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    GNG3 G protein subunit gamma 3 [ Homo sapiens (human) ]

    Gene ID: 2785, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GNG3provided by HGNC
    Official Full Name
    G protein subunit gamma 3provided by HGNC
    Primary source
    HGNC:HGNC:4405
    See related
    Ensembl:ENSG00000162188 MIM:608941; AllianceGenome:HGNC:4405
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HG3D
    Summary
    Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012]
    Expression
    Biased expression in brain (RPKM 92.3), adrenal (RPKM 8.1) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See GNG3 in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62706446..62709201)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62695866..62698618)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62475148..62476673)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4839 Neighboring gene UBX domain protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62455030-62455530 Neighboring gene HNRNPUL2-BSCL2 readthrough (NMD candidate) Neighboring gene LRRN4 C-terminal like Neighboring gene BSCL2 lipid droplet biogenesis associated, seipin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62465704-62466296 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62473607-62474280 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:62475600-62476799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62482895-62483396 Neighboring gene heterogeneous nuclear ribonucleoprotein U like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4843 Neighboring gene tetratricopeptide repeat domain 9C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation. Bell B, et al. J Biol Chem, 1999 Mar 19. PMID 10075696
    2. Regulation of Golgi structure and secretion by receptor-induced G protein βγ complex translocation. Saini DK, et al. Proc Natl Acad Sci U S A, 2010 Jun 22. PMID 20534534, Free PMC Article
    3. Mice with deficiency of G protein gamma3 are lean and have seizures. Schwindinger WF, et al. Mol Cell Biol, 2004 Sep. PMID 15314181, Free PMC Article
    4. Lipid modifications of trimeric G proteins. Wedegaertner PB, et al. J Biol Chem, 1995 Jan 13. PMID 7822269
    5. Differential localization of the gamma 3 and gamma 12 subunits of G proteins in the mammalian brain. Morishita R, et al. J Neurochem, 1997 Feb. PMID 9003074

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of guanine nucleotide binding protein (G protein), gamma 3 (GNG3) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
    Names
    NBP gamma-3
    guanine nucleotide binding protein (G protein), gamma 3
    guanine nucleotide-binding protein gamma-3 subunit
    heterotrimeric guanine nucleotide-binding protein 3D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012202.5 → NP_036334.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

      See identical proteins and their annotated locations for NP_036334.1

      Status: REVIEWED

      Source sequence(s)
      AF087900, AF092129, AP001458, DA123305
      Consensus CDS
      CCDS8032.1
      UniProtKB/Swiss-Prot
      B2R4S7, P29798, P63215, Q61014
      Related
      ENSP00000294117.5, ENST00000294117.6
      Conserved Domains (1) summary
      smart00224
      Location:13 → 75
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      62706446..62709201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426794.1 → XP_047282750.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1

      UniProtKB/Swiss-Prot
      B2R4S7, P29798, P63215, Q61014

    2. XM_006718500.3 → XP_006718563.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1

      See identical proteins and their annotated locations for XP_006718563.1

      UniProtKB/Swiss-Prot
      B2R4S7, P29798, P63215, Q61014
      Conserved Domains (1) summary
      smart00224
      Location:13 → 75
      GGL; G protein gamma subunit-like motifs

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      62695866..62698618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368464.1 → XP_054224439.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1

      UniProtKB/Swiss-Prot
      B2R4S7, P29798, P63215, Q61014

    2. XM_054368463.1 → XP_054224438.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1

      UniProtKB/Swiss-Prot
      B2R4S7, P29798, P63215, Q61014
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63215.1 GenPept UniProtKB/Swiss-Prot:P63215

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