SETDB1 SET domain bifurcated histone lysine methyltransferase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SETDB1provided by HGNC
Official Full Name: SET domain bifurcated histone lysine methyltransferase 1provided by HGNC
Primary source: HGNC:HGNC:10761
See related: Ensembl:ENSG00000143379 MIM:604396; AllianceGenome:HGNC:10761
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ESET; KG1T; KMT1E; TDRD21; H3-K9-HMTase4
Summary: This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]
Expression: Ubiquitous expression in testis (RPKM 14.6), spleen (RPKM 8.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q21.3

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (150926263..150964737)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (150049948..150088436)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (150898739..150937213)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SETDB1 targeting SESN2 regulates mitochondrial damage and oxidative stress in renal ischemia-reperfusion injury.
Title: SETDB1 targeting SESN2 regulates mitochondrial damage and oxidative stress in renal ischemia-reperfusion injury.
SETDB1 deletion causes DNA demethylation and upregulation of multiple zinc-finger genes.
Title: SETDB1 deletion causes DNA demethylation and upregulation of multiple zinc-finger genes.
[Downregulation of SETDB1 suppresses epithelial mesenchymal transition and invasion and metastasis in oral cancer via SOX7 methylation].
Title: [Downregulation of SETDB1 suppresses epithelial mesenchymal transition and invasion and metastasis in oral cancer via SOX7 methylation].
Structural evidence for protein-protein interaction between the non-canonical methyl-CpG-binding domain of SETDB proteins and C11orf46.
Title: Structural evidence for protein-protein interaction between the non-canonical methyl-CpG-binding domain of SETDB proteins and C11orf46.
SETDB1 promotes progression through upregulation of SF3B4 expression and regulates the immunity in ovarian cancer.
Title: SETDB1 promotes progression through upregulation of SF3B4 expression and regulates the immunity in ovarian cancer.
Cytoplasmic localization of SETDB1-induced Warburg effect via c-MYC-LDHA axis enhances migration and invasion in breast carcinoma.
Title: Cytoplasmic localization of SETDB1‑induced Warburg effect via c‑MYC‑LDHA axis enhances migration and invasion in breast carcinoma.
Hyperglycaemia aggravates periodontal inflamm-aging by promoting SETDB1-mediated LINE-1 de-repression in macrophages.
Title: Hyperglycaemia aggravates periodontal inflamm-aging by promoting SETDB1-mediated LINE-1 de-repression in macrophages.
[Histone methyltransferases and regenerative myogenesis: A focus on SETDB1].
Title: [Histone methyltransferases and regenerative myogenesis: A focus on SETDB1].
Evidence of a synthetic lethality interaction between SETDB1 histone methyltransferase and CHD4 chromatin remodeling protein in a triple negative breast cancer cell line.
Title: Evidence of a synthetic lethality interaction between SETDB1 histone methyltransferase and CHD4 chromatin remodeling protein in a triple negative breast cancer cell line.
SETDB1: A perspective into immune cell function and cancer immunotherapy.
Title: SETDB1: A perspective into immune cell function and cancer immunotherapy.

Submit: New GeneRIF Correction See all GeneRIFs (101)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3. EBI GWAS Catalog EBI GWAS CatalogPubMed
New loci associated with kidney function and chronic kidney disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of SET domain, bifurcated 1 (SETDB1) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat associates with and is methylated at lysine's 50 and 51 by SETDB1. SETDB1 knockdown increases the transactivation of the HIV-1 LTR	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH12118 (e-PCR)
- UniSTS:51212

RH68265 (e-PCR)
- UniSTS:76837

D1S2372 (e-PCR)
- UniSTS:64049

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-2406 (e-PCR)
- UniSTS:6996

Cda0kh05 (e-PCR)
- UniSTS:34430

D1S3444 (e-PCR)
- UniSTS:51613

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H3 methyltransferase activity	TAS Traceable Author Statement more info
enables histone H3K9 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K9 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K9 monomethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 trimethyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K9me2 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA methylation-dependent constitutive heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in transposable element silencing by heterochromatin formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in transposable element silencing by heterochromatin formation	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: histone-lysine N-methyltransferase SETDB1

Names: ERG-associated protein with a SET domain, ESET; SET domain bifurcated 1; histone H3-K9 methyltransferase 4; histone-lysine N-methyltransferase, H3lysine-9 specific 4; lysine N-methyltransferase 1E; tudor domain containing 21

