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    ILF3 interleukin enhancer binding factor 3 [ Homo sapiens (human) ]

    Gene ID: 3609, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ILF3provided by HGNC
    Official Full Name
    interleukin enhancer binding factor 3provided by HGNC
    Primary source
    HGNC:HGNC:6038
    See related
    Ensembl:ENSG00000129351 MIM:603182; AllianceGenome:HGNC:6038
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CBTF; DRBF; MMP4; MPP4; NF90; NFAR; NF110; NF90a; NF90b; NF90c; NFAR2; TCP80; DRBP76; NF110b; NFAR-1; NFAR-2; NFAR90; TCP110; MPP4110; NF90ctv; NFAR110; MPHOSPH4; NF-AT-90
    Summary
    This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]
    Expression
    Ubiquitous expression in bone marrow (RPKM 45.0), testis (RPKM 34.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ILF3 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10654346..10692400)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10780831..10818864)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10765022..10803076)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10085 Neighboring gene solute carrier family 44 member 2 (CTL2 blood group) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10734687-10735268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10747236-10747758 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10763030-10763532 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10763533-10764034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13983 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10087 Neighboring gene ILF3 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10801737-10802532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10802533-10803326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10806023-10806522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10811832-10812580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13985 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10826293-10826482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10090 Neighboring gene queuine tRNA-ribosyltransferase catalytic subunit 1 Neighboring gene microRNA 638 Neighboring gene dynamin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. NF90 binds the dengue virus RNA 3' terminus and is a positive regulator of dengue virus replication. Gomila RC, et al. PLoS One, 2011 Feb 28. PMID 21386893, Free PMC Article
    2. Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection. Li X, et al. Mol Cell, 2017 Jul 20. PMID 28625552
    3. Mapping interleukin enhancer binding factor 3 gene (ILF3) to human chromosome 19 (19q11-qter and 19p11-p13.1) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates. Marcoulatos P, et al. J Interferon Cytokine Res, 1998 May. PMID 9620363
    4. Nuclear factor 90 negatively regulates influenza virus replication by interacting with viral nucleoprotein. Wang P, et al. J Virol, 2009 Aug. PMID 19494010, Free PMC Article
    5. Coordinated Action of Two Double-Stranded RNA Binding Motifs and an RGG Motif Enables Nuclear Factor 90 To Flexibly Target Different RNA Substrates. Schmidt T, et al. Biochemistry, 2016 Feb 16. PMID 26795062

