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    ADAM32 ADAM metallopeptidase domain 32 [ Homo sapiens (human) ]

    Gene ID: 203102, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ADAM32provided by HGNC
    Official Full Name
    ADAM metallopeptidase domain 32provided by HGNC
    Primary source
    HGNC:HGNC:15479
    See related
    Ensembl:ENSG00000197140 MIM:618602; AllianceGenome:HGNC:15479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. This gene is predominantly expressed in the testis. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
    Expression
    Restricted expression toward testis (RPKM 20.2) See more
    Orthologs
    all
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    Genomic context

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    See ADAM32 in Genome Data Viewer
    Location:
    8p11.22
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (39107529..39284917)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (39384664..39562013)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38965048..39142436)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38853156-38853678 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38853679-38854200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27277 Neighboring gene TM2 domain containing 2 Neighboring gene Sharpr-MPRA regulatory region 279 Neighboring gene ADAM metallopeptidase domain 9 Neighboring gene small nucleolar RNA, C/D box 38D Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:39038237-39039436 Neighboring gene ribosomal protein L3 pseudogene 10 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:39084432-39085631 Neighboring gene lysine acetyltransferase 2B pseudogene Neighboring gene ADAM metallopeptidase domain 5 (pseudogene)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of ADAM32 with testis-predominant gene expression. Choi I, et al. Gene, 2003 Jan 30. PMID 12568724
    2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. Zhang Z, et al. Protein Sci, 2004 Oct. PMID 15340161, Free PMC Article
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ26299, FLJ29004

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 32
    Names
    a disintegrin and metalloprotease domain 32
    a disintegrin and metalloproteinase domain 32
    metalloproteinase 12-like protein
    testicular tissue protein Li 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313994.1 → NP_001300923.1  disintegrin and metalloproteinase domain-containing protein 32 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks multiple alternate exons in the coding region and uses an alternate translation start site, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AC105091, AK300148, BC026169, BI559590
      Consensus CDS
      CCDS83286.1
      UniProtKB/TrEMBL
      B4DTC2, E7EPX8
      Related
      ENSP00000405978.2, ENST00000437682.6
      Conserved Domains (5) summary
      cd04269
      Location:194 → 312
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:313 → 376
      Disintegrin; Disintegrin
      pfam01562
      Location:45 → 150
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08516
      Location:380 → 494
      ADAM_CR; ADAM cysteine-rich
      pfam14797
      Location:615 → 687
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

    2. NM_145004.7 → NP_659441.4  disintegrin and metalloproteinase domain-containing protein 32 isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC105091, AC105185
      Consensus CDS
      CCDS47846.1
      UniProtKB/Swiss-Prot
      Q8TC27, Q8TC42
      UniProtKB/TrEMBL
      A0A140VJD9
      Related
      ENSP00000369238.4, ENST00000379907.9
      Conserved Domains (5) summary
      pfam00200
      Location:400 → 474
      Disintegrin; Disintegrin
      pfam01421
      Location:187 → 383
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:27 → 144
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08516
      Location:479 → 593
      ADAM_CR; ADAM cysteine-rich
      pfam14797
      Location:714 → 786
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      39107529..39284917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544433.3 → XP_011542735.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X2

      UniProtKB/TrEMBL
      A0A140VJD9
      Conserved Domains (6) summary
      cd04269
      Location:187 → 381
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:400 → 475
      Disintegrin; Disintegrin
      pfam01421
      Location:187 → 383
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:40 → 143
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08516
      Location:479 → 593
      ADAM_CR; ADAM cysteine-rich
      pfam14797
      Location:714 → 773
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

    2. XM_006716298.4 → XP_006716361.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X1

      UniProtKB/TrEMBL
      A0A140VJD9
      Conserved Domains (5) summary
      cd04269
      Location:187 → 381
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:400 → 475
      Disintegrin; Disintegrin
      pfam01421
      Location:187 → 383
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:40 → 143
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08516
      Location:479 → 593
      ADAM_CR; ADAM cysteine-rich

    3. XM_017013184.3 → XP_016868673.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X4

      UniProtKB/TrEMBL
      A0A140VJD9

    4. XM_006716299.3 → XP_006716362.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X7

      UniProtKB/TrEMBL
      E7ER82
      Related
      ENSP00000429422.1, ENST00000519315.5
      Conserved Domains (5) summary
      cd04269
      Location:187 → 305
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:306 → 369
      Disintegrin; Disintegrin
      pfam01562
      Location:40 → 143
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08516
      Location:373 → 487
      ADAM_CR; ADAM cysteine-rich
      pfam14797
      Location:608 → 680
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

    5. XM_011544434.3 → XP_011542736.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X6

      UniProtKB/TrEMBL
      E7ER82
      Conserved Domains (6) summary
      cd04269
      Location:187 → 308
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:327 → 402
      Disintegrin; Disintegrin
      pfam01421
      Location:187 → 310
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:40 → 143
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08516
      Location:406 → 520
      ADAM_CR; ADAM cysteine-rich
      pfam14797
      Location:641 → 713
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

    6. XM_017013183.3 → XP_016868672.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X3

      UniProtKB/TrEMBL
      A0A140VJD9

    7. XM_047421494.1 → XP_047277450.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X9

    8. XM_017013186.3 → XP_016868675.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X8

    9. XM_017013185.3 → XP_016868674.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X5

      UniProtKB/TrEMBL
      A0A140VJD9

    10. XM_017013188.2 → XP_016868677.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X11

    11. XM_017013187.2 → XP_016868676.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X10

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187577.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      13212..190632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328846.1 → XP_054184821.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X2

    2. XM_054328845.1 → XP_054184820.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X1

    3. XM_054328848.1 → XP_054184823.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X4

    4. XM_054328851.1 → XP_054184826.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X7

    5. XM_054328852.1 → XP_054184827.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X12

    6. XM_054328850.1 → XP_054184825.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X6

    7. XM_054328847.1 → XP_054184822.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X3

    8. XM_054328854.1 → XP_054184829.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X9

    9. XM_054328853.1 → XP_054184828.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X8

    10. XM_054328849.1 → XP_054184824.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X5

    11. XM_054328857.1 → XP_054184832.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X11

    12. XM_054328855.1 → XP_054184830.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X10

    13. XM_054328856.1 → XP_054184831.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X13

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      39384664..39562013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360000.1 → XP_054215975.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X2

    2. XM_054359999.1 → XP_054215974.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X1

    3. XM_054360002.1 → XP_054215977.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X4

    4. XM_054360005.1 → XP_054215980.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X7

    5. XM_054360006.1 → XP_054215981.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X14

    6. XM_054360004.1 → XP_054215979.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X6

    7. XM_054360001.1 → XP_054215976.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X3

    8. XM_054360008.1 → XP_054215983.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X9

    9. XM_054360007.1 → XP_054215982.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X8

    10. XM_054360003.1 → XP_054215978.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X5

    11. XM_054360010.1 → XP_054215985.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X11

    12. XM_054360009.1 → XP_054215984.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X10

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TC27.2 GenPept UniProtKB/Swiss-Prot:Q8TC27

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