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    FOXM1 forkhead box M1 [ Homo sapiens (human) ]

    Gene ID: 2305, updated on 9-Dec-2024

    Summary

    Official Symbol
    FOXM1provided by HGNC
    Official Full Name
    forkhead box M1provided by HGNC
    Primary source
    HGNC:HGNC:3818
    See related
    Ensembl:ENSG00000111206 MIM:602341; AllianceGenome:HGNC:3818
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MPP2; HFH11; HNF-3; INS-1; MPP-2; PIG29; FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11; TRIDENT; MPHOSPH2
    Summary
    The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
    Expression
    Broad expression in testis (RPKM 16.1), bone marrow (RPKM 11.2) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FOXM1 in Genome Data Viewer
    Location:
    12p13.33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (2857680..2877174, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (2863691..2883185, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (2966846..2986340, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8339 Neighboring gene integrin alpha FG-GAP repeat containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2943338-2943882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2943883-2944427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2944428-2944971 Neighboring gene nuclear receptor interacting protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2953993-2954980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2954981-2955966 Neighboring gene testis expressed 52 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4135 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2988229-2989182 Neighboring gene uncharacterized LOC124902860 Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4136 Neighboring gene TUB like protein 3 Neighboring gene Sharpr-MPRA regulatory region 7040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:3032139-3032645 Neighboring gene U7 small nuclear RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of stress-activated MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell population proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    forkhead box protein M1
    Names
    Forkhead, drosophila, homolog-like 16
    HNF-3/fork-head homolog 11
    M-phase phosphoprotein 2
    MPM-2 reactive phosphoprotein 2
    forkhead box M1-D
    forkhead-related protein FKHL16
    hepatocyte nuclear factor 3 forkhead homolog 11
    transcription factor Trident
    winged-helix factor from INS-1 cells

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029590.2 RefSeqGene

      Range
      4982..24476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001243088.2 → NP_001230017.1  forkhead box protein M1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses two alternate in-frame splice junctions compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC005841, AC005911
      Consensus CDS
      CCDS76506.1
      UniProtKB/TrEMBL
      A0A0D9SFF0
      Related
      ENSP00000486536.1, ENST00000627656.2
      Conserved Domains (1) summary
      cd00059
      Location:235 → 310
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    2. NM_001243089.2 → NP_001230018.1  forkhead box protein M1 isoform 5

      See identical proteins and their annotated locations for NP_001230018.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame exons and uses an alternate in-frame splice site compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC005841, AC005911
      UniProtKB/TrEMBL
      A8K591
      Conserved Domains (1) summary
      cd00059
      Location:235 → 310
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    3. NM_001413925.1 → NP_001400854.1  forkhead box protein M1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
    4. NM_001413926.1 → NP_001400855.1  forkhead box protein M1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
    5. NM_001413927.1 → NP_001400856.1  forkhead box protein M1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
      UniProtKB/TrEMBL
      A0A2P9DTZ0
    6. NM_001413928.1 → NP_001400857.1  forkhead box protein M1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
    7. NM_001413929.1 → NP_001400858.1  forkhead box protein M1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
    8. NM_001413930.1 → NP_001400859.1  forkhead box protein M1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
    9. NM_001413931.1 → NP_001400860.1  forkhead box protein M1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
    10. NM_001413932.1 → NP_001400861.1  forkhead box protein M1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
    11. NM_001413933.1 → NP_001400862.1  forkhead box protein M1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
    12. NM_001413934.1 → NP_001400863.1  forkhead box protein M1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
    13. NM_001413935.1 → NP_001400864.1  forkhead box protein M1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
    14. NM_001413936.1 → NP_001400865.1  forkhead box protein M1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
    15. NM_001413937.1 → NP_001400866.1  forkhead box protein M1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
    16. NM_001413938.1 → NP_001400867.1  forkhead box protein M1 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
    17. NM_001413939.1 → NP_001400868.1  forkhead box protein M1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
    18. NM_001413940.1 → NP_001400869.1  forkhead box protein M1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
    19. NM_001413941.1 → NP_001400870.1  forkhead box protein M1 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
    20. NM_001413942.1 → NP_001400871.1  forkhead box protein M1 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
    21. NM_001413943.1 → NP_001400872.1  forkhead box protein M1 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC005841, AC005911
    22. NM_021953.4 → NP_068772.2  forkhead box protein M1 isoform 2

      See identical proteins and their annotated locations for NP_068772.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC005841, AC005911
      Consensus CDS
      CCDS8515.1
      UniProtKB/Swiss-Prot
      O43258, O43259, O43260, Q08050, Q4ZGG7, Q9BRL2
      UniProtKB/TrEMBL
      Q53Y49
      Related
      ENSP00000352901.4, ENST00000359843.8
      Conserved Domains (2) summary
      cd00059
      Location:236 → 311
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      cl28033
      Location:402 → 711
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    23. NM_202002.3 → NP_973731.1  forkhead box protein M1 isoform 1

      See identical proteins and their annotated locations for NP_973731.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC005841, AC005911
      Consensus CDS
      CCDS8516.1
      UniProtKB/TrEMBL
      A0A2P9DTZ8
      Related
      ENSP00000342307.2, ENST00000342628.6
      Conserved Domains (2) summary
      cd00059
      Location:236 → 311
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      cl28033
      Location:504 → 749
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    24. NM_202003.3 → NP_973732.1  forkhead box protein M1 isoform 3

      See identical proteins and their annotated locations for NP_973732.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC005841, AC005911
      Consensus CDS
      CCDS8517.1
      UniProtKB/TrEMBL
      A0A2P9DTZ1
      Related
      ENSP00000354492.3, ENST00000361953.7
      Conserved Domains (1) summary
      cd00059
      Location:236 → 311
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      2857680..2877174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428550.1 → XP_047284506.1  forkhead box protein M1 isoform X4

    2. XM_047428547.1 → XP_047284503.1  forkhead box protein M1 isoform X2

    3. XM_047428549.1 → XP_047284505.1  forkhead box protein M1 isoform X3

    4. XM_011520932.2 → XP_011519234.1  forkhead box protein M1 isoform X1

      Conserved Domains (1) summary
      cd00059
      Location:236 → 311
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

    RNA

    1. XR_931507.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      2863691..2883185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371481.1 → XP_054227456.1  forkhead box protein M1 isoform X4

    2. XM_054371479.1 → XP_054227454.1  forkhead box protein M1 isoform X2

    3. XM_054371480.1 → XP_054227455.1  forkhead box protein M1 isoform X3

    4. XM_054371478.1 → XP_054227453.1  forkhead box protein M1 isoform X1

    RNA

    1. XR_008488550.1 RNA Sequence