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    ZDHHC16 zinc finger DHHC-type palmitoyltransferase 16 [ Homo sapiens (human) ]

    Gene ID: 84287, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZDHHC16provided by HGNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 16provided by HGNC
    Primary source
    HGNC:HGNC:20714
    See related
    Ensembl:ENSG00000171307 MIM:616750; AllianceGenome:HGNC:20714
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APH2; DHHC-16
    Summary
    Enables palmitoyltransferase activity. Involved in protein palmitoylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 10.0), lung (RPKM 9.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZDHHC16 in Genome Data Viewer
    Location:
    10q24.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (97446175..97457370)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (98326355..98337553)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99205932..99217127)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr10:99186899-99187121 Neighboring gene phosphoglycerate mutase 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99204892-99205472 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99205473-99206052 Neighboring gene exosome component 1 Neighboring gene MMS19 homolog, cytosolic iron-sulfur assembly component Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99257304-99257834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2680 Neighboring gene ubiquitin domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99277050-99277878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99301395-99302007 Neighboring gene uncharacterized LOC124902488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99302008-99302619 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99311139-99311639 Neighboring gene NANOG hESC enhancer GRCh37_chr10:99313431-99313932

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC2993

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in telencephalon development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    palmitoyltransferase ZDHHC16
    Names
    Abl-philin 2
    probable palmitoyltransferase ZDHHC16
    zinc finger DHHC domain-containing protein 16
    zinc finger DHHC-type containing 16
    zinc finger, DHHC domain containing 16
    NP_001274732.1
    NP_001274733.1
    NP_115703.2
    NP_932160.1
    NP_932161.1
    NP_932162.1
    NP_932163.1
    XP_006718087.1
    XP_016872255.1
    XP_016872256.1
    XP_016872257.1
    XP_016872258.1
    XP_016872260.1
    XP_024304001.1
    XP_047281793.1
    XP_047281794.1
    XP_047281795.1
    XP_047281796.1
    XP_047281797.1
    XP_047281798.1
    XP_054222889.1
    XP_054222890.1
    XP_054222891.1
    XP_054222892.1
    XP_054222893.1
    XP_054222894.1
    XP_054222895.1
    XP_054222896.1
    XP_054222897.1
    XP_054222898.1
    XP_054222899.1
    XP_054222900.1
    XP_054222901.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287803.2NP_001274732.1  palmitoyltransferase ZDHHC16 isoform 5

      See identical proteins and their annotated locations for NP_001274732.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. It encodes isoform 5, which is shorter than isoform 1.
      Source sequence(s)
      AK297962, BC008074, BM678689, DC399731
      UniProtKB/TrEMBL
      B4DNL2, H0Y6E9
      Conserved Domains (1) summary
      pfam01529
      Location:156231
      DHHC; DHHC palmitoyltransferase
    2. NM_001287804.2NP_001274733.1  palmitoyltransferase ZDHHC16 isoform 6

      See identical proteins and their annotated locations for NP_001274733.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks three exons in the central and 3' coding regions and uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. It encodes isoform 6, which is shorter than isoform 1.
      Source sequence(s)
      BC008074, BC033157, BM678689, BX353685
      Consensus CDS
      CCDS73176.1
      UniProtKB/TrEMBL
      B1AMU0
      Related
      ENSP00000359883.4, ENST00000370846.8
      Conserved Domains (1) summary
      cl19890
      Location:156185
      DHHC; DHHC palmitoyltransferase
    3. NM_032327.4NP_115703.2  palmitoyltransferase ZDHHC16 isoform 1

      See identical proteins and their annotated locations for NP_115703.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 5. Variants 1 and 5 encode the same isoform (1), which is the longest isoform.
      Source sequence(s)
      BC012830, BM678689
      Consensus CDS
      CCDS7460.1
      UniProtKB/Swiss-Prot
      D3DR52, D3DR53, D3DR54, Q5JTG7, Q5JTH0, Q8N4Z6, Q8WY84, Q969W1, Q9BSV3
      UniProtKB/TrEMBL
      H0Y6E9
      Related
      ENSP00000359891.3, ENST00000370854.7
      Conserved Domains (1) summary
      pfam01529
      Location:156305
      DHHC; DHHC palmitoyltransferase
    4. NM_198043.3NP_932160.1  palmitoyltransferase ZDHHC16 isoform 2

