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    NPIPA3 nuclear pore complex interacting protein family member A3 [ Homo sapiens (human) ]

    Gene ID: 642778, updated on 27-Nov-2024

    Summary

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    Official Symbol
    NPIPA3provided by HGNC
    Official Full Name
    nuclear pore complex interacting protein family member A3provided by HGNC
    Primary source
    HGNC:HGNC:41978
    See related
    Ensembl:ENSG00000224712 AllianceGenome:HGNC:41978
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in skin (RPKM 19.5), testis (RPKM 14.9) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See NPIPA3 in Genome Data Viewer
    Location:
    16p13.11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (14703411..14726342)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (14797268..14820199)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene bifunctional apoptosis regulator Neighboring gene RNA, U7 small nuclear 125 pseudogene Neighboring gene phospholipase A2 group X Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:14781374-14781874 Neighboring gene group 10 secretory phospholipase A2 Neighboring gene nuclear pore complex interacting protein family member A2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:14860458-14860958 Neighboring gene phospholipase A2 group XE, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling. Hornan DM, et al. Invest Ophthalmol Vis Sci, 2007 Dec. PMID 18055785
    2. USP2 Inhibits Lung Cancer Pathogenesis by Reducing ARID2 Protein Degradation via Ubiquitination. Zhu L, et al. Biomed Res Int, 2022. PMID 36567903, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    nuclear pore complex-interacting protein family member A3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277323.2 → NP_001264252.1  nuclear pore complex-interacting protein family member A3 isoform 2

      See identical proteins and their annotated locations for NP_001264252.1

      Status: VALIDATED

      Source sequence(s)
      AC009167, AC136443
      Consensus CDS
      CCDS59262.1
      UniProtKB/Swiss-Prot
      F8WFD2
      UniProtKB/TrEMBL
      A0A067ZUL9
      Conserved Domains (1) summary
      pfam06409
      Location:22 → 287
      NPIP; Nuclear pore complex interacting protein (NPIP)

    2. NM_001395487.1 → NP_001382416.1  nuclear pore complex-interacting protein family member A3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC009167, AC136443
      Consensus CDS
      CCDS92114.1
      UniProtKB/TrEMBL
      A0A067ZUL9, E9PNV8
      Related
      ENSP00000437133.1, ENST00000531598.7
      Conserved Domains (2) summary
      pfam06409
      Location:46 → 307
      NPIP; Nuclear pore complex interacting protein (NPIP)
      cl17068
      Location:2 → 41
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      14703411..14726342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522576.3 → XP_011520878.2  nuclear pore complex-interacting protein family member A3 isoform X1

      UniProtKB/TrEMBL
      A0A067ZUL9

    2. XM_011522583.4 → XP_011520885.1  nuclear pore complex-interacting protein family member A3 isoform X6

      See identical proteins and their annotated locations for XP_011520885.1

      UniProtKB/TrEMBL
      A0A067ZWN6
      Conserved Domains (2) summary
      pfam06409
      Location:70 → 262
      NPIP; Nuclear pore complex interacting protein (NPIP)
      cl17068
      Location:1 → 41
      AFD_class_I; Adenylate forming domain, Class I superfamily

    3. XM_011522584.3 → XP_011520886.1  nuclear pore complex-interacting protein family member A3 isoform X7

      See identical proteins and their annotated locations for XP_011520886.1

      UniProtKB/TrEMBL
      A0A067ZWN6
      Conserved Domains (2) summary
      pfam06409
      Location:70 → 266
      NPIP; Nuclear pore complex interacting protein (NPIP)
      cl17068
      Location:1 → 41
      AFD_class_I; Adenylate forming domain, Class I superfamily