NP_001138887.1

EC 2.1.1.366

NP_001230420.1

EC 2.1.1.366

NP_001353346.1

EC 2.1.1.366

NP_001353347.1

EC 2.1.1.366

NP_001380887.1

EC 2.1.1.366

NP_001380888.1

EC 2.1.1.366

NP_001380889.1

EC 2.1.1.366

NP_001380890.1

EC 2.1.1.366

NP_001380893.1

EC 2.1.1.366

NP_001380894.1

EC 2.1.1.366

NP_001380895.1

EC 2.1.1.366

NP_001380896.1

EC 2.1.1.366

NP_001380897.1

EC 2.1.1.366

NP_036564.3

EC 2.1.1.366

XP_047291523.1

EC 2.1.1.366

XP_047291529.1

EC 2.1.1.366

XP_047291535.1

EC 2.1.1.366

XP_047291538.1

EC 2.1.1.366

XP_047291542.1

EC 2.1.1.366

XP_047291543.1

EC 2.1.1.366

XP_054195850.1

EC 2.1.1.366

XP_054195851.1

EC 2.1.1.366

XP_054195852.1

EC 2.1.1.366

XP_054195853.1

EC 2.1.1.366

XP_054195854.1

EC 2.1.1.366

XP_054195855.1

EC 2.1.1.366

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145415.2 → NP_001138887.1 histone-lysine N-methyltransferase SETDB1 isoform 1

See identical proteins and their annotated locations for NP_001138887.1

Status: REVIEWED

Source sequence(s)

AI582266, D31891, DA418593

Consensus CDS

CCDS44217.1

UniProtKB/Swiss-Prot

A6NEW2, Q15047, Q5SZD8, Q5SZD9, Q5SZE0, Q5SZE7, Q96GM9

UniProtKB/TrEMBL

E9PRF4

Related

ENSP00000271640.5, ENST00000271640.9

Conserved Domains (6) summary

smart00391
Location:597 → 672

MBD; Methyl-CpG binding domain

cd10517
Location:674 → 875

SET_SETDB1; SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins

cl40432
Location:1202 → 1291

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

pfam18300
Location:193 → 250

DUF5604; Domain of unknown function (DUF5604)

cd20382
Location:260 → 341

Tudor_SETDB1_rpt1; first Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins

cd21181
Location:348 → 401

Tudor_SETDB1_rpt2; second Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins
NM_001243491.2 → NP_001230420.1 histone-lysine N-methyltransferase SETDB1 isoform 3

See identical proteins and their annotated locations for NP_001230420.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, differs in the 3' UTR and lacks a large portion of the coding region, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus and lacks the histone methyltransferase and SET domains, compared to isoform 1. Variants 3 and 10-12 all encode the same isoform (3).

Source sequence(s)

BC009362, DA418593

Consensus CDS

CCDS58026.1

UniProtKB/Swiss-Prot

Q15047

Related

ENSP00000357958.2, ENST00000368962.6

Conserved Domains (3) summary

pfam18300
Location:193 → 250

DUF5604; Domain of unknown function (DUF5604)

cd20382
Location:260 → 341

Tudor_SETDB1_rpt1; first Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins

cl02573
Location:348 → 380

Tudor_SF; Tudor domain superfamily
NM_001366417.1 → NP_001353346.1 histone-lysine N-methyltransferase SETDB1 isoform 4

Status: REVIEWED

Source sequence(s)

AL590133

Consensus CDS

CCDS91050.1

UniProtKB/TrEMBL

A0A8I5KT93, E9PRF4

Related

ENSP00000508664.1, ENST00000692314.1

Conserved Domains (6) summary

smart00391
Location:598 → 673

MBD; Methyl-CpG binding domain

cd10517
Location:675 → 876

SET_SETDB1; SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins

cl40432
Location:1203 → 1292

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

pfam18300
Location:193 → 250

DUF5604; Domain of unknown function (DUF5604)

cd20382
Location:260 → 341

Tudor_SETDB1_rpt1; first Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins

cd21181
Location:348 → 401

Tudor_SETDB1_rpt2; second Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins
NM_001366418.1 → NP_001353347.1 histone-lysine N-methyltransferase SETDB1 isoform 4

Status: REVIEWED

Source sequence(s)

AL590133

Consensus CDS

CCDS91050.1

UniProtKB/TrEMBL

A0A8I5KT93, E9PRF4

Related

ENSP00000509425.1, ENST00000692827.1

Conserved Domains (6) summary

smart00391
Location:598 → 673

MBD; Methyl-CpG binding domain

cd10517
Location:675 → 876

SET_SETDB1; SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins

cl40432
Location:1203 → 1292

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

pfam18300
Location:193 → 250

DUF5604; Domain of unknown function (DUF5604)

cd20382
Location:260 → 341

Tudor_SETDB1_rpt1; first Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins

cd21181
Location:348 → 401

Tudor_SETDB1_rpt2; second Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins
NM_001393958.1 → NP_001380887.1 histone-lysine N-methyltransferase SETDB1 isoform 4