      See identical proteins and their annotated locations for NP_932160.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 5. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AF258563, BM678689, DC399731
      Consensus CDS
      CCDS7461.1
      UniProtKB/TrEMBL
      H0Y6E9
      Related
      ENSP00000345383.4, ENST00000352634.8
      Conserved Domains (1) summary
      pfam01529
      Location:156289
      DHHC; DHHC palmitoyltransferase
    5. NM_198044.3NP_932161.1  palmitoyltransferase ZDHHC16 isoform 3

      See identical proteins and their annotated locations for NP_932161.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, and lacks an alternate exon and uses an alternate in-frame splice site in the 5' coding region, compared to variant 5. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      BC033157, BM678689, DC399731
      Consensus CDS
      CCDS7462.1
      UniProtKB/TrEMBL
      H0Y6E9
      Related
      ENSP00000323360.3, ENST00000353979.7
      Conserved Domains (1) summary
      cl19890
      Location:126175
      DHHC; DHHC palmitoyltransferase
    6. NM_198045.3NP_932162.1  palmitoyltransferase ZDHHC16 isoform 4

      See identical proteins and their annotated locations for NP_932162.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons, one in the 5' coding region and the other in the 3' coding region, compared to variant 5. It encodes isoform 4, which is shorter than isoform 1.
      Source sequence(s)
      BC004535, DC399731
      Consensus CDS
      CCDS7463.1
      UniProtKB/Swiss-Prot
      Q969W1
      Related
      ENSP00000304487.8, ENST00000345745.9
      Conserved Domains (1) summary
      pfam01529
      Location:91224
      zf-DHHC; DHHC palmitoyltransferase
    7. NM_198046.3NP_932163.1  palmitoyltransferase ZDHHC16 isoform 1

      See identical proteins and their annotated locations for NP_932163.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents the longest transcript. Variants 1 and 5 encode the same isoform (1), which is the longest isoform.
      Source sequence(s)
      AJ294945, AK297962, BM678689, DC399731
      Consensus CDS
      CCDS7460.1
      UniProtKB/Swiss-Prot
      D3DR52, D3DR53, D3DR54, Q5JTG7, Q5JTH0, Q8N4Z6, Q8WY84, Q969W1, Q9BSV3
      UniProtKB/TrEMBL
      H0Y6E9
      Related
      ENSP00000377357.1, ENST00000393760.6
      Conserved Domains (1) summary
      pfam01529
      Location:156305
      DHHC; DHHC palmitoyltransferase

    RNA

    1. NR_109895.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks three internal exons and uses an alternate splice site in an internal exon, compared to variant 5. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 5z.
      Source sequence(s)
      BC004535, BG769550, DC399731

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      97446175..97457370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016766.2XP_016872255.1  palmitoyltransferase ZDHHC16 isoform X1

      UniProtKB/TrEMBL
      H0Y6E9
      Conserved Domains (1) summary
      pfam01529
      Location:156289
      DHHC; DHHC palmitoyltransferase
    2. XM_047425837.1XP_047281793.1  palmitoyltransferase ZDHHC16 isoform X3

      UniProtKB/TrEMBL
      H0Y6E9
    3. XM_017016771.2XP_016872260.1  palmitoyltransferase ZDHHC16 isoform X8

      UniProtKB/TrEMBL
      B1AMU0
      Conserved Domains (1) summary
      cl19890
      Location:156185
      DHHC; DHHC palmitoyltransferase
    4. XM_017016768.2XP_016872257.1  palmitoyltransferase ZDHHC16 isoform X4

