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    kel kelch [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35084, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kelprovided by FlyBase
    Official Full Name
    kelchprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001301
    Locus tag
    Dmel_CG7210
    See related
    AllianceGenome:FB:FBgn0001301
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7210; Dm.Ring_canal/KELC_DROME; Dmel\CG7210; Kel; Kelch
    Summary
    Enables actin binding activity. Involved in actin cytoskeleton organization; cellularization; and oogenesis. Located in female germline ring canal. Is expressed in several structures, including anlage in statu nascendi; central brain anlage in statu nascendi; dorsal ectoderm anlage; gonad; and ring canal. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human KLHL2 (kelch like family member 2) and KLHL3 (kelch like family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kel in Genome Data Viewer
    Location:
    36E5-36E6; 2-53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18129884..18138083, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18129884..18138083, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor-like 36b Neighboring gene Suppressor of cytokine signaling at 36E Neighboring gene long non-coding RNA:CR44478 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila kelch motif is derived from a common enzyme fold. Bork P, et al. J Mol Biol, 1994 Mar 11. PMID 8126718
    2. kelch encodes a component of intercellular bridges in Drosophila egg chambers. Xue F, et al. Cell, 1993 Mar 12. PMID 8453663
    3. Formation of actin filament bundles in the ring canals of developing Drosophila follicles. Tilney LG, et al. J Cell Biol, 1996 Apr. PMID 8601614, Free PMC Article
    4. Stimulation of stop codon readthrough: frequent presence of an extended 3' RNA structural element. Firth AE, et al. Nucleic Acids Res, 2011 Aug. PMID 21525127, Free PMC Article
    5. Morphogenesis of Drosophila ovarian ring canals. Robinson DN, et al. Development, 1994 Jul. PMID 7925006

    See all (125) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. present genetic evidence consistent with HtsRC being the CRL3(Kelch) substrate, as well as biochemical evidence indicating that HtsRC is ubiquitylated and degraded by the proteasome.
      Title: Targeted substrate degradation by Kelch controls the actin cytoskeleton during ring canal expansion.
    2. results demonstrate that Kelch promotes ring canal cytoskeleton growth primarily through its activity as cullin-RING E3 ubiquitin ligase component
      Title: Actin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase.
    3. COP9 limits dendritic branching via Cullin3-dependent degradation of the actin-crosslinking BTB-domain protein Kelch
      Title: COP9 limits dendritic branching via Cullin3-dependent degradation of the actin-crosslinking BTB-domain protein Kelch.
    4. demonstrate that association of Drosophila KEL with Cullin-3, likely in a cullin-RING ligase, is essential for the growth of Drosophila female germline ring canals.
      Title: Drosophila Kelch functions with Cullin-3 to organize the ring canal actin cytoskeleton.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellularization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female germline ring canal formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in female germline ring canal formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in follicle cell of egg chamber migration HMP PubMed 
    involved_in oocyte karyosome formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis HMP PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ovarian fusome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ovarian nurse cell to oocyte transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in female germline ring canal IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in female germline ring canal inner rim TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in germline ring canal IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in germline ring canal TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kelch
    Names
    CG7210-PA
    CG7210-PB
    kel-PA
    kel-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18129884..18138083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165242.2 → NP_724095.1  kelch, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724095.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q04652
      Related
      FBpp0080595
      Conserved Domains (5) summary
      smart00612
      Location:497 → 543
      Kelch; Kelch domain
      PHA03098
      Location:150 → 675
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:439 → 482
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:147 → 250
      BTB; BTB/POZ domain
      pfam07707
      Location:258 → 359
      BACK; BTB And C-terminal Kelch

    2. NM_057241.3 → NP_476589.4  kelch, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476589.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F0JAF0, Q04652, Q04653, Q86PA7, Q9VJA2
      Related
      FBpp0080596
      Conserved Domains (5) summary
      smart00612
      Location:497 → 543
      Kelch; Kelch domain
      PHA03098
      Location:150 → 675
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:439 → 482
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:147 → 250
      BTB; BTB/POZ domain
      pfam07707
      Location:258 → 359
      BACK; BTB And C-terminal Kelch
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04652.4 Q04652

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