Status: REVIEWED

Source sequence(s)

AL590133

Consensus CDS

CCDS91050.1

UniProtKB/TrEMBL

A0A8I5KT93, E9PRF4

Conserved Domains (6) summary

smart00391
Location:598 → 673

MBD; Methyl-CpG binding domain

cd10517
Location:675 → 876

SET_SETDB1; SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins

cl40432
Location:1203 → 1292

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

pfam18300
Location:193 → 250

DUF5604; Domain of unknown function (DUF5604)

cd20382
Location:260 → 341

Tudor_SETDB1_rpt1; first Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins

cd21181
Location:348 → 401

Tudor_SETDB1_rpt2; second Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins
NM_001393959.1 → NP_001380888.1 histone-lysine N-methyltransferase SETDB1 isoform 4

Status: REVIEWED

Source sequence(s)

AL590133

Consensus CDS

CCDS91050.1

UniProtKB/TrEMBL

A0A8I5KT93, E9PRF4

Conserved Domains (6) summary

smart00391
Location:598 → 673

MBD; Methyl-CpG binding domain

cd10517
Location:675 → 876

SET_SETDB1; SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins

cl40432
Location:1203 → 1292

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

pfam18300
Location:193 → 250

DUF5604; Domain of unknown function (DUF5604)

cd20382
Location:260 → 341

Tudor_SETDB1_rpt1; first Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins

cd21181
Location:348 → 401

Tudor_SETDB1_rpt2; second Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins
NM_001393960.1 → NP_001380889.1 histone-lysine N-methyltransferase SETDB1 isoform 1

Status: REVIEWED

Source sequence(s)

AL590133

Consensus CDS

CCDS44217.1

UniProtKB/Swiss-Prot

A6NEW2, Q15047, Q5SZD8, Q5SZD9, Q5SZE0, Q5SZE7, Q96GM9

UniProtKB/TrEMBL

E9PRF4

Conserved Domains (6) summary

smart00391
Location:597 → 672

MBD; Methyl-CpG binding domain

cd10517
Location:674 → 875

SET_SETDB1; SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins

cl40432
Location:1202 → 1291

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

pfam18300
Location:193 → 250

DUF5604; Domain of unknown function (DUF5604)

cd20382
Location:260 → 341

Tudor_SETDB1_rpt1; first Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins

cd21181
Location:348 → 401

Tudor_SETDB1_rpt2; second Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins
NM_001393961.1 → NP_001380890.1 histone-lysine N-methyltransferase SETDB1 isoform 5

Status: REVIEWED

Source sequence(s)

AL590133

UniProtKB/TrEMBL

E9PRF4

Conserved Domains (4) summary

smart00391
Location:598 → 673

MBD; Methyl-CpG binding domain

smart00333
Location:348 → 400

TUDOR; Tudor domain

cd10517
Location:675 → 876

SET_SETDB1; SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins

cl40432
Location:1203 → 1291

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
NM_001393964.1 → NP_001380893.1 histone-lysine N-methyltransferase SETDB1 isoform 3

Status: REVIEWED

Source sequence(s)

AL590133

Consensus CDS

CCDS58026.1

Conserved Domains (3) summary

pfam18300
Location:193 → 250

DUF5604; Domain of unknown function (DUF5604)

cd20382
Location:260 → 341

Tudor_SETDB1_rpt1; first Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins

cl02573
Location:348 → 380

Tudor_SF; Tudor domain superfamily
NM_001393965.1 → NP_001380894.1 histone-lysine N-methyltransferase SETDB1 isoform 3

Status: REVIEWED

Source sequence(s)

AL590133

Consensus CDS

CCDS58026.1

Conserved Domains (3) summary

pfam18300
Location:193 → 250

DUF5604; Domain of unknown function (DUF5604)

cd20382
Location:260 → 341

Tudor_SETDB1_rpt1; first Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins

cl02573
Location:348 → 380

Tudor_SF; Tudor domain superfamily
NM_001393966.1 → NP_001380895.1 histone-lysine N-methyltransferase SETDB1 isoform 3

Status: REVIEWED

Source sequence(s)

AL590133

Consensus CDS

CCDS58026.1

Conserved Domains (3) summary

pfam18300
Location:193 → 250

DUF5604; Domain of unknown function (DUF5604)

cd20382
Location:260 → 341

Tudor_SETDB1_rpt1; first Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins

cl02573
Location:348 → 380

Tudor_SF; Tudor domain superfamily
NM_001393967.1 → NP_001380896.1 histone-lysine N-methyltransferase SETDB1 isoform 6

