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    Apol9a apolipoprotein L 9a [ Mus musculus (house mouse) ]

    Gene ID: 223672, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Apol9aprovided by MGI
    Official Full Name
    apolipoprotein L 9aprovided by MGI
    Primary source
    MGI:MGI:3606001
    See related
    Ensembl:ENSMUSG00000057346 AllianceGenome:MGI:3606001
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable chloride channel activity and lipid binding activity. Predicted to be located in extracellular space. Predicted to be part of high-density lipoprotein particle and very-low-density lipoprotein particle. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human APOL1 (apolipoprotein L1) and APOL2 (apolipoprotein L2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 37.4), small intestine adult (RPKM 36.8) and 5 other tissues See more
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    Genomic context

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    See Apol9a in Genome Data Viewer
    Location:
    15 D3; 15 36.4 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (77287989..77295280, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (77403789..77411080, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3787 Neighboring gene predicted gene, 41353 Neighboring gene apolipoprotein L 7a Neighboring gene predicted gene, 36194 Neighboring gene apolipoprotein L 7b Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse Apolipoprotein L9 is a phosphatidylethanolamine-binding protein. Arvind TA, et al. Biochem Biophys Res Commun, 2016 Oct 28. PMID 27697524
    2. ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation. de Reuver R, et al. Cell Rep, 2021 Aug 10. PMID 34380029
    3. ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation. de Reuver R, et al. Nature, 2022 Jul. PMID 35859175
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The transcriptional landscape of the mammalian genome. Carninci P, et al. Science, 2005 Sep 2. PMID 16141072

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC68363

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of very-low-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    apolipoprotein L 9a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162883.1 → NP_001156355.1  apolipoprotein L 9a

      See identical proteins and their annotated locations for NP_001156355.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encoded the same protein.
      Source sequence(s)
      AL772386, CJ058381
      Consensus CDS
      CCDS49660.1
      UniProtKB/TrEMBL
      Q6PF90, Q8VDU3
      Related
      ENSMUSP00000080468.4, ENSMUST00000081776.11
      Conserved Domains (1) summary
      pfam05461
      Location:1 → 310
      ApoL; Apolipoprotein L

    2. NM_001416010.1 → NP_001402939.1  apolipoprotein L 9a

      Status: VALIDATED

      Source sequence(s)
      AL772386
      UniProtKB/TrEMBL
      Q6PF90, Q8VDU3

    3. NM_001416011.1 → NP_001402940.1  apolipoprotein L 9a

      Status: VALIDATED

      Source sequence(s)
      AL772386
      UniProtKB/TrEMBL
      Q6PF90, Q8VDU3

    4. NM_001416012.1 → NP_001402941.1  apolipoprotein L 9a

      Status: VALIDATED

      Source sequence(s)
      AL772386
      UniProtKB/TrEMBL
      Q6PF90, Q8VDU3

    5. NM_001416013.1 → NP_001402942.1  apolipoprotein L 9a

      Status: VALIDATED

      Source sequence(s)
      AL772386
      UniProtKB/TrEMBL
      Q6PF90, Q8VDU3

    6. NM_173786.2 → NP_776147.1  apolipoprotein L 9a

      See identical proteins and their annotated locations for NP_776147.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encoded the same protein.
      Source sequence(s)
      AL772386
      Consensus CDS
      CCDS49660.1
      UniProtKB/TrEMBL
      Q6PF90, Q8VDU3
      Related
      ENSMUSP00000086875.6, ENSMUST00000089452.6
      Conserved Domains (1) summary
      pfam05461
      Location:1 → 310
      ApoL; Apolipoprotein L

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      77287989..77295280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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