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    Pdrg1 p53 and DNA damage regulated 1 [ Mus musculus (house mouse) ]

    Gene ID: 68559, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pdrg1provided by MGI
    Official Full Name
    p53 and DNA damage regulated 1provided by MGI
    Primary source
    MGI:MGI:1915809
    See related
    Ensembl:ENSMUSG00000027472 AllianceGenome:MGI:1915809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pdrg; 1110004D19Rik
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in cytoplasm. Predicted to be part of RPAP3/R2TP/prefoldin-like complex. Orthologous to human PDRG1 (p53 and DNA damage regulated 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 53.3), heart adult (RPKM 47.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pdrg1 in Genome Data Viewer
    Location:
    2 H1; 2 75.41 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152850810..152857939, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (153008890..153016019, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06085 Neighboring gene dual specificity phosphatase-like 15 Neighboring gene tubulin tyrosine ligase-like family, member 9 Neighboring gene STARR-seq mESC enhancer starr_06086 Neighboring gene predicted gene 14199 Neighboring gene STARR-positive B cell enhancer mm9_chr2:152840956-152841257 Neighboring gene X-linked Kx blood group related 7 Neighboring gene predicted gene, 32286 Neighboring gene cerebral cavernous malformation 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation. Luo X, et al. Oncogene, 2003 Oct 16. PMID 14562055
    2. Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size. Lin L, et al. Neuron, 2024 Jul 3. PMID 38697111,
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation
      Title: Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RPAP3/R2TP/prefoldin-like complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RPAP3/R2TP/prefoldin-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of prefoldin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    p53 and DNA damage-regulated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418641.1 → NP_001405570.1  p53 and DNA damage-regulated protein 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL928862

    2. NM_001418642.1 → NP_001405571.1  p53 and DNA damage-regulated protein 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL928862

    3. NM_001418643.1 → NP_001405572.1  p53 and DNA damage-regulated protein 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL928862

    4. NM_001418644.1 → NP_001405573.1  p53 and DNA damage-regulated protein 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL928862

    5. NM_001418645.1 → NP_001405574.1  p53 and DNA damage-regulated protein 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL928862

    6. NM_001418646.1 → NP_001405575.1  p53 and DNA damage-regulated protein 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL928862

    7. NM_178939.3 → NP_849270.1  p53 and DNA damage-regulated protein 1 isoform a

      See identical proteins and their annotated locations for NP_849270.1

      Status: VALIDATED

      Source sequence(s)
      AL928862
      Consensus CDS
      CCDS16904.1
      UniProtKB/Swiss-Prot
      P59048
      UniProtKB/TrEMBL
      Q3UKN2
      Related
      ENSMUSP00000028972.9, ENSMUST00000028972.9
      Conserved Domains (1) summary
      cl09111
      Location:27 → 108
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      152850810..152857939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252038.1 → XP_030107898.1  p53 and DNA damage-regulated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P59048
      UniProtKB/TrEMBL
      Q3UKN2
      Conserved Domains (1) summary
      cl09111
      Location:27 → 108
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59048.1 GenPept UniProtKB/Swiss-Prot:P59048

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