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    tomboy40 tomboy40 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35553, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tomboy40provided by FlyBase
    Official Full Name
    tomboy40provided by FlyBase
    Primary source
    FLYBASE:FBgn0033074
    Locus tag
    Dmel_CG8330
    See related
    AllianceGenome:FB:FBgn0033074
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8330; Dmel\CG8330; Tomboy40
    Summary
    Predicted to enable protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrion. Part of mitochondrial outer membrane translocase complex. Is expressed in adult head; germline cell; and testis. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to human TOMM40 (translocase of outer mitochondrial membrane 40) and TOMM40L (translocase of outer mitochondrial membrane 40 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tomboy40 in Genome Data Viewer
    Location:
    42A14-42A14; 2-55 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6225634..6226884)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2113139..2114389)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44161 Neighboring gene Tetratricopeptide repeat domain 7 Neighboring gene bicoid-interacting protein 3 Neighboring gene Phospholipase D Neighboring gene long non-coding RNA:CR46075

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Germ-line specific variants of components of the mitochondrial outer membrane import machinery in Drosophila. Hwa JJ, et al. FEBS Lett, 2004 Aug 13. PMID 15304338
    2. An in vivo screen for neuronal genes involved in obesity identifies Diacylglycerol kinase as a regulator of insulin secretion. Trinh I, et al. Mol Metab, 2019 Jan. PMID 30389349, Free PMC Article
    3. Quality of regulatory elements in Drosophila retrogenes. Bai Y, et al. Genomics, 2009 Jan. PMID 18848618, Free PMC Article
    4. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Lu Y, et al. Nat Commun, 2016 Feb 1. PMID 26833246, Free PMC Article
    5. The Bin3 RNA methyltransferase is required for repression of caudal translation in the Drosophila embryo. Singh N, et al. Dev Biol, 2011 Apr 1. PMID 21262214

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial outer membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial outer membrane translocase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tomboy40
    Names
    CG8330-PA
    dtomboy40
    tomboy40-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6225634..6226884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136369.2 → NP_610213.1  tomboy40 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610213.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z6L1, Q6NN68
      UniProtKB/TrEMBL
      H0RNC6
      Related
      FBpp0085338
      Conserved Domains (1) summary
      cd07305
      Location:53 → 340
      Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z6L1.1 A1Z6L1

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