    See all (421) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deficiency of smooth muscle cell ILF3 alleviates intimal hyperplasia via HMGB1 mRNA degradation-mediated regulation of the STAT3/DUSP16 axis.
      Title: Deficiency of smooth muscle cell ILF3 alleviates intimal hyperplasia via HMGB1 mRNA degradation-mediated regulation of the STAT3/DUSP16 axis.
    2. Role of ATF3 triggering M2 macrophage polarization to protect against the inflammatory injury of sepsis through ILF3/NEAT1 axis.
      Title: Role of ATF3 triggering M2 macrophage polarization to protect against the inflammatory injury of sepsis through ILF3/NEAT1 axis.
    3. Astragaloside IV promotes keratinocyte proliferation and migration through upregulating lncRNA H19 recruited ILF3 to enhance the stability of CDK4 mRNA.
      Title: Astragaloside IV promotes keratinocyte proliferation and migration through upregulating lncRNA H19 recruited ILF3 to enhance the stability of CDK4 mRNA.
    4. E2F1-mediated KDM4A-AS1 up-regulation promotes EMT of hepatocellular carcinoma cells by recruiting ILF3 to stabilize AURKA mRNA.
      Title: E2F1-mediated KDM4A-AS1 up-regulation promotes EMT of hepatocellular carcinoma cells by recruiting ILF3 to stabilize AURKA mRNA.
    5. PSMD3-ILF3 signaling cascade drives lung cancer cell proliferation and migration.
      Title: PSMD3-ILF3 signaling cascade drives lung cancer cell proliferation and migration.
    6. Genome-wide CRISPR screens identify ILF3 as a mediator of mTORC1-dependent amino acid sensing.
      Title: Genome-wide CRISPR screens identify ILF3 as a mediator of mTORC1-dependent amino acid sensing.
    7. Prognostic and immunotherapeutic predictive value of interleukin enhancer-binding factor 3 in hepatocellular carcinoma: Integrated bioinformatics and experimental analysis.
      Title: Prognostic and immunotherapeutic predictive value of interleukin enhancer-binding factor 3 in hepatocellular carcinoma: Integrated bioinformatics and experimental analysis.
    8. Hsa_circ_0005050 interacts with ILF3 and affects cell apoptosis and proliferation by disrupting the balance between p53 and p65.
      Title: Hsa_circ_0005050 interacts with ILF3 and affects cell apoptosis and proliferation by disrupting the balance between p53 and p65.
    9. RNA binding protein POP7 regulates ILF3 mRNA stability and expression to promote breast cancer progression.
      Title: RNA binding protein POP7 regulates ILF3 mRNA stability and expression to promote breast cancer progression.
    10. NF90 interacts with components of RISC and modulates association of Ago2 with mRNA.
      Title: NF90 interacts with components of RISC and modulates association of Ago2 with mRNA.
    Submit: New GeneRIF Correction See all GeneRIFs (85)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify interleukin enhancer binding factor 3 (ILF3, NF90), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify interleukin enhancer binding factor 3 (ILF3, NF90), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify interleukin enhancer binding factor 3 (ILF3, NF90), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify interleukin enhancer binding factor 3 (ILF3, NF90), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, interleukin enhancer binding factor 3 (ILF3), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with ILF3 is increased by RRE PubMed
    rev NF90 inhibits HIV-1 Rev-dependent activity by interfering with the RNA export function of Rev PubMed
    rev NF90-RRE-RNA interaction alters HIV-1 Rev subcellular localization PubMed
    rev Three specific domains (residues 89-123, 405-593, and 594-670) of NF90 promote Rev-RRE mediated nuclear export of Gag mRNA, which is dependent on CRM1 function PubMed
    rev The C-terminal 67 amino acids (604-671) of NF90 interact with HIV-1 Rev PubMed
    Tat tat NF90ctv-TAR RNA interaction shows significant inhibition of Tat-transactivation of the HIV-1 LTR in cells expressing NF90ctv, as well as changes in histone H3 methylation of HIV chromatin PubMed
    tat The C-terminal variant of nuclear factor 90 (NF90ctv) with strong affinity for HIV-1 TAR RNA, competes with Tat/TAR interaction in vitro PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of interleukin enhancer binding factor 3 (ILF3, NF90) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    capsid gag Expression of NF90 drastically reduces the amount of p24 expression, suggesting inhibition of HIV-1 particle production PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding HDA PubMed 
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables virus receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of viral genome replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spliceosome-depend formation of circular RNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular region HDA PubMed 
    located_in membrane HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin enhancer-binding factor 3
    Names
    M phase phosphoprotein 4, nuclear factor associated with DS RNA
    M-phase phosphoprotein 4
    double-stranded RNA-binding protein, 76 kD
    dsRNA binding protein NFAR-2/MPP4
    interleukin enhancer binding factor 3, 90kD
    interleukin enhancer binding factor 3, 90kDa
    nuclear factor associated with dsRNA
    nuclear factor of activated T-cells 110 kDa
    nuclear factor of activated T-cells 90 kDa
    nuclear factor of activated T-cells, 90 kD
    translational control protein 80

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029220.1 RefSeqGene

      Range
      5086..43140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001137673.2 → NP_001131145.1  interleukin enhancer-binding factor 3 isoform e