      UniProtKB/TrEMBL
      H0Y6E9
      Conserved Domains (1) summary
      cl19890
      Location:126175
      DHHC; DHHC palmitoyltransferase
    5. XM_047425839.1XP_047281795.1  palmitoyltransferase ZDHHC16 isoform X6

      UniProtKB/TrEMBL
      H0Y6E9
    6. XM_047425842.1XP_047281798.1  palmitoyltransferase ZDHHC16 isoform X10

    7. XM_006718024.2XP_006718087.1  palmitoyltransferase ZDHHC16 isoform X2

      See identical proteins and their annotated locations for XP_006718087.1

      UniProtKB/TrEMBL
      B4DNL2, H0Y6E9
      Related
      ENSP00000396286.1, ENST00000417044.1
      Conserved Domains (1) summary
      pfam01529
      Location:156231
      DHHC; DHHC palmitoyltransferase
    8. XM_017016767.2XP_016872256.1  palmitoyltransferase ZDHHC16 isoform X3

      UniProtKB/TrEMBL
      H0Y6E9
      Related
      ENSP00000405240.1, ENST00000420089.5
      Conserved Domains (1) summary
      pfam01529
      Location:156242
      DHHC; DHHC palmitoyltransferase
    9. XM_047425838.1XP_047281794.1  palmitoyltransferase ZDHHC16 isoform X6

      UniProtKB/TrEMBL
      H0Y6E9
    10. XM_017016769.2XP_016872258.1  palmitoyltransferase ZDHHC16 isoform X5

      UniProtKB/TrEMBL
      H0Y6E9
      Conserved Domains (1) summary
      cl19890
      Location:156250
      DHHC; DHHC palmitoyltransferase
    11. XM_024448233.2XP_024304001.1  palmitoyltransferase ZDHHC16 isoform X7

      Conserved Domains (1) summary
      pfam01529
      Location:91240
      zf-DHHC; DHHC palmitoyltransferase
    12. XM_047425841.1XP_047281797.1  palmitoyltransferase ZDHHC16 isoform X10

    13. XM_047425840.1XP_047281796.1  palmitoyltransferase ZDHHC16 isoform X9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      98326355..98337553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366914.1XP_054222889.1  palmitoyltransferase ZDHHC16 isoform X1

      UniProtKB/TrEMBL
      H0Y6E9
    2. XM_054366917.1XP_054222892.1  palmitoyltransferase ZDHHC16 isoform X3

      UniProtKB/TrEMBL
      H0Y6E9
    3. XM_054366923.1XP_054222898.1  palmitoyltransferase ZDHHC16 isoform X8

      UniProtKB/TrEMBL
      B1AMU0
    4. XM_054366918.1XP_054222893.1  palmitoyltransferase ZDHHC16 isoform X4

      UniProtKB/TrEMBL
      H0Y6E9
    5. XM_054366921.1XP_054222896.1  palmitoyltransferase ZDHHC16 isoform X6

      UniProtKB/TrEMBL
      H0Y6E9
    6. XM_054366926.1XP_054222901.1  palmitoyltransferase ZDHHC16 isoform X10

    7. XM_054366915.1XP_054222890.1  palmitoyltransferase ZDHHC16 isoform X2

      UniProtKB/TrEMBL
      B4DNL2, H0Y6E9
    8. XM_054366916.1XP_054222891.1  palmitoyltransferase ZDHHC16 isoform X3

      UniProtKB/TrEMBL
      H0Y6E9
    9. XM_054366920.1XP_054222895.1  palmitoyltransferase ZDHHC16 isoform X6

      UniProtKB/TrEMBL
      H0Y6E9
    10. XM_054366919.1XP_054222894.1  palmitoyltransferase ZDHHC16 isoform X5

      UniProtKB/TrEMBL
      H0Y6E9
    11. XM_054366922.1XP_054222897.1  palmitoyltransferase ZDHHC16 isoform X7

    12. XM_054366925.1XP_054222900.1  palmitoyltransferase ZDHHC16 isoform X10

    13. XM_054366924.1XP_054222899.1  palmitoyltransferase ZDHHC16 isoform X9