Status: REVIEWED

Source sequence(s)

AL590133

Consensus CDS

CCDS91051.1

UniProtKB/TrEMBL

X6R732

Related

ENSP00000357959.1, ENST00000368963.5

Conserved Domains (1) summary

pfam18300
Location:193 → 225

DUF5604; Domain of unknown function (DUF5604)
NM_001393968.1 → NP_001380897.1 histone-lysine N-methyltransferase SETDB1 isoform 6

Status: REVIEWED

Source sequence(s)

AL590133

Consensus CDS

CCDS91051.1

UniProtKB/TrEMBL

X6R732

Conserved Domains (1) summary

pfam18300
Location:193 → 225

DUF5604; Domain of unknown function (DUF5604)
NM_012432.4 → NP_036564.3 histone-lysine N-methyltransferase SETDB1 isoform 2

See identical proteins and their annotated locations for NP_036564.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.

Source sequence(s)

BC028671, D31891, DA418593

Consensus CDS

CCDS972.1

UniProtKB/TrEMBL

E9PRF4

Related

ENSP00000357965.4, ENST00000368969.8

Conserved Domains (4) summary

smart00391
Location:597 → 672

MBD; Methyl-CpG binding domain

smart00468
Location:679 → 786

PreSET; N-terminal to some SET domains

smart00333
Location:348 → 400

TUDOR; Tudor domain

smart00317
Location:1206 → 1267

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

RNA

NR_172060.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL590133

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

150926263..150964737

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047435582.1 → XP_047291538.1 histone-lysine N-methyltransferase SETDB1 isoform X2

UniProtKB/Swiss-Prot

A6NEW2, Q15047, Q5SZD8, Q5SZD9, Q5SZE0, Q5SZE7, Q96GM9

UniProtKB/TrEMBL

E9PRF4

Related

ENSP00000432348.1, ENST00000498193.5
XM_047435567.1 → XP_047291523.1 histone-lysine N-methyltransferase SETDB1 isoform X1

UniProtKB/TrEMBL

A0A8I5KT93, E9PRF4
XM_047435579.1 → XP_047291535.1 histone-lysine N-methyltransferase SETDB1 isoform X2

UniProtKB/Swiss-Prot

A6NEW2, Q15047, Q5SZD8, Q5SZD9, Q5SZE0, Q5SZE7, Q96GM9

UniProtKB/TrEMBL

E9PRF4
XM_047435573.1 → XP_047291529.1 histone-lysine N-methyltransferase SETDB1 isoform X2

UniProtKB/Swiss-Prot

A6NEW2, Q15047, Q5SZD8, Q5SZD9, Q5SZE0, Q5SZE7, Q96GM9

UniProtKB/TrEMBL

E9PRF4
XM_047435587.1 → XP_047291543.1 histone-lysine N-methyltransferase SETDB1 isoform X4

UniProtKB/TrEMBL

E9PQM8

Related

ENSP00000436148.1, ENST00000534805.5
XM_047435586.1 → XP_047291542.1 histone-lysine N-methyltransferase SETDB1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

150049948..150088436

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054339878.1 → XP_054195853.1 histone-lysine N-methyltransferase SETDB1 isoform X2

UniProtKB/Swiss-Prot

A6NEW2, Q15047, Q5SZD8, Q5SZD9, Q5SZE0, Q5SZE7, Q96GM9

UniProtKB/TrEMBL

E9PRF4
XM_054339875.1 → XP_054195850.1 histone-lysine N-methyltransferase SETDB1 isoform X1

UniProtKB/TrEMBL

A0A8I5KT93, E9PRF4
XM_054339877.1 → XP_054195852.1 histone-lysine N-methyltransferase SETDB1 isoform X2

UniProtKB/Swiss-Prot

A6NEW2, Q15047, Q5SZD8, Q5SZD9, Q5SZE0, Q5SZE7, Q96GM9

UniProtKB/TrEMBL

E9PRF4
XM_054339876.1 → XP_054195851.1 histone-lysine N-methyltransferase SETDB1 isoform X2

UniProtKB/Swiss-Prot

A6NEW2, Q15047, Q5SZD8, Q5SZD9, Q5SZE0, Q5SZE7, Q96GM9

UniProtKB/TrEMBL

E9PRF4
XM_054339880.1 → XP_054195855.1 histone-lysine N-methyltransferase SETDB1 isoform X4

UniProtKB/TrEMBL

E9PQM8
XM_054339879.1 → XP_054195854.1 histone-lysine N-methyltransferase SETDB1 isoform X3