      See identical proteins and their annotated locations for NP_001131145.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR and coding region compared to variant 4. The resulting isoform (e) has a distinct C-terminus compared to isoform d. Variants 5 and 19-21 all encode the same isoform (e).
      Source sequence(s)
      AC011475, AW576353, BC064836
      Consensus CDS
      CCDS45967.1
      UniProtKB/TrEMBL
      A8K590, F4ZW64
      Related
      ENSP00000384660.2, ENST00000407004.8
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:524 → 595
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    2. NM_001394808.1 → NP_001381737.1  interleukin enhancer-binding factor 3 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC011475
      Consensus CDS
      CCDS45965.1
      UniProtKB/TrEMBL
      F4ZW66
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:524 → 595
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    3. NM_001394809.1 → NP_001381738.1  interleukin enhancer-binding factor 3 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC011475
      Consensus CDS
      CCDS45965.1
      UniProtKB/TrEMBL
      F4ZW66
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:524 → 595
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    4. NM_001394810.1 → NP_001381739.1  interleukin enhancer-binding factor 3 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC011475
      Consensus CDS
      CCDS45965.1
      UniProtKB/TrEMBL
      F4ZW66
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:524 → 595
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    5. NM_001394811.1 → NP_001381740.1  interleukin enhancer-binding factor 3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC011475
      Consensus CDS
      CCDS12246.1
      UniProtKB/Swiss-Prot
      A8K6F2, G5E9M5, O43409, Q12906, Q6P1X1, Q86XY7, Q99544, Q99545, Q9BZH4, Q9BZH5, Q9NQ95, Q9NQ96, Q9NQ97, Q9NQ98, Q9NQ99, Q9NQA0, Q9NQA1, Q9NQA2, Q9NRN2, Q9NRN3, Q9NRN4, Q9UMZ9, Q9UN00, Q9UN84, Q9UNA2
      UniProtKB/TrEMBL
      F4ZW66
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:520 → 591
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    6. NM_001394812.1 → NP_001381741.1  interleukin enhancer-binding factor 3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC011475
      Consensus CDS
      CCDS12246.1
      UniProtKB/Swiss-Prot
      A8K6F2, G5E9M5, O43409, Q12906, Q6P1X1, Q86XY7, Q99544, Q99545, Q9BZH4, Q9BZH5, Q9NQ95, Q9NQ96, Q9NQ97, Q9NQ98, Q9NQ99, Q9NQA0, Q9NQA1, Q9NQA2, Q9NRN2, Q9NRN3, Q9NRN4, Q9UMZ9, Q9UN00, Q9UN84, Q9UNA2
      UniProtKB/TrEMBL
      F4ZW66
      Related
      ENSP00000468156.1, ENST00000590261.5
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:520 → 591
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    7. NM_001394813.1 → NP_001381742.1  interleukin enhancer-binding factor 3 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC011475
      UniProtKB/TrEMBL
      F4ZW66
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:524 → 595
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    8. NM_001394814.1 → NP_001381743.1  interleukin enhancer-binding factor 3 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC011475
      UniProtKB/TrEMBL
      F4ZW66
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:520 → 591
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    9. NM_001394815.1 → NP_001381744.1  interleukin enhancer-binding factor 3 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC011475
      UniProtKB/TrEMBL
      F4ZW65
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:524 → 595
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    10. NM_001394816.1 → NP_001381745.1  interleukin enhancer-binding factor 3 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC011475
      UniProtKB/TrEMBL
      F4ZW65
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:524 → 595
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    11. NM_001394817.1 → NP_001381746.1  interleukin enhancer-binding factor 3 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC011475
      UniProtKB/TrEMBL
      A8K590, F4ZW64
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:520 → 591
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    12. NM_001394818.1 → NP_001381747.1  interleukin enhancer-binding factor 3 isoform j

      Status: REVIEWED

      Source sequence(s)
      AC011475
      UniProtKB/TrEMBL
      A8K590, F4ZW64
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:524 → 595
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    13. NM_001394819.1 → NP_001381748.1  interleukin enhancer-binding factor 3 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC011475
      UniProtKB/TrEMBL
      A8K590, F4ZW64
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:520 → 591
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    14. NM_001394820.1 → NP_001381749.1  interleukin enhancer-binding factor 3 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC011475
      UniProtKB/TrEMBL
      A8K590, F4ZW64
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:520 → 591
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    15. NM_001394821.1 → NP_001381750.1  interleukin enhancer-binding factor 3 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC011475
      Consensus CDS
      CCDS45967.1
      UniProtKB/TrEMBL
      A8K590, F4ZW64
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:524 → 595
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    16. NM_001394822.1 → NP_001381751.1  interleukin enhancer-binding factor 3 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC011475
      Consensus CDS
      CCDS45967.1
      UniProtKB/TrEMBL
      A8K590, F4ZW64
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:524 → 595
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    17. NM_001394823.1 → NP_001381752.1  interleukin enhancer-binding factor 3 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC011475
      Consensus CDS
      CCDS45967.1
      UniProtKB/TrEMBL
      A8K590, F4ZW64
      Related
      ENSP00000465515.1, ENST00000592763.5
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:524 → 595
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    18. NM_001394824.1 → NP_001381753.1  interleukin enhancer-binding factor 3 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC011475
      Consensus CDS
      CCDS12247.1
      UniProtKB/TrEMBL
      A8K590, F4ZW64
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:520 → 591
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    19. NM_001394826.1 → NP_001381755.1  interleukin enhancer-binding factor 3 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC011475
      Consensus CDS
      CCDS12247.1
      UniProtKB/TrEMBL
      A8K590, F4ZW64
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:520 → 591
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    20. NM_001394827.1 → NP_001381756.1  interleukin enhancer-binding factor 3 isoform l

