Eml2 echinoderm microtubule associated protein like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eml2provided by MGI
Official Full Name: echinoderm microtubule associated protein like 2provided by MGI
Primary source: MGI:MGI:1919455
See related: Ensembl:ENSMUSG00000040811 AllianceGenome:MGI:1919455
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EMAP-2; 1600029N02Rik
Summary: Predicted to enable ionotropic glutamate receptor binding activity and microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization; negative regulation of microtubule polymerization; and regulation of microtubule nucleation. Predicted to be located in cytoplasm and microtubule. Predicted to colocalize with mitotic spindle. Is expressed in genitourinary system; gut gland; heart; nervous system; and retina. Orthologous to human EML2 (EMAP like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 25.4), cortex adult (RPKM 23.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 9.46 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (18910322..18940407)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19176421..19206482)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of microtubule nucleation	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule nucleation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
colocalizes_with mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with mitotic spindle	ISO Inferred from Sequence Orthology more info
colocalizes_with mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: echinoderm microtubule-associated protein-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162996.2 → NP_001156468.1 echinoderm microtubule-associated protein-like 2 isoform 2

See identical proteins and their annotated locations for NP_001156468.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 3. These differences cause translation initiation at a novel AUG and result in an isoform (2) with a shorter and distinct N-terminus, compared to isoform 3.

Source sequence(s)

AC145199

Consensus CDS

CCDS85224.1

UniProtKB/Swiss-Prot

E9QK48, Q7TNG5, Q9DAS8

Related

ENSMUSP00000112447.3, ENSMUST00000120595.8

Conserved Domains (4) summary

COG2319
Location:76 → 497

WD40; WD40 repeat [General function prediction only]

pfam03451
Location:19 → 91

HELP; HELP motif

sd00039
Location:297 → 335

7WD40; WD40 repeat [structural motif]

cl02567
Location:348 → 647

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001347582.2 → NP_001334511.1 echinoderm microtubule-associated protein-like 2 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes the longest isoform (3).

Source sequence(s)

AC145199

Consensus CDS

CCDS85223.1

UniProtKB/TrEMBL

E9QK48

Related

ENSMUSP00000112491.2, ENSMUST00000117338.8
NM_028153.2 → NP_082429.1 echinoderm microtubule-associated protein-like 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and coding region, compared to variant 3. These differences cause translation initiation at a novel AUG and result in an isoform (1) with a shorter and distinct N-terminus, compared to isoform 3.

Source sequence(s)

AC145199

Consensus CDS

CCDS52055.1

UniProtKB/Swiss-Prot

Q7TNG5

Related

ENSMUSP00000037654.9, ENSMUST00000048502.10

Conserved Domains (4) summary

COG2319
Location:95 → 516

WD40; WD40 repeat [General function prediction only]

pfam03451
Location:19 → 110

HELP; HELP motif

sd00039
Location:316 → 354

7WD40; WD40 repeat [structural motif]

cl02567
Location:367 → 666

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

18910322..18940407

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250714.3 → XP_011249016.1 echinoderm microtubule-associated protein-like 2 isoform X1

Conserved Domains (4) summary

COG2319
Location:267 → 688

WD40; WD40 repeat [General function prediction only]

sd00039
Location:401 → 438

7WD40; WD40 repeat [structural motif]

pfam03451
Location:210 → 282

HELP; HELP motif

cl29593
Location:695 → 840

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011250715.2 → XP_011249017.1 echinoderm microtubule-associated protein-like 2 isoform X2

Conserved Domains (5) summary

COG2319
Location:222 → 643

WD40; WD40 repeat [General function prediction only]

sd00039
Location:356 → 393

7WD40; WD40 repeat [structural motif]

pfam03451
Location:165 → 237

HELP; HELP motif

cl01090
Location:14 → 69

SlyX

cl29593
Location:650 → 795

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030243010.1 → XP_030098870.1 echinoderm microtubule-associated protein-like 2 isoform X4

Conserved Domains (3) summary

COG2319
Location:22 → 381

WD40; WD40 repeat [General function prediction only]

sd00039
Location:181 → 219

7WD40; WD40 repeat [structural motif]

cl29593
Location:302 → 532

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011250719.2 → XP_011249021.1 echinoderm microtubule-associated protein-like 2 isoform X3

See identical proteins and their annotated locations for XP_011249021.1

Conserved Domains (4) summary

COG2319
Location:61 → 482

WD40; WD40 repeat [General function prediction only]

sd00039
Location:282 → 320

7WD40; WD40 repeat [structural motif]

pfam03451
Location:4 → 76

HELP; HELP motif

cl29593
Location:489 → 634

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011250718.3 → XP_011249020.1 echinoderm microtubule-associated protein-like 2 isoform X3

See identical proteins and their annotated locations for XP_011249020.1

Conserved Domains (4) summary

COG2319
Location:61 → 482

WD40; WD40 repeat [General function prediction only]

sd00039
Location:282 → 320

7WD40; WD40 repeat [structural motif]

pfam03451
Location:4 → 76

HELP; HELP motif

cl29593
Location:489 → 634

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...