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    ZHX2 zinc fingers and homeoboxes 2 [ Homo sapiens (human) ]

    Gene ID: 22882, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZHX2provided by HGNC
    Official Full Name
    zinc fingers and homeoboxes 2provided by HGNC
    Primary source
    HGNC:HGNC:18513
    See related
    Ensembl:ENSG00000178764 MIM:609185; AllianceGenome:HGNC:18513
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAF; AFR1
    Summary
    The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 12.8), lymph node (RPKM 11.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZHX2 in Genome Data Viewer
    Location:
    8q24.13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (122780379..122974510)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (123911550..124105660)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (123792618..123986750)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27852 Neighboring gene Sharpr-MPRA regulatory region 2746 Neighboring gene hESC enhancers GRCh37_chr8:123770608-123771162 and GRCh37_chr8:123771163-123771718 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:123792337-123792838 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:123792839-123793338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19487 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27853 Neighboring gene NANOG hESC enhancer GRCh37_chr8:123795211-123795745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27854 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:123799669-123800426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27856 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19489 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27857 Neighboring gene ZHX2 antisense RNA 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:123809400-123810599 Neighboring gene cyclin dependent kinase 5 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:123814233-123815192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:123815193-123816150 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:123817802-123819001 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:123848010-123849209 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:123849857-123850688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:123869217-123869717 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:123874507-123875706 Neighboring gene uncharacterized LOC124902011 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:123927788-123928344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27862 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27861 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:123960147-123960646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27864 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19492 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:124000413-124001612 Neighboring gene uncharacterized LOC124902013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27866 Neighboring gene derlin 1 Neighboring gene RNY4 pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (13 hits/1278 screens)

    EBI GWAS Catalog

    Description
    A genome-wide association study of behavioral disinhibition.
    EBI GWAS Catalog
    Genome-wide association study of antibody response to smallpox vaccine.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.
    EBI GWAS Catalog

    Interactions

    General gene information

    Clone Names

    • KIAA0854

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in chromatin  
    located_in cytosol  
    located_in nucleoplasm  
    is_active_in nucleus  
    is_active_in nucleus PubMed 
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    zinc fingers and homeoboxes protein 2
    Names
    AFP regulator 1
    alpha-fetoprotein regulator 1
    regulator of AFP
    transcription factor ZHX2
    zinc finger and homeodomain protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046951.1 RefSeqGene