      Status: REVIEWED

      Source sequence(s)
      AC011475
      UniProtKB/TrEMBL
      A8K590, F4ZW64
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:524 → 595
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    21. NM_004516.4 → NP_004507.2  interleukin enhancer-binding factor 3 isoform b

      See identical proteins and their annotated locations for NP_004507.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 4. The resulting isoform (b) has a distinct C-terminus compared to isoform d. This isoform is also called NFAR-1 or DRBP76. Variants 2, 22, and 24 all encode the same isoform (b).
      Source sequence(s)
      AJ271745, AJ271747, DC320902, X98264
      Consensus CDS
      CCDS12247.1
      UniProtKB/TrEMBL
      A8K590, F4ZW64
      Related
      ENSP00000465219.1, ENST00000589998.6
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:520 → 591
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    22. NM_012218.4 → NP_036350.2  interleukin enhancer-binding factor 3 isoform a

      See identical proteins and their annotated locations for NP_036350.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate splice site in the 3' coding region compared to variant 4. The resulting isoform (a) has a shorter C-terminus compared to isoform d. This isoform is also called NFAR-2, ILF3-E and NF110. Variants 1, 9, and 10 all encode the same isoform (a).
      Source sequence(s)
      AF167570, AJ271747, DC320902, X98264
      Consensus CDS
      CCDS12246.1
      UniProtKB/Swiss-Prot
      A8K6F2, G5E9M5, O43409, Q12906, Q6P1X1, Q86XY7, Q99544, Q99545, Q9BZH4, Q9BZH5, Q9NQ95, Q9NQ96, Q9NQ97, Q9NQ98, Q9NQ99, Q9NQA0, Q9NQA1, Q9NQA2, Q9NRN2, Q9NRN3, Q9NRN4, Q9UMZ9, Q9UN00, Q9UN84, Q9UNA2
      UniProtKB/TrEMBL
      F4ZW66
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:520 → 591
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    23. NM_017620.3 → NP_060090.2  interleukin enhancer-binding factor 3 isoform d

      See identical proteins and their annotated locations for NP_060090.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (d). Variants 4 and 6-8 all encode the same isoform (d).
      Source sequence(s)
      AF167570, AJ271744, AJ271747, BC064836, DC320902
      Consensus CDS
      CCDS45965.1
      UniProtKB/TrEMBL
      F4ZW66
      Related
      ENSP00000468181.1, ENST00000588657.6
      Conserved Domains (3) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19910
      Location:399 → 470
      DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
      cd19912
      Location:524 → 595
      DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

    24. NM_153464.3 → NP_703194.1  interleukin enhancer-binding factor 3 isoform c

      See identical proteins and their annotated locations for NP_703194.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding region compared to variant 4. The resulting isoform (c) has a distinct C-terminus compared to isoform d. This isoform is also called DRBP76 delta and ILF3-C.
      Source sequence(s)
      AJ271745, AJ271746, AJ271747, DC320902, X98264
      Consensus CDS
      CCDS45966.1
      UniProtKB/TrEMBL
      A8K590, F4ZW64
      Related
      ENSP00000250241.8, ENST00000250241.12
      Conserved Domains (2) summary
      smart00572
      Location:88 → 342
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      smart00358
      Location:402 → 466
      DSRM; Double-stranded RNA binding motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      10654346..10692400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438779.1 → XP_047294735.1  interleukin enhancer-binding factor 3 isoform X1

      UniProtKB/TrEMBL
      F4ZW66

    2. XM_047438778.1 → XP_047294734.1  interleukin enhancer-binding factor 3 isoform X1

      UniProtKB/TrEMBL
      F4ZW66

    3. XM_047438780.1 → XP_047294736.1  interleukin enhancer-binding factor 3 isoform X2

    4. XM_047438781.1 → XP_047294737.1  interleukin enhancer-binding factor 3 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      10780831..10818864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320895.1 → XP_054176870.1  interleukin enhancer-binding factor 3 isoform X1

      UniProtKB/TrEMBL
      F4ZW66

    2. XM_054320894.1 → XP_054176869.1  interleukin enhancer-binding factor 3 isoform X1

      UniProtKB/TrEMBL
      F4ZW66

    3. XM_054320896.1 → XP_054176871.1  interleukin enhancer-binding factor 3 isoform X2

    4. XM_054320897.1 → XP_054176872.1  interleukin enhancer-binding factor 3 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001394825.1: Suppressed sequence

      Description
      NM_001394825.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12906.3 GenPept UniProtKB/Swiss-Prot:Q12906

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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