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    Marcal1 Marcal1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33709, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Marcal1provided by FlyBase
    Official Full Name
    Marcal1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031655
    Locus tag
    Dmel_CG3753
    See related
    AllianceGenome:FB:FBgn0031655
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3753; Dmel\CG3753; dmHARP; HARP; Marca1; MARCAL1
    Summary
    Enables ATP-dependent DNA/DNA annealing activity and four-way junction helicase activity. Involved in DNA rewinding and heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing. Located in nucleus and polytene chromosome interband. Used to study Schimke immuno-osseous dysplasia. Human ortholog(s) of this gene implicated in Schimke immuno-osseous dysplasia. Orthologous to human SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Marcal1 in Genome Data Viewer
    Location:
    25B4-25B4; 2-14 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4955509..4958292)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4955509..4958292)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Jonah 25Bii Neighboring gene Jonah 25Bi Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43824 Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit i

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The annealing helicase and branch migration activities of Drosophila HARP. Kassavetis GA, et al. PLoS One, 2014. PMID 24866343, Free PMC Article
    2. The effect of repeat length on Marcal1-dependent single-strand annealing in Drosophila. Dewey EB, et al. Genetics, 2023 Jan 12. PMID 36303322, Free PMC Article
    3. Annealing of Complementary DNA Sequences During Double-Strand Break Repair in Drosophila Is Mediated by the Ortholog of SMARCAL1. Holsclaw JK, et al. Genetics, 2017 May. PMID 28258182, Free PMC Article
    4. An RNAi-Based Candidate Screen for Modifiers of the CHD1 Chromatin Remodeler and Assembly Factor in Drosophila melanogaster. Kim S, et al. G3 (Bethesda), 2015 Nov 23. PMID 26596648, Free PMC Article
    5. The XNP remodeler targets dynamic chromatin in Drosophila. Schneiderman JI, et al. Proc Natl Acad Sci U S A, 2009 Aug 25. PMID 19706533, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The effect of repeat length on Marcal1-dependent single-strand annealing in Drosophila.
      Title: The effect of repeat length on Marcal1-dependent single-strand annealing in Drosophila.
    2. limination of the ATP-binding activity of Marcal1 also reduced annealing-dependent repair, suggesting that the annealing activity requires translocation along DNA. Unlike the null mutant, however, the ATP-binding defect mutant showed reduced end joining, shedding light on the interaction between SDSA and end-joining pathways.
      Title: Annealing of Complementary DNA Sequences During Double-Strand Break Repair in Drosophila Is Mediated by the Ortholog of SMARCAL1.
    3. deficiency of a SMARCAL1 ortholog altering the chromatin structure of a gene
      Title: Chromatin changes in SMARCAL1 deficiency: A hypothesis for the gene expression alterations of Schimke immuno-osseous dysplasia.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA/DNA annealing activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent DNA/DNA annealing activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP-dependent DNA/DNA annealing activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA rewinding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in replication fork reversal IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nuclear replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in polytene chromosome interband IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Marcal1
    Names
    CG3753-PA
    Marcal1-PA
    dsmarcal1
    hepA-related protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4955509..4958292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135039.2 → NP_608883.1  Marcal1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608883.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMX6
      Related
      FBpp0078631
      Conserved Domains (4) summary
      smart00487
      Location:239 → 420
      DEXDc; DEAD-like helicases superfamily
      cd00046
      Location:265 → 394
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:518 → 632
      Helicase_C; Helicase conserved C-terminal domain
      pfam07443
      Location:160 → 215
      HARP; HepA-related protein (HARP)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMX6.2 Q9VMX6

    Gene LinkOut

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