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    Nedd8 Nedd8 ubiquitin like modifier [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35151, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nedd8provided by FlyBase
    Official Full Name
    Nedd8 ubiquitin like modifierprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032725
    Locus tag
    Dmel_CG10679
    See related
    AllianceGenome:FB:FBgn0032725
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10679; Dmel\CG10679; dNEDD8; Nedd; nedd8; NEDD8
    Summary
    Enables protein tag activity. Involved in several processes, including female germ-line stem cell population maintenance; negative regulation of smoothened signaling pathway; and protein neddylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human NEDD8 (NEDD8 ubiquitin like modifier). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nedd8 in Genome Data Viewer
    Location:
    37B7-37B7; 2-54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18951006..18951837, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18951006..18951837, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44741

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity. Suisse A, et al. Fly (Austin), 2018. PMID 29355077, Free PMC Article
    2. Deneddylase 1 regulates deneddylase activity of the Cop9 signalosome in Drosophila melanogaster. Kim K, et al. Insect Sci, 2017 Feb. PMID 26332639
    3. Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23. Blount JR, et al. Nat Commun, 2014 Aug 21. PMID 25144244, Free PMC Article
    4. Dual regulation of dendritic morphogenesis in Drosophila by the COP9 signalosome. Djagaeva I, et al. PLoS One, 2009 Oct 26. PMID 19855832, Free PMC Article
    5. DEN1 deneddylates non-cullin proteins in vivo. Chan Y, et al. J Cell Sci, 2008 Oct 1. PMID 18782863

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic analyses indicate that a balance between neddylation and deneddylation maintained by DEN1 is crucial for animal viability.
      Title: DEN1 deneddylates non-cullin proteins in vivo.
    2. the Cul1-based SCF complex requires Nedd8 modification for the degradation processes of Ci, Arm, and CycE in vivo
      Title: Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tag activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tag activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein neddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Nedd8 ubiquitin like modifier
    Names
    CG10679-PA
    CG10679-PB
    Nedd8-PA
    Nedd8-PB
    neural precursor cell-expressed developmentally downregulated

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18951006..18951837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299141.1 → NP_001286070.1  Nedd8 ubiquitin like modifier, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286070.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q29QE5, Q9VJ33
      UniProtKB/TrEMBL
      X2J935
      Conserved Domains (1) summary
      cd01806
      Location:3 → 76
      Ubl_NEDD8; ubiquitin-like (Ubl) domain found in neural precursor cell expressed developmentally down-regulated protein 8 (NEDD8) and similar proteins

    2. NM_136075.3 → NP_609919.1  Nedd8 ubiquitin like modifier, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609919.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q29QE5, Q9VJ33
      UniProtKB/TrEMBL
      X2J935
      Related
      FBpp0080733
      Conserved Domains (1) summary
      cd01806
      Location:3 → 76
      Ubl_NEDD8; ubiquitin-like (Ubl) domain found in neural precursor cell expressed developmentally down-regulated protein 8 (NEDD8) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJ33.1 Q9VJ33
    X2J935 X2J935

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