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    KIF17 kinesin family member 17 [ Homo sapiens (human) ]

    Gene ID: 57576, updated on 27-Nov-2024

    Summary

    Official Symbol
    KIF17provided by HGNC
    Official Full Name
    kinesin family member 17provided by HGNC
    Primary source
    HGNC:HGNC:19167
    See related
    Ensembl:ENSG00000117245 MIM:605037; AllianceGenome:HGNC:19167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIF3X; KLP-2; OSM-3; KIF17B
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in anterograde dendritic transport of neurotransmitter receptor complex and cell projection organization. Predicted to act upstream of or within microtubule-based process; protein-containing complex localization; and vesicle-mediated transport. Predicted to be located in cytosol. Predicted to be part of kinesin complex. Predicted to be active in several cellular components, including cilium; microtubule cytoskeleton; and postsynapse. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis (RPKM 11.7), spleen (RPKM 7.5) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See KIF17 in Genome Data Viewer
    Location:
    1p36.12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (20661630..20718007, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (20487429..20544577, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20990507..21044500, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 6084 Neighboring gene PTEN induced kinase 1 Neighboring gene PINK1 antisense RNA Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:20987241-20988160 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:20988161-20989080 Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21011543-21012044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21015049-21015549 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:21015960-21016182 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21036574-21037228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 369 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 370 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21054065-21054727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21054728-21055389 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21056983-21057676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21057677-21058368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21058590-21059262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21059263-21059933 Neighboring gene SH2 domain containing 5 Neighboring gene heterochromatin protein 1 binding protein 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:21112523-21112715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 375 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 376

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of kinesin family member 17 (KIF17) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The gene expression of kinesin family member 17 is significantly upregulated in clade B treated SK-N-MC neuroblastoma cells but downregulated in clade C Tat treated SK-N-MC neuroblastoma cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1405

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in anterograde dendritic transport of neurotransmitter receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell projection organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axoneme IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cilium TAS
    Traceable Author Statement
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in periciliary membrane compartment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in photoreceptor connecting cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in photoreceptor inner segment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in photoreceptor outer segment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    kinesin-like protein KIF17
    Names
    KIF17 variant protein
    KIF3-related motor protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122819.3NP_001116291.1  kinesin-like protein KIF17 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
      Source sequence(s)
      AL663074, AY484427, BC040639, BC065927, BX387401
      Consensus CDS
      CCDS44079.1
      UniProtKB/TrEMBL
      B0I1R5
      Related
      ENSP00000383311.3, ENST00000400463.8
      Conserved Domains (2) summary
      cl22853
      Location:4335
      Motor_domain; Myosin and Kinesin motor domain
      pfam00225
      Location:11335
      Kinesin; Kinesin motor domain
    2. NM_001287212.2NP_001274141.1  kinesin-like protein KIF17 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AB037826, AL663074, AY484427, BC040639, BC065927, BX387401
      Consensus CDS
      CCDS72722.1
      UniProtKB/TrEMBL
      A0A0A0MRS8, B0I1R5
      Related
      ENSP00000364184.1, ENST00000375044.5
      Conserved Domains (2) summary
      cl22853
      Location:1235
      Motor_domain; Myosin and Kinesin motor domain
      pfam00225
      Location:1235
      Kinesin; Kinesin motor domain
    3. NM_020816.4NP_065867.2  kinesin-like protein KIF17 isoform a

      See identical proteins and their annotated locations for NP_065867.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AL663074, AY484427, BC040639, BC065927, BX387401
      Consensus CDS
      CCDS213.1
      UniProtKB/Swiss-Prot
      A2A3Q7, A2A3Q8, O95077, Q53YS6, Q5VWA9, Q6GSA8, Q8N411, Q9P2E2
      UniProtKB/TrEMBL
      B0I1R5
      Related
      ENSP00000247986.2, ENST00000247986.2
      Conserved Domains (2) summary
      cl22853
      Location:4335
      Motor_domain; Myosin and Kinesin motor domain
      pfam00225
      Location:11335
      Kinesin; Kinesin motor domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      20661630..20718007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426155.1XP_047282111.1  kinesin-like protein KIF17 isoform X10

    2. XM_047426150.1XP_047282106.1  kinesin-like protein KIF17 isoform X5

    3. XM_047426154.1XP_047282110.1  kinesin-like protein KIF17 isoform X9

    4. XM_047426149.1XP_047282105.1  kinesin-like protein KIF17 isoform X4

    5. XM_047426153.1XP_047282109.1  kinesin-like protein KIF17 isoform X8

    6. XM_047426148.1XP_047282104.1  kinesin-like protein KIF17 isoform X3

    7. XM_047426147.1XP_047282103.1  kinesin-like protein KIF17 isoform X2

    8. XM_047426152.1XP_047282108.1  kinesin-like protein KIF17 isoform X7

    9. XM_047426146.1XP_047282102.1  kinesin-like protein KIF17 isoform X1

    10. XM_047426157.1XP_047282113.1  kinesin-like protein KIF17 isoform X12

    11. XM_047426156.1XP_047282112.1  kinesin-like protein KIF17 isoform X11

    12. XM_047426151.1XP_047282107.1  kinesin-like protein KIF17 isoform X6

    13. XM_047426158.1XP_047282114.1  kinesin-like protein KIF17 isoform X13

    14. XM_047426160.1XP_047282116.1  kinesin-like protein KIF17 isoform X15

    15. XM_047426159.1XP_047282115.1  kinesin-like protein KIF17 isoform X14

    16. XM_047426161.1XP_047282117.1  kinesin-like protein KIF17 isoform X16

    RNA

    1. XR_007062426.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      20487429..20544577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337847.1XP_054193822.1  kinesin-like protein KIF17 isoform X10

    2. XM_054337845.1XP_054193820.1  kinesin-like protein KIF17 isoform X8

    3. XM_054337841.1XP_054193816.1  kinesin-like protein KIF17 isoform X4

    4. XM_054337842.1XP_054193817.1  kinesin-like protein KIF17 isoform X5

    5. XM_054337846.1XP_054193821.1  kinesin-like protein KIF17 isoform X9

    6. XM_054337840.1XP_054193815.1  kinesin-like protein KIF17 isoform X3

    7. XM_054337839.1XP_054193814.1  kinesin-like protein KIF17 isoform X2

    8. XM_054337844.1XP_054193819.1  kinesin-like protein KIF17 isoform X7

    9. XM_054337838.1XP_054193813.1  kinesin-like protein KIF17 isoform X1

    10. XM_054337849.1XP_054193824.1  kinesin-like protein KIF17 isoform X12

    11. XM_054337848.1XP_054193823.1  kinesin-like protein KIF17 isoform X11

    12. XM_054337843.1XP_054193818.1  kinesin-like protein KIF17 isoform X6

    13. XM_054337850.1XP_054193825.1  kinesin-like protein KIF17 isoform X13

    14. XM_054337852.1XP_054193827.1  kinesin-like protein KIF17 isoform X15

    15. XM_054337851.1XP_054193826.1  kinesin-like protein KIF17 isoform X14

    16. XM_054337853.1XP_054193828.1  kinesin-like protein KIF17 isoform X16

    RNA

    1. XR_008486120.1 RNA Sequence