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    Lrrc3b leucine rich repeat containing 3B [ Mus musculus (house mouse) ]

    Gene ID: 218763, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lrrc3bprovided by MGI
    Official Full Name
    leucine rich repeat containing 3Bprovided by MGI
    Primary source
    MGI:MGI:2384996
    See related
    Ensembl:ENSMUSG00000045201 AllianceGenome:MGI:2384996
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LRP15
    Summary
    Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human LRRC3B (leucine rich repeat containing 3B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart adult (RPKM 9.9), cerebellum adult (RPKM 6.9) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc3b in Genome Data Viewer
    Location:
    14 A1; 14 7.08 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (7030776..7112248)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (15357515..15438987, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36012 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:16602478-16602631 Neighboring gene predicted gene, 31804 Neighboring gene STARR-seq mESC enhancer starr_36010 Neighboring gene STARR-seq mESC enhancer starr_36009 Neighboring gene STARR-seq mESC enhancer starr_36008 Neighboring gene STARR-seq mESC enhancer starr_36007 Neighboring gene STARR-seq mESC enhancer starr_36006 Neighboring gene RIKEN cDNA B230110C06 gene Neighboring gene STARR-seq mESC enhancer starr_36005 Neighboring gene STARR-seq mESC enhancer starr_36004 Neighboring gene predicted gene, 31658 Neighboring gene predicted gene, 31577 Neighboring gene STARR-seq mESC enhancer starr_36003 Neighboring gene STARR-seq mESC enhancer starr_36002 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:15916488-15916671 Neighboring gene predicted gene, 31517

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Odor-evoked gene regulation and visualization in olfactory receptor neurons. Bennett MK, et al. Mol Cell Neurosci, 2010 Apr. PMID 20080187, Free PMC Article
    2. Activity-dependent genes in mouse olfactory sensory neurons. Fischl AM, et al. Chem Senses, 2014 Jun. PMID 24692514, Free PMC Article
    3. PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Yoshida Y, et al. Neuron, 2006 Dec 7. PMID 17145500, Free PMC Article
    4. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
    5. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC30505

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 3B
    Names
    leucine-rich repeat protein 15
    leucine-rich repeat protein LRP15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425741.1 → NP_001412670.1  leucine-rich repeat-containing protein 3B precursor

      Status: VALIDATED

      Source sequence(s)
      AC117656, AC158537
      UniProtKB/Swiss-Prot
      Q8VCH9
      UniProtKB/TrEMBL
      Q543Z7

    2. NM_001425742.1 → NP_001412671.1  leucine-rich repeat-containing protein 3B precursor

      Status: VALIDATED

      Source sequence(s)
      AC117656, AC158537
      UniProtKB/Swiss-Prot
      Q8VCH9
      UniProtKB/TrEMBL
      Q543Z7

    3. NM_146052.5 → NP_666164.1  leucine-rich repeat-containing protein 3B precursor

      See identical proteins and their annotated locations for NP_666164.1

      Status: VALIDATED

      Source sequence(s)
      AC117656, AC158537
      Consensus CDS
      CCDS26829.1
      UniProtKB/Swiss-Prot
      Q8VCH9
      UniProtKB/TrEMBL
      Q543Z7
      Related
      ENSMUSP00000059463.5, ENSMUST00000055211.6
      Conserved Domains (3) summary
      smart00013
      Location:33 → 68
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:66 → 89
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:69 → 125
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      7030776..7112248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518006.3 → XP_006518069.1  leucine-rich repeat-containing protein 3B isoform X1

      See identical proteins and their annotated locations for XP_006518069.1

      UniProtKB/Swiss-Prot
      Q8VCH9
      UniProtKB/TrEMBL
      Q543Z7
      Related
      ENSMUSP00000153616.2, ENSMUST00000223700.2
      Conserved Domains (3) summary
      smart00013
      Location:33 → 68
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:66 → 89
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:69 → 125
      LRR_8; Leucine rich repeat

    2. XM_006518005.3 → XP_006518068.1  leucine-rich repeat-containing protein 3B isoform X1

      See identical proteins and their annotated locations for XP_006518068.1

      UniProtKB/Swiss-Prot
      Q8VCH9
      UniProtKB/TrEMBL
      Q543Z7
      Related
      ENSMUSP00000128624.2, ENSMUST00000163937.3
      Conserved Domains (3) summary
      smart00013
      Location:33 → 68
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:66 → 89
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:69 → 125
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCH9.1 GenPept UniProtKB/Swiss-Prot:Q8VCH9

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