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    Drat Death resistor Adh domain containing target [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35687, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dratprovided by FlyBase
    Official Full Name
    Death resistor Adh domain containing targetprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033188
    Locus tag
    Dmel_CG1600
    See related
    AllianceGenome:FB:FBgn0033188
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1600; Dmel\CG1600
    Summary
    Predicted to enable alcohol dehydrogenase (NADP+) activity. Involved in cellular response to ethanol and response to hypoxia. Is expressed in several structures, including adult head; amnioserosa; embryonic/larval corpus allatum; foregut primordium; and mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Drat in Genome Data Viewer
    Location:
    43D2-43D3; 2-56 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7526118..7532981, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3413623..3420486, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class G Neighboring gene Origin recognition complex subunit 1 Neighboring gene long non-coding RNA:CR44209 Neighboring gene Cytochrome b5 Neighboring gene Glycerophosphate oxidase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic changes in gene expression and alternative splicing mediate the response to acute alcohol exposure in Drosophila melanogaster. Signor S, et al. Heredity (Edinb), 2018 Oct. PMID 30143789, Free PMC Article
    2. Evolution of Plasticity in Response to Ethanol between Sister Species with Different Ecological Histories (Drosophila melanogaster and D. simulans). Signor SA. Am Nat, 2020 Nov. PMID 33064591
    3. Distinct mechanisms underlying tolerance to intermittent and constant hypoxia in Drosophila melanogaster. Azad P, et al. PLoS One, 2009. PMID 19401761, Free PMC Article
    4. RNA helicase Spn-E is required to maintain Aub and AGO3 protein levels for piRNA silencing in the germline of Drosophila. Ryazansky SS, et al. Eur J Cell Biol, 2016 Sep. PMID 27320195
    5. Fine scale analysis of gene expression in Drosophila melanogaster gonads reveals Programmed cell death 4 promotes the differentiation of female germline stem cells. Cash AC, et al. BMC Dev Biol, 2012 Jan 17. PMID 22252300, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in alcohol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    death resistor Adh domain containing target
    Names
    CG1600-PA
    CG1600-PB
    CG1600-PC
    CG1600-PD
    Drat-PA
    Drat-PB
    Drat-PC
    Drat-PD
    NP_001260779.1
    NP_610293.3
    NP_724572.1
    NP_724573.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7526118..7532981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165538.2 → NP_724572.1  death resistor Adh domain containing target, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724572.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3LFG9, G3LFI2, Q0E9G4
      Related
      FBpp0088030
      Conserved Domains (2) summary
      COG0604
      Location:89 → 377
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]
      cl16912
      Location:91 → 375
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

    2. NM_001273850.1 → NP_001260779.1  death resistor Adh domain containing target, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260779.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3LFG9, G3LFI2, Q0E9G4
      Conserved Domains (2) summary
      COG0604
      Location:89 → 377
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]
      cl16912
      Location:91 → 375
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

    3. NM_165539.2 → NP_724573.1  death resistor Adh domain containing target, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724573.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3LFG9, G3LFI2, Q0E9G4
      Related
      FBpp0088032
      Conserved Domains (2) summary
      COG0604
      Location:89 → 377
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]
      cl16912
      Location:91 → 375
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

    4. NM_136449.3 → NP_610293.3  death resistor Adh domain containing target, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610293.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3LFG9, G3LFI2, Q961L4
      Related
      FBpp0088031
      Conserved Domains (2) summary
      COG0604
      Location:142 → 430
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]
      cl16912
      Location:144 → 428
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E9G4 Q0E9G4
    Q961L4 Q961L4

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