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    ADCK5 aarF domain containing kinase 5 [ Homo sapiens (human) ]

    Gene ID: 203054, updated on 27-Nov-2024

    Summary

    Official Symbol
    ADCK5provided by HGNC
    Official Full Name
    aarF domain containing kinase 5provided by HGNC
    Primary source
    HGNC:HGNC:21738
    See related
    Ensembl:ENSG00000173137 AllianceGenome:HGNC:21738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in phosphorylation. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in duodenum (RPKM 5.3), small intestine (RPKM 4.4) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ADCK5 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144373088..144393242)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145542413..145562879)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145597736..145618457)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145583746-145584281 Neighboring gene solute carrier family 52 member 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145589246-145589414 Neighboring gene uncharacterized LOC101928902 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:145593027-145593528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145595436-145595936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145613649-145614150 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145619396-145619557 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145620910-145621123 Neighboring gene cleavage and polyadenylation specific factor 1 Neighboring gene microRNA 939 Neighboring gene microRNA 1234

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    uncharacterized aarF domain-containing protein kinase 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174922.5NP_777582.4  uncharacterized aarF domain-containing protein kinase 5

      See identical proteins and their annotated locations for NP_777582.4

      Status: VALIDATED

      Source sequence(s)
      BC064345, BC101659, HY037845
      Consensus CDS
      CCDS34965.2
      UniProtKB/Swiss-Prot
      B3KS46, Q3MIX3, Q5U4P1, Q6P2S4, Q8N5V3
      Related
      ENSP00000310547.6, ENST00000308860.11
      Conserved Domains (1) summary
      cd13969
      Location:169409
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      144373088..144393242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013174.2XP_016868663.1  uncharacterized aarF domain-containing protein kinase 5 isoform X2

      Conserved Domains (2) summary
      COG0661
      Location:61341
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13969
      Location:102342
      ADCK1-like; aarF domain containing kinase 1 and similar proteins
    2. XM_011516907.4XP_011515209.1  uncharacterized aarF domain-containing protein kinase 5 isoform X1

      Conserved Domains (2) summary
      COG0661
      Location:202482
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13969
      Location:243483
      ADCK1-like; aarF domain containing kinase 1 and similar proteins
    3. XM_047421456.1XP_047277412.1  uncharacterized aarF domain-containing protein kinase 5 isoform X3

    4. XM_011516909.2XP_011515211.1  uncharacterized aarF domain-containing protein kinase 5 isoform X2

      See identical proteins and their annotated locations for XP_011515211.1

      Conserved Domains (2) summary
      COG0661
      Location:61341
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13969
      Location:102342
      ADCK1-like; aarF domain containing kinase 1 and similar proteins
    5. XM_011516910.2XP_011515212.1  uncharacterized aarF domain-containing protein kinase 5 isoform X4

      See identical proteins and their annotated locations for XP_011515212.1

      Conserved Domains (2) summary
      COG0661
      Location:6301
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13969
      Location:62302
      ADCK1-like; aarF domain containing kinase 1 and similar proteins
    6. XM_006716527.3XP_006716590.1  uncharacterized aarF domain-containing protein kinase 5 isoform X4

      See identical proteins and their annotated locations for XP_006716590.1

      Conserved Domains (2) summary
      COG0661
      Location:6301
      AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
      cd13969
      Location:62302
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654716.1 Reference GRCh38.p14 PATCHES

      Range
      104365..123845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332186.1XP_054188161.1  uncharacterized aarF domain-containing protein kinase 5 isoform X2

    2. XM_054332181.1XP_054188156.1  uncharacterized aarF domain-containing protein kinase 5 isoform X1

    3. XM_054332183.1XP_054188158.1  uncharacterized aarF domain-containing protein kinase 5 isoform X3

    4. XM_054332182.1XP_054188157.1  uncharacterized aarF domain-containing protein kinase 5 isoform X2

    5. XM_054332185.1XP_054188160.1  uncharacterized aarF domain-containing protein kinase 5 isoform X4

    6. XM_054332184.1XP_054188159.1  uncharacterized aarF domain-containing protein kinase 5 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      145542413..145562879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359953.1XP_054215928.1  uncharacterized aarF domain-containing protein kinase 5 isoform X6

    2. XM_054359948.1XP_054215923.1  uncharacterized aarF domain-containing protein kinase 5 isoform X5

    3. XM_054359950.1XP_054215925.1  uncharacterized aarF domain-containing protein kinase 5 isoform X3

    4. XM_054359949.1XP_054215924.1  uncharacterized aarF domain-containing protein kinase 5 isoform X6

    5. XM_054359952.1XP_054215927.1  uncharacterized aarF domain-containing protein kinase 5 isoform X7

    6. XM_054359951.1XP_054215926.1  uncharacterized aarF domain-containing protein kinase 5 isoform X7