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    Hmgb3 high mobility group box 3 [ Mus musculus (house mouse) ]

    Gene ID: 15354, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hmgb3provided by MGI
    Official Full Name
    high mobility group box 3provided by MGI
    Primary source
    MGI:MGI:1098219
    See related
    Ensembl:ENSMUSG00000015217 AllianceGenome:MGI:1098219
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hmg4; Hmg2a
    Summary
    Enables DNA binding activity and RNA binding activity. Acts upstream of or within negative regulation of B cell differentiation and negative regulation of myeloid cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; ear; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in syndromic microphthalmia 13. Orthologous to human HMGB3 (high mobility group box 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 187.0), CNS E14 (RPKM 108.6) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hmgb3 in Genome Data Viewer
    Location:
    X A7.3; X 36.92 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (70599523..70604261)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (71555917..71560673)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47324 Neighboring gene CD99 antigen-like 2 Neighboring gene ribosomal protein L36 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chrX:68808842-68809143 Neighboring gene STARR-seq mESC enhancer starr_47325 Neighboring gene STARR-seq mESC enhancer starr_47326 Neighboring gene G-protein-coupled receptor 50 Neighboring gene ribosomal protein L30, pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hmgb3 deficiency deregulates proliferation and differentiation of common lymphoid and myeloid progenitors. Nemeth MJ, et al. Blood, 2005 Jan 15. PMID 15358624
    2. Hmgb3 regulates the balance between hematopoietic stem cell self-renewal and differentiation. Nemeth MJ, et al. Proc Natl Acad Sci U S A, 2006 Sep 12. PMID 16945912, Free PMC Article
    3. Isolation of human and mouse HMG2a cDNAs: evidence for an HMG2a-specific 3' untranslated region. Wilke K, et al. Gene, 1997 Oct 1. PMID 9370291
    4. Hmgb3 Induces the Differentiation of Uterine Stromal Cells Through Targeting Ptn. Wang K, et al. Reprod Sci, 2019 Jul. PMID 30081728
    5. Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas. Fedele M, et al. Oncogene, 2002 May 9. PMID 12082634

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hmgb3 may play an important role during embryo implantation and decidualization. Pleiotropin is a downstream target of Hmgb3 in the differentiation of uterine stromal cells.
      Title: Hmgb3 Induces the Differentiation of Uterine Stromal Cells Through Targeting Ptn.
    2. Data indicate that myomiR-206 modulates Hmgb3 expression during myogenesis.
      Title: Hmgb3 is regulated by microRNA-206 during muscle regeneration.
    3. Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition.
      Title: Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition.
    4. Hmgb3 deficiency leads to a failure of hematopoietic stem cells to expand into normal numbers of lymphoid progenitor and myeloid progenitors
      Title: Hmgb3 deficiency deregulates proliferation and differentiation of common lymphoid and myeloid progenitors.
    5. Hmgb3 is required for the proper balance between hematopoietic stem cell self-renewal and differentiation.
      Title: Hmgb3 regulates the balance between hematopoietic stem cell self-renewal and differentiation.
    6. Overexpression of the HMGA2 gene in transgenic mice leads to the onset of mixed growth hormone/prolactin cell pituitary adenomas.
      Title: Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding, bending ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables four-way junction DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA geometric change ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of B cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of myeloid cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    high mobility group protein B3
    Names
    high mobility group protein 2a
    high mobility group protein 4
    high mobilty group protein 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293623.2 → NP_001280552.1  high mobility group protein B3 isoform 1

      See identical proteins and their annotated locations for NP_001280552.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AL833776
      Consensus CDS
      CCDS30180.1
      UniProtKB/Swiss-Prot
      O54879
      UniProtKB/TrEMBL
      Q544R9
      Related
      ENSMUSP00000086260.4, ENSMUST00000088874.10
      Conserved Domains (2) summary
      pfam00505
      Location:93 → 160
      HMG_box; HMG (high mobility group) box
      pfam09011
      Location:13 → 78
      HMG_box_2; HMG-box domain

    2. NM_001293624.2 → NP_001280553.1  high mobility group protein B3 isoform 1

      See identical proteins and their annotated locations for NP_001280553.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AL833776
      Consensus CDS
      CCDS30180.1
      UniProtKB/Swiss-Prot
      O54879
      UniProtKB/TrEMBL
      Q544R9
      Related
      ENSMUSP00000110232.3, ENSMUST00000072699.13
      Conserved Domains (2) summary
      pfam00505
      Location:93 → 160
      HMG_box; HMG (high mobility group) box
      pfam09011
      Location:13 → 78
      HMG_box_2; HMG-box domain

    3. NM_001293625.2 → NP_001280554.1  high mobility group protein B3 isoform 1

      See identical proteins and their annotated locations for NP_001280554.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AL833776
      Consensus CDS
      CCDS30180.1
      UniProtKB/Swiss-Prot
      O54879
      UniProtKB/TrEMBL
      Q544R9
      Related
      ENSMUSP00000015361.5, ENSMUST00000015361.11
      Conserved Domains (2) summary
      pfam00505
      Location:93 → 160
      HMG_box; HMG (high mobility group) box
      pfam09011
      Location:13 → 78
      HMG_box_2; HMG-box domain

    4. NM_001411295.1 → NP_001398224.1  high mobility group protein B3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL833776
      UniProtKB/Swiss-Prot
      O54879
      UniProtKB/TrEMBL
      Q544R9

    5. NM_001411296.1 → NP_001398225.1  high mobility group protein B3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL833776
      UniProtKB/Swiss-Prot
      O54879
      UniProtKB/TrEMBL
      Q544R9

    6. NM_001411299.1 → NP_001398228.1  high mobility group protein B3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL833776
      UniProtKB/Swiss-Prot
      O54879
      UniProtKB/TrEMBL
      Q544R9

    7. NM_001411300.1 → NP_001398229.1  high mobility group protein B3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL833776

    8. NM_001411301.1 → NP_001398230.1  high mobility group protein B3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL833776

    9. NM_001411302.1 → NP_001398231.1  high mobility group protein B3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL833776

    10. NM_001411303.1 → NP_001398232.1  high mobility group protein B3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL833776

    11. NM_008253.5 → NP_032279.1  high mobility group protein B3 isoform 1

      See identical proteins and their annotated locations for NP_032279.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AL833776
      Consensus CDS
      CCDS30180.1
      UniProtKB/Swiss-Prot
      O54879
      UniProtKB/TrEMBL
      Q544R9
      Related
      ENSMUSP00000110229.3, ENSMUST00000114582.9
      Conserved Domains (2) summary
      pfam00505
      Location:93 → 160
      HMG_box; HMG (high mobility group) box
      pfam09011
      Location:13 → 78
      HMG_box_2; HMG-box domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      70599523..70604261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527842.5 → XP_006527905.1  high mobility group protein B3 isoform X1

      See identical proteins and their annotated locations for XP_006527905.1

      UniProtKB/Swiss-Prot
      O54879
      UniProtKB/TrEMBL
      Q544R9
      Conserved Domains (2) summary
      pfam00505
      Location:93 → 160
      HMG_box; HMG (high mobility group) box
      pfam09011
      Location:13 → 78
      HMG_box_2; HMG-box domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54879.3 GenPept UniProtKB/Swiss-Prot:O54879

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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