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    Trdmt1 tRNA aspartic acid methyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 13434, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trdmt1provided by MGI
    Official Full Name
    tRNA aspartic acid methyltransferase 1provided by MGI
    Primary source
    MGI:MGI:1274787
    See related
    Ensembl:ENSMUSG00000026723 AllianceGenome:MGI:1274787
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dnmt2; Rnmt2; met-2; m.MmuIIP
    Summary
    Enables tRNA (cytidine-5-)-methyltransferase activity. Involved in tRNA methylation and tRNA stabilization. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; olfactory epithelium; and thyroid gland. Orthologous to human TRDMT1 (tRNA aspartic acid methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 2.1), bladder adult (RPKM 2.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trdmt1 in Genome Data Viewer
    Location:
    2 A1; 2 10.0 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (13509690..13549475, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (13504879..13544797, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5888 Neighboring gene STARR-seq mESC enhancer starr_03701 Neighboring gene STARR-seq mESC enhancer starr_03702 Neighboring gene predicted gene 13270 Neighboring gene cubilin Neighboring gene predicted gene, 57686 Neighboring gene STARR-seq mESC enhancer starr_03707 Neighboring gene STARR-positive B cell enhancer ABC_E11702 Neighboring gene STARR-seq mESC enhancer starr_03708 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:13466299-13466482 Neighboring gene predicted gene, 54102 Neighboring gene predicted gene 9875

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse Paternal RNAs Initiate a Pattern of Metabolic Disorders in a Line-Dependent Manner. Satir-Basaran G, et al. Front Genet, 2022. PMID 35419033, Free PMC Article
    2. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. Zhang Y, et al. Nat Cell Biol, 2018 May. PMID 29695786, Free PMC Article
    3. Downregulation of methyltransferase Dnmt2 results in condition-dependent telomere shortening and senescence or apoptosis in mouse fibroblasts. Lewinska A, et al. J Cell Physiol, 2017 Dec. PMID 28177119
    4. Dnmt2/Trdmt1 as Mediator of RNA Polymerase II Transcriptional Activity in Cardiac Growth. Ghanbarian H, et al. PLoS One, 2016. PMID 27270731, Free PMC Article
    5. The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis. Tuorto F, et al. EMBO J, 2015 Sep 14. PMID 26271101, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion.
      Title: Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion.
    2. Dnmt2-null sperm block maternal transmission of a paramutant phenotypedagger.
      Title: Dnmt2-null sperm block maternal transmission of a paramutant phenotype†.
    3. We also show that Q-dependent stimulation of Dnmt2 is conserved in mice. Our findings reveal a direct mechanism for the regulation of translational speed and fidelity in eukaryotes by a nutrient originating from bacteria.
      Title: Queuine links translational control in eukaryotes to a micronutrient from bacteria.
    4. Dnmt2 functions as a genetic factor that is essential in shaping the sperm RNA 'coding signature that is responsible for the intergenerational transmission of HFD-induced paternal metabolic disorders.
      Title: Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs.
    5. Dnmt2 may promote lifespan in the control conditions and survival during stress conditions in mouse fibroblasts.
      Title: Downregulation of methyltransferase Dnmt2 results in condition-dependent telomere shortening and senescence or apoptosis in mouse fibroblasts.
    6. Dnmt2 plays an unexpected role for regulation of cardiac growth by modulating activity of the P-TEFb complex.
      Title: Dnmt2/Trdmt1 as Mediator of RNA Polymerase II Transcriptional Activity in Cardiac Growth.
    7. Treatment of aged mice and their derived macrophages with methyltransferase inhibitor (2)-epigallocatechin-3-gallate (EGCG) or specific DNA methyltransferase 2 (DNMT2) siRNA restored the expression of Atg5 and LC3 in vivo and in vitro.
      Title: Aging is associated with hypermethylation of autophagy genes in macrophages.
    8. Dnmt2 plays an important role in haematopoiesis and define a novel function of C38 tRNA methylation in the discrimination of near-cognate codons, thereby ensuring accurate polypeptide synthesis.
      Title: The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis.
    9. these findings uncover a novel function of Dnmt2 in RNA-mediated epigenetic heredity
      Title: RNA-mediated epigenetic heredity requires the cytosine methyltransferase Dnmt2.
    10. Dnmt2-dependent methylomes lack defined DNA methylation patterns.
      Title: Dnmt2-dependent methylomes lack defined DNA methylation patterns.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (cytidine-5-)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA (cytidine-5-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in tRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (cytosine(38)-C(5))-methyltransferase
    Names
    DNA (cytosine-5)-methyltransferase-like protein 2
    DNA MTase homolog MmuIIP
    DNA methyltransferase 2
    DNA methyltransferase homolog MmuIIP
    tRNA (cytosine-5-)-methyltransferase
    NP_001403924.1
    NP_001403925.1
    NP_001403926.1
    NP_001403927.1
    NP_001403928.1
    NP_034197.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416995.1 → NP_001403924.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL772303, AL773538
      UniProtKB/TrEMBL
      Q8C7F0

    2. NM_001416996.1 → NP_001403925.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL772303, AL773538
      UniProtKB/TrEMBL
      Q8C7F0

    3. NM_001416997.1 → NP_001403926.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL772303, AL773538

    4. NM_001416998.1 → NP_001403927.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL772303, AL773538

    5. NM_001416999.1 → NP_001403928.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL772303, AL773538

    6. NM_010067.5 → NP_034197.3  tRNA (cytosine(38)-C(5))-methyltransferase isoform 1

      See identical proteins and their annotated locations for NP_034197.3

      Status: VALIDATED

      Source sequence(s)
      AL772303, AL773538
      Consensus CDS
      CCDS15695.1
      UniProtKB/Swiss-Prot
      O35212, O55055
      UniProtKB/TrEMBL
      Q5I0V6, Q8C7F0
      Related
      ENSMUSP00000114572.2, ENSMUST00000124488.7
      Conserved Domains (1) summary
      cd00315
      Location:4 → 391
      Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

    RNA

    1. NR_184406.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772303, AL773538

    2. NR_184407.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772303, AL773538

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      13509690..13549475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O55055.2 GenPept UniProtKB/Swiss-Prot:O55055

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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