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

      UniProtKB/TrEMBL
      A0A494BBD2
      Conserved Domains (1) summary
      pfam00233
      Location:103331
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    5. XM_036160402.1XP_036016295.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

      UniProtKB/TrEMBL
      A0A494BBD2
      Conserved Domains (1) summary
      pfam00233
      Location:103331
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase