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    l(2)k14505 lethal (2) k14505 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35399, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(2)k14505provided by FlyBase
    Official Full Name
    lethal (2) k14505provided by FlyBase
    Primary source
    FLYBASE:FBgn0021856
    Locus tag
    Dmel_CG8674
    See related
    AllianceGenome:FB:FBgn0021856
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8674; Dmel\CG8674
    Summary
    Predicted to be involved in mitochondrial proton-transporting ATP synthase complex assembly. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in organism and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 1. Orthologous to human ATPAF2 (ATP synthase mitochondrial F1 complex assembly factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(2)k14505 in Genome Data Viewer
    Location:
    39C1-39C1; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21261168..21262411)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21261168..21262411)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45713 Neighboring gene uncharacterized protein Neighboring gene mir-9374 stem loop Neighboring gene Hormone receptor-like in 39 Neighboring gene mir-4974 stem loop Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cyclin E-dependent protein kinase activity regulates niche retention of Drosophila ovarian follicle stem cells. Wang ZA, et al. Proc Natl Acad Sci U S A, 2009 Dec 22. PMID 19966222, Free PMC Article
    2. Genetic maps of the proximal half of chromosome arm 2L of Drosophila melanogaster. Levine SG, et al. Genome, 2007 Feb. PMID 17546078
    3. Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS. Wang ZA, et al. Nat Commun, 2012 Apr 3. PMID 22473013, Free PMC Article
    4. Mitochondrial DNA quality control in the female germline requires a unique programmed mitophagy. Palozzi JM, et al. Cell Metab, 2022 Nov 1. PMID 36323236
    5. The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication. Zhang Y, et al. EMBO J, 2016 May 17. PMID 27053724, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial proton-transporting ATP synthase complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton-transporting ATP synthase complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lethal (2) k14505
    Names
    CG8674-PA
    CG8674-PB
    l(2)k14505-PA
    l(2)k14505-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21261168..21262411
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273739.1 → NP_001260668.1  lethal (2) k14505, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260668.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3M6, Q9VID7
      Conserved Domains (1) summary
      pfam07542
      Location:39 → 159
      ATP12; ATP12 chaperone protein

    2. NM_136258.2 → NP_610102.1  lethal (2) k14505, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610102.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3M6, Q9VID7
      Related
      FBpp0081011
      Conserved Domains (1) summary
      pfam07542
      Location:39 → 159
      ATP12; ATP12 chaperone protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T3M6 Q8T3M6
    Q9VID7 Q9VID7

    Gene LinkOut

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