U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    MXRA8 matrix remodeling associated 8 [ Homo sapiens (human) ]

    Gene ID: 54587, updated on 27-Nov-2024

    Summary

    Official Symbol
    MXRA8provided by HGNC
    Official Full Name
    matrix remodeling associated 8provided by HGNC
    Primary source
    HGNC:HGNC:7542
    See related
    Ensembl:ENSG00000162576 MIM:617293; AllianceGenome:HGNC:7542
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASP3
    Summary
    Predicted to be involved in establishment of glial blood-brain barrier. Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in gall bladder (RPKM 26.7), fat (RPKM 25.8) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MXRA8 in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1352689..1363541, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (783235..794097, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1288069..1298921, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene taste 1 receptor member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 61 Neighboring gene dishevelled segment polarity protein 1 Neighboring gene microRNA 6808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1281421-1282299 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1282501-1283130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1283131-1283760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 62 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 63 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 64 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1288877-1289508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1289509-1290140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1290141-1290771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1291896-1292448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1293036-1293618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 65 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 66 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1307318-1308085 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 67 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1310373-1311278 Neighboring gene aurora kinase A interacting protein 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC3047, DKFZp586E2023

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of glial blood-brain barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in ciliary membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    matrix remodeling-associated protein 8
    Names
    limitrin
    matrix-remodeling-associated protein 8
    matrix-remodelling associated 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282582.2NP_001269511.1  matrix remodeling-associated protein 8 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001269511.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in both UTRs and uses an alternate splice site in the 3' terminal exon compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. Variants 2 and 5 encode the same isoform (2).
      Source sequence(s)
      AL139287
      Consensus CDS
      CCDS24.1
      UniProtKB/Swiss-Prot
      B3KTR6, B4DE34, Q5TA39, Q96KC3, Q9BRK3
      Conserved Domains (1) summary
      pfam07686
      Location:172291
      V-set; Immunoglobulin V-set domain
    2. NM_001282583.2NP_001269512.1  matrix remodeling-associated protein 8 isoform 4

      See identical proteins and their annotated locations for NP_001269512.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in both UTRs and has multiple coding region differences compared to variant 1. The encoded isoform (4) is shorter and has distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AL139287
      Consensus CDS
      CCDS59952.1
      Related
      ENSP00000436135.1, ENST00000477278.3
      Conserved Domains (1) summary
      pfam07686
      Location:163282
      V-set; Immunoglobulin V-set domain
    3. NM_001282584.2NP_001269513.1  matrix remodeling-associated protein 8 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001269513.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in both UTRs and has multiple coding region differences compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL139287
      Consensus CDS
      CCDS59950.1
      UniProtKB/Swiss-Prot
      Q9BRK3
      Related
      ENSP00000344998.4, ENST00000342753.8
      Conserved Domains (1) summary
      pfam07686
      Location:71190
      V-set; Immunoglobulin V-set domain
    4. NM_001282585.1NP_001269514.1  matrix remodeling-associated protein 8 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK027269, AL139287, DC356331
      Consensus CDS
      CCDS59951.1
      Related
      ENSP00000399229.2, ENST00000445648.5
      Conserved Domains (1) summary
      pfam07686
      Location:172291
      V-set; Immunoglobulin V-set domain
    5. NM_032348.4NP_115724.1  matrix remodeling-associated protein 8 isoform 2 precursor

      See identical proteins and their annotated locations for NP_115724.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in both UTRs and uses two alternate splice sites in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. Variants 2 and 5 encode the same isoform (2).
      Source sequence(s)
      AL139287
      Consensus CDS
      CCDS24.1
      UniProtKB/Swiss-Prot
      B3KTR6, B4DE34, Q5TA39, Q96KC3, Q9BRK3
      Related
      ENSP00000307887.6, ENST00000309212.11
      Conserved Domains (1) summary
      pfam07686
      Location:172291
      V-set; Immunoglobulin V-set domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      1352689..1363541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001517.2XP_016857006.1  matrix remodeling-associated protein 8 isoform X2

    2. XM_017001516.3XP_016857005.1  matrix remodeling-associated protein 8 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      783235..794097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337161.1XP_054193136.1  matrix remodeling-associated protein 8 isoform X2

    2. XM_054337160.1XP_054193135.1  matrix remodeling-associated protein 8 isoform X1