      Range
      5307..198162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001362797.2 → NP_001349726.1  zinc fingers and homeoboxes protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316, BC042145, BM148156, HY099683
      Consensus CDS
      CCDS6336.1
      UniProtKB/Swiss-Prot
      Q9Y6X8
      Conserved Domains (2) summary
      smart00389
      Location:537 → 582
      HOX; Homeodomain
      cd00086
      Location:444 → 496
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    2. NM_001412796.1 → NP_001399725.1  zinc fingers and homeoboxes protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316
      UniProtKB/Swiss-Prot
      Q9Y6X8
    3. NM_001412797.1 → NP_001399726.1  zinc fingers and homeoboxes protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316
      UniProtKB/Swiss-Prot
      Q9Y6X8
    4. NM_001412798.1 → NP_001399727.1  zinc fingers and homeoboxes protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316
      UniProtKB/Swiss-Prot
      Q9Y6X8
    5. NM_001412799.1 → NP_001399728.1  zinc fingers and homeoboxes protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316
      UniProtKB/Swiss-Prot
      Q9Y6X8
    6. NM_001412800.1 → NP_001399729.1  zinc fingers and homeoboxes protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316
      UniProtKB/Swiss-Prot
      Q9Y6X8
    7. NM_001412801.1 → NP_001399730.1  zinc fingers and homeoboxes protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316
      UniProtKB/Swiss-Prot
      Q9Y6X8
    8. NM_001412802.1 → NP_001399731.1  zinc fingers and homeoboxes protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316
      UniProtKB/Swiss-Prot
      Q9Y6X8
    9. NM_001412803.1 → NP_001399732.1  zinc fingers and homeoboxes protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316
      UniProtKB/Swiss-Prot
      Q9Y6X8
    10. NM_001412804.1 → NP_001399733.1  zinc fingers and homeoboxes protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316
      UniProtKB/Swiss-Prot
      Q9Y6X8
    11. NM_001412805.1 → NP_001399734.1  zinc fingers and homeoboxes protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316
      UniProtKB/Swiss-Prot
      Q9Y6X8
    12. NM_001412806.1 → NP_001399735.1  zinc fingers and homeoboxes protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316
      UniProtKB/Swiss-Prot
      Q9Y6X8
    13. NM_001412807.1 → NP_001399736.1  zinc fingers and homeoboxes protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316
      UniProtKB/Swiss-Prot
      Q9Y6X8
    14. NM_001412808.1 → NP_001399737.1  zinc fingers and homeoboxes protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316
      UniProtKB/Swiss-Prot
      Q9Y6X8
    15. NM_001412809.1 → NP_001399738.1  zinc fingers and homeoboxes protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316
      UniProtKB/Swiss-Prot
      Q9Y6X8
    16. NM_001412810.1 → NP_001399739.1  zinc fingers and homeoboxes protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316
      UniProtKB/Swiss-Prot
      Q9Y6X8
    17. NM_001412811.1 → NP_001399740.1  zinc fingers and homeoboxes protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316
      UniProtKB/Swiss-Prot
      Q9Y6X8
    18. NM_001412812.1 → NP_001399741.1  zinc fingers and homeoboxes protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316
      UniProtKB/Swiss-Prot
      Q9Y6X8
    19. NM_001412813.1 → NP_001399742.1  zinc fingers and homeoboxes protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316
    20. NM_014943.5 → NP_055758.1  zinc fingers and homeoboxes protein 2 isoform 1

      See identical proteins and their annotated locations for NP_055758.1

      Status: REVIEWED

      Source sequence(s)
      AC104316, BC042145, BM148156, HY099683
      Consensus CDS
      CCDS6336.1
      UniProtKB/Swiss-Prot
      Q9Y6X8
      Related
      ENSP00000314709.4, ENST00000314393.6
      Conserved Domains (2) summary
      smart00389
      Location:537 → 582
      HOX; Homeodomain
      cd00086
      Location:444 → 496
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RNA

    1. NR_182048.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016405, AC104316

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      122780379..122974510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421590.1 → XP_047277546.1  zinc fingers and homeoboxes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y6X8
    2. XM_011516932.4 → XP_011515234.1  zinc fingers and homeoboxes protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011515234.1

      UniProtKB/Swiss-Prot
      Q9Y6X8
      Conserved Domains (2) summary
      smart00389
      Location:537 → 582
      HOX; Homeodomain
      cd00086
      Location:444 → 496
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    3. XM_005250836.6 → XP_005250893.1  zinc fingers and homeoboxes protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005250893.1

      UniProtKB/Swiss-Prot
      Q9Y6X8
      Conserved Domains (2) summary
      smart00389
      Location:537 → 582
      HOX; Homeodomain
      cd00086
      Location:444 → 496
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    4. XM_047421589.1 → XP_047277545.1  zinc fingers and homeoboxes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y6X8
    5. XM_047421588.1 → XP_047277544.1  zinc fingers and homeoboxes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y6X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      123911550..124105660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360145.1 → XP_054216120.1  zinc fingers and homeoboxes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y6X8
    2. XM_054360144.1 → XP_054216119.1  zinc fingers and homeoboxes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y6X8
    3. XM_054360142.1 → XP_054216117.1  zinc fingers and homeoboxes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y6X8
    4. XM_054360141.1 → XP_054216116.1  zinc fingers and homeoboxes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y6X8
    5. XM_054360143.1 → XP_054216118.1  zinc fingers and homeoboxes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y6X8
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