    4. XM_047434470.1 → XP_047290426.1  nuclear pore complex-interacting protein family member A3 isoform X6

    5. XM_011522581.2 → XP_011520883.1  nuclear pore complex-interacting protein family member A3 isoform X6

      See identical proteins and their annotated locations for XP_011520883.1

      UniProtKB/TrEMBL
      A0A067ZWN6
      Conserved Domains (2) summary
      pfam06409
      Location:70 → 262
      NPIP; Nuclear pore complex interacting protein (NPIP)
      cl17068
      Location:1 → 41
      AFD_class_I; Adenylate forming domain, Class I superfamily

    6. XM_047434468.1 → XP_047290424.1  nuclear pore complex-interacting protein family member A3 isoform X4

      UniProtKB/Swiss-Prot
      F8WFD2
      Related
      ENSP00000448841.1, ENST00000552140.6

    7. XM_005255485.4 → XP_005255542.1  nuclear pore complex-interacting protein family member A3 isoform X9

      See identical proteins and their annotated locations for XP_005255542.1

      UniProtKB/TrEMBL
      A0A067ZVG2, A0A067ZWN8, O15103
      Conserved Domains (1) summary
      pfam06409
      Location:22 → 214
      NPIP; Nuclear pore complex interacting protein (NPIP)

    8. XM_047434469.1 → XP_047290425.1  nuclear pore complex-interacting protein family member A3 isoform X5

    9. XM_011522578.3 → XP_011520880.2  nuclear pore complex-interacting protein family member A3 isoform X2

      UniProtKB/TrEMBL
      A0A067ZUL9

    10. XM_011522580.3 → XP_011520882.2  nuclear pore complex-interacting protein family member A3 isoform X3

      UniProtKB/TrEMBL
      A0A067ZUL9

    11. XM_011522585.1 → XP_011520887.1  nuclear pore complex-interacting protein family member A3 isoform X8

      See identical proteins and their annotated locations for XP_011520887.1

      UniProtKB/TrEMBL
      H0YED6
      Conserved Domains (1) summary
      pfam06409
      Location:26 → 245
      NPIP; Nuclear pore complex interacting protein (NPIP)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187607.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      276273..299205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329128.1 → XP_054185103.1  nuclear pore complex-interacting protein family member A3 isoform X10

      UniProtKB/Swiss-Prot
      E9PIF3

    2. XM_054329127.1 → XP_054185102.1  nuclear pore complex-interacting protein family member A3 isoform X10

      UniProtKB/Swiss-Prot
      E9PIF3

    3. XM_054329125.1 → XP_054185100.1  nuclear pore complex-interacting protein family member A3 isoform X1

    4. XM_054329123.1 → XP_054185098.1  nuclear pore complex-interacting protein family member A3 isoform X1

    5. XM_054329134.1 → XP_054185109.1  nuclear pore complex-interacting protein family member A3 isoform X6

    6. XM_054329135.1 → XP_054185110.1  nuclear pore complex-interacting protein family member A3 isoform X7

    7. XM_054329133.1 → XP_054185108.1  nuclear pore complex-interacting protein family member A3 isoform X6

    8. XM_054329132.1 → XP_054185107.1  nuclear pore complex-interacting protein family member A3 isoform X6

    9. XM_054329124.1 → XP_054185099.1  nuclear pore complex-interacting protein family member A3 isoform X1

    10. XM_054329130.1 → XP_054185105.1  nuclear pore complex-interacting protein family member A3 isoform X4

      UniProtKB/TrEMBL
      A0A0B4J2F6

    11. XM_054329137.1 → XP_054185112.1  nuclear pore complex-interacting protein family member A3 isoform X9

      UniProtKB/TrEMBL
      O15103

    12. XM_054329126.1 → XP_054185101.1  nuclear pore complex-interacting protein family member A3 isoform X2

    13. XM_054329131.1 → XP_054185106.1  nuclear pore complex-interacting protein family member A3 isoform X5

    14. XM_054329129.1 → XP_054185104.1  nuclear pore complex-interacting protein family member A3 isoform X3

    15. XM_054329136.1 → XP_054185111.1  nuclear pore complex-interacting protein family member A3 isoform X8

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F8WFD2.1 GenPept UniProtKB/Swiss-Prot:F8WFD2

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