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    Tnik TRAF2 and NCK interacting kinase [ Mus musculus (house mouse) ]

    Gene ID: 665113, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tnikprovided by MGI
    Official Full Name
    TRAF2 and NCK interacting kinaseprovided by MGI
    Primary source
    MGI:MGI:1916264
    See related
    Ensembl:ENSMUSG00000027692 AllianceGenome:MGI:1916264
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500031A17Rik; 4831440I19Rik; C530008O15Rik; C630040K21Rik
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 54. Orthologous to human TNIK (TRAF2 and NCK interacting kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 7.4), cortex adult (RPKM 5.7) and 18 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tnik in Genome Data Viewer
    Location:
    3 A3; 3 11.92 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (28317362..28724734)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (28261901..28670585)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07254 Neighboring gene phospholipase D1 Neighboring gene STARR-seq mESC enhancer starr_07256 Neighboring gene STARR-seq mESC enhancer starr_07258 Neighboring gene STARR-seq mESC enhancer starr_07259 Neighboring gene predicted gene, 42196 Neighboring gene predicted gene, 54170 Neighboring gene STARR-seq mESC enhancer starr_07260 Neighboring gene microRNA 466q Neighboring gene VISTA enhancer mm492 Neighboring gene STARR-seq mESC enhancer starr_07263 Neighboring gene STARR-seq mESC enhancer starr_07264 Neighboring gene STARR-seq mESC enhancer starr_07265 Neighboring gene RIKEN cDNA 1700112D23 gene Neighboring gene predicted gene, 52603 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 2 Neighboring gene predicted pseudogene 6505

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0551, MGC189819, MGC189859

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microvillus assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of dendrite morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in postsynaptic density, intracellular component ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    traf2 and NCK-interacting protein kinase
    NP_001156479.1
    NP_001156480.1
    NP_001156481.1
    NP_081186.1
    XP_006535580.1
    XP_006535581.1
    XP_006535582.1
    XP_006535583.1
    XP_006535584.1
    XP_011248006.1
    XP_011248007.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163007.1NP_001156479.1  traf2 and NCK-interacting protein kinase isoform 2

      See identical proteins and their annotated locations for NP_001156479.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal, in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) missing an 8 aa protein segment compared to isoform 1.
      Source sequence(s)
      BC050868, CK620825
      Consensus CDS
      CCDS50878.1
      UniProtKB/TrEMBL
      B2RXX2, B9EKN8
      Related
      ENSMUSP00000124876.3, ENSMUST00000159680.9
      Conserved Domains (2) summary
      smart00036
      Location:10341332
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
    2. NM_001163008.1NP_001156480.1  traf2 and NCK-interacting protein kinase isoform 3

      See identical proteins and their annotated locations for NP_001156480.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two internal, in-frame coding exons compared to variant 1, resulting in a shorter isoform (3) missing two protein segments compared to isoform 1.
      Source sequence(s)
      BC050868
      Consensus CDS
      CCDS50879.1
      UniProtKB/Swiss-Prot
      P83510
      UniProtKB/TrEMBL
      B2RXX2
      Related
      ENSMUSP00000124681.3, ENSMUST00000159236.9
      Conserved Domains (3) summary
      smart00036
      Location:10051303
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
    3. NM_001163009.1NP_001156481.1  traf2 and NCK-interacting protein kinase isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal, in-frame coding exon, and differs at the 3' end compared to variant 1, resulting in a longer isoform (4) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC121268, AI115107, BC050868, CF531435, CK620825
      UniProtKB/TrEMBL
      B2RY17
      Related
      ENSMUST00000162037.9
      Conserved Domains (3) summary
      smart00036
      Location:10341326
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
    4. NM_026910.1NP_081186.1  traf2 and NCK-interacting protein kinase isoform 1

      See identical proteins and their annotated locations for NP_081186.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      BC050868, CD348964, CK620825
      Consensus CDS
      CCDS50877.1
      UniProtKB/TrEMBL
      B2RQ80, B2RXX2
      Related
      ENSMUSP00000125081.3, ENSMUST00000160307.9
      Conserved Domains (3) summary
      smart00036
      Location:10421340
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      28317362..28724734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535519.4XP_006535582.1  traf2 and NCK-interacting protein kinase isoform X3

      UniProtKB/TrEMBL
      B2RXX2
      Conserved Domains (2) summary
      smart00036
      Location:10451343
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
    2. XM_006535517.4XP_006535580.1  traf2 and NCK-interacting protein kinase isoform X1

      UniProtKB/TrEMBL
      B2RY17
      Conserved Domains (2) summary
      smart00036
      Location:10451337
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
    3. XM_006535518.4XP_006535581.1  traf2 and NCK-interacting protein kinase isoform X2

      UniProtKB/TrEMBL
      B2RY17
      Conserved Domains (2) summary
      smart00036
      Location:10421334
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
    4. XM_006535521.4XP_006535584.1  traf2 and NCK-interacting protein kinase isoform X5

      UniProtKB/TrEMBL
      B2RXX2, E9PUL9
      Related
      ENSMUSP00000124011.2, ENSMUST00000160518.8
      Conserved Domains (2) summary
      smart00036
      Location:10131311
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
    5. XM_006535520.4XP_006535583.1  traf2 and NCK-interacting protein kinase isoform X4

      UniProtKB/TrEMBL
      B2RY17
      Conserved Domains (2) summary
      smart00036
      Location:10161308
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
    6. XM_011249704.4XP_011248006.1  traf2 and NCK-interacting protein kinase isoform X6

      UniProtKB/TrEMBL
      B2RY17
      Conserved Domains (2) summary
      smart00036
      Location:9901282
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:1258
      PKc_like; Protein Kinases, catalytic domain
    7. XM_011249705.4XP_011248007.1  traf2 and NCK-interacting protein kinase isoform X7

      UniProtKB/TrEMBL
      B2RY17
      Conserved Domains (2) summary
      smart00036
      Location:9611253
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:1258
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_004941378.1 RNA Sequence

      Related
      ENSMUST00000160934.8