Ccnd3 cyclin D3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccnd3provided by MGI
Official Full Name: cyclin D3provided by MGI
Primary source: MGI:MGI:88315
See related: Ensembl:ENSMUSG00000034165 AllianceGenome:MGI:88315
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9230106B05Rik
Summary: Enables cyclin-dependent protein serine/threonine kinase activity and protein kinase binding activity. Acts upstream of or within several processes, including T cell proliferation; negative regulation of transcription by RNA polymerase II; and regulation of cell population proliferation. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; extraembryonic component; eye; and gonad. Orthologous to human CCND3 (cyclin D3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in thymus adult (RPKM 402.8), adrenal adult (RPKM 319.1) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 23.37 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (47815976..47910614)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (47505051..47599689)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Cyclin D3 Protein Enforces Monogenic TCRbeta Expression by Mediating TCRbeta Protein-Signaled Feedback Inhibition of Vbeta Recombination.
Title: The Cyclin D3 Protein Enforces Monogenic TCRβ Expression by Mediating TCRβ Protein-Signaled Feedback Inhibition of Vβ Recombination.
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation.
Title: IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation.
Cyclin D3 deficiency promotes a slower, more oxidative skeletal muscle phenotype and ameliorates pathophysiology in the mdx mouse model of Duchenne muscular dystrophy.
Title: Cyclin D3 deficiency promotes a slower, more oxidative skeletal muscle phenotype and ameliorates pathophysiology in the mdx mouse model of Duchenne muscular dystrophy.
Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells.
Title: Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells.
Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells.
Title: Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells.
cyclin D3 regulates muscle fiber type phenotype.
Title: Lack of cyclin D3 induces skeletal muscle fiber-type shifting, increased endurance performance and hypermetabolism.
Cyclin D1 is indispensable for normal hematopoiesis; in its absence, cyclins D2 and D3 are also not expressed, preventing hematopoietic cell division and differentiation at its earliest stage. The results demonstrate that not all functions of individual D cyclins are redundant, and highlight a master role of cyclin D1 in hematopoiesis.
Title: The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells.
These results suggest that progesterone receptor overexpression in endometrial stromal cells, likely due to high progesterone levels, triggers cyclin D3 and Hoxa-10 overexpression, which may be involved in the pathological mechanisms of the mouse uterine decidual reaction.
Title: Hoxa-10 and Cyclin D3 Overexpression in the Decidual Reaction in a Superovulation Protocol in Young Adult C57BL/6J Mice.
the activation of TLR7 increased CCND3 expression via the downregulation of miR-15b in B cells.
Title: Activation of TLR7 increases CCND3 expression via the downregulation of miR-15b in B cells of systemic lupus erythematosus.
immature B and T cells use lymphocyte lineage- and developmental stage-specific mechanisms to inhibit Cyclin D3 protein levels.
Title: Lymphocyte lineage-specific and developmental stage specific mechanisms suppress cyclin D3 expression in response to DNA double strand breaks.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW146355 (e-PCR)
- UniSTS:181034

D17Mit65 (e-PCR), detects polymorphism
- UniSTS:128097

D17Dcr11 (e-PCR), detects polymorphism
- UniSTS:507514

RH124354 (e-PCR)
- UniSTS:161176

D17Mit115 (e-PCR), detects polymorphism
- UniSTS:116655

RH125472 (e-PCR)
- UniSTS:162291

D17Mit68 (e-PCR), detects polymorphism
- UniSTS:116469

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in hyaluronan biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to peptide hormone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin D3-CDK4 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin D3-CDK6 complex	IEA Inferred from Electronic Annotation more info
part_of cyclin D3-CDK6 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: G1/S-specific cyclin-D3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081635.1 → NP_001075104.1 G1/S-specific cyclin-D3

See identical proteins and their annotated locations for NP_001075104.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, compared to variant 3. Variant 2 encodes the same protein as variant 3.

Source sequence(s)

AK159503, AK161758, AK210362, BQ033424, BY146822, M86183

Consensus CDS

CCDS28850.1

UniProtKB/Swiss-Prot

P30282, Q62391, Q99KP2

UniProtKB/TrEMBL

Q3TSW4, Q3TWY0

Related

ENSMUSP00000040488.10, ENSMUST00000037333.17

Conserved Domains (1) summary

cl40454
Location:2 → 151

CYCLIN_SF; Cyclin box fold superfamily
NM_001081636.1 → NP_001075105.1 G1/S-specific cyclin-D3

See identical proteins and their annotated locations for NP_001075105.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

AK159503, AK161758, AK210362, BQ033424, BY146822, M86183

Consensus CDS

CCDS28850.1

UniProtKB/Swiss-Prot

P30282, Q62391, Q99KP2

UniProtKB/TrEMBL

Q3TSW4, Q3TWY0

Related

ENSMUSP00000126141.2, ENSMUST00000171031.8

Conserved Domains (1) summary

cl40454
Location:2 → 151

CYCLIN_SF; Cyclin box fold superfamily
NM_007632.2 → NP_031658.1 G1/S-specific cyclin-D3

See identical proteins and their annotated locations for NP_031658.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variant 1 encodes the same protein as variant 3.

Source sequence(s)

AK159503, AK210362, BQ033424, BY142612, M86183

Consensus CDS

CCDS28850.1

UniProtKB/Swiss-Prot

P30282, Q62391, Q99KP2

UniProtKB/TrEMBL

Q3TSW4, Q3TWY0

Related

ENSMUSP00000138091.2, ENSMUST00000182209.8

Conserved Domains (1) summary

cl40454
Location:2 → 151

CYCLIN_SF; Cyclin box fold superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

47815976..47910614

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523552.2 → XP_006523615.1 G1/S-specific cyclin-D3 isoform X1

Conserved Domains (1) summary

cl40454
Location:92 → 196

CYCLIN_SF; Cyclin box fold superfamily
XM_011246262.1 → XP_011244564.1 G1/S-specific cyclin-D3 isoform X3

See identical proteins and their annotated locations for XP_011244564.1

Conserved Domains (2) summary

pfam00134
Location:19 → 105

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:107 → 203

Cyclin_C; Cyclin, C-terminal domain
XM_006523553.5 → XP_006523616.1 G1/S-specific cyclin-D3 isoform X2

UniProtKB/TrEMBL

S4R216

Related

ENSMUSP00000138458.2, ENSMUST00000182539.8

Conserved Domains (1) summary

pfam02984
Location:1 → 55

Cyclin_C; Cyclin, C-terminal domain