RSF1 remodeling and spacing factor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RSF1provided by HGNC
Official Full Name: remodeling and spacing factor 1provided by HGNC
Primary source: HGNC:HGNC:18118
See related: Ensembl:ENSG00000048649 MIM:608522; AllianceGenome:HGNC:18118
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: XAP8; p325; HBXAP; RSF-1
Summary: This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]
Expression: Ubiquitous expression in adrenal (RPKM 7.3), thyroid (RPKM 7.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q14.1

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (77660009..77872232, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (77593084..77805458, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (77371054..77531768, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genome-Wide Meta-Analysis Identifies Multiple Novel Rare Variants to Predict Common Human Infectious Diseases Risk.
Title: Genome-Wide Meta-Analysis Identifies Multiple Novel Rare Variants to Predict Common Human Infectious Diseases Risk.
[Circular RNA circRSF1 binds to HuR to promote radiation-induced inflammatory phenotype in hepatic stellate cells].
Title: [Circular RNA circRSF1 binds to HuR to promote radiation-induced inflammatory phenotype in hepatic stellate cells].
linc00958/miR-185-5p/RSF-1 modulates cisplatin resistance and angiogenesis through AKT1/GSK3beta/VEGFA pathway in cervical cancer.
Title: linc00958/miR-185-5p/RSF-1 modulates cisplatin resistance and angiogenesis through AKT1/GSK3β/VEGFA pathway in cervical cancer.
miR-129-5p Plays an Anticancer Role in Colon Cancer by Targeting RSF1.
Title: miR-129-5p Plays an Anticancer Role in Colon Cancer by Targeting RSF1.
The chromatin remodeler RSF1 coordinates epigenetic marks for transcriptional repression and DSB repair.
Title: The chromatin remodeler RSF1 coordinates epigenetic marks for transcriptional repression and DSB repair.
Spatiotemporal coordination of the RSF1-PLK1-Aurora B cascade establishes mitotic signaling platforms.
Title: Spatiotemporal coordination of the RSF1-PLK1-Aurora B cascade establishes mitotic signaling platforms.
Circular RNA RSF1 promotes inflammatory and fibrotic phenotypes of irradiated hepatic stellate cell by modulating miR-146a-5p.
Title: Circular RNA RSF1 promotes inflammatory and fibrotic phenotypes of irradiated hepatic stellate cell by modulating miR-146a-5p.
Long Noncoding RNA SNHG6 Promotes Proliferation and Inhibits Apoptosis in Non-small Cell Lung Cancer Cells by Regulating miR-490-3p/RSF1 Axis.
Title: Long Noncoding RNA SNHG6 Promotes Proliferation and Inhibits Apoptosis in Non-small Cell Lung Cancer Cells by Regulating miR-490-3p/RSF1 Axis.
CircRSF1 contributes to endothelial cell growth, migration and tube formation under ox-LDL stress through regulating miR-758/CCND2 axis.
Title: CircRSF1 contributes to endothelial cell growth, migration and tube formation under ox-LDL stress through regulating miR-758/CCND2 axis.
Rsf1 positively regulated Bcell lymphoma 2 (Bcl2), cellular inhibitor of apoptosis 1 (cIAP1) and cIAP2, and downregulated Bcl2associated X protein expression. Nuclear factor kappalightchainenhancer of activated Bcells (NFkappaB) inhibition reversed the effects of Rsf1 on Bcl2.
Title: Rsf‑1 regulates malignant melanoma cell viability and chemoresistance via NF‑κB/Bcl‑2 signaling.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S1117 (e-PCR)
- UniSTS:68118

EST19G6 (e-PCR)
- UniSTS:263200

D11S4558 (e-PCR)
- UniSTS:12588

HBXAP_1276 (e-PCR)
- UniSTS:277305

HBXAP_v383 (e-PCR)
- UniSTS:277305

D11S911 (e-PCR)
- UniSTS:24702

D11S948E (e-PCR)
- UniSTS:40120

STS-AA034409 (e-PCR)
- UniSTS:54202

D11S948E (e-PCR)
- UniSTS:147397

SHGC-172594 (e-PCR)
- UniSTS:182485

RH93405 (e-PCR)
- UniSTS:85217

D11S3829 (e-PCR)
- UniSTS:153059

RH44708 (e-PCR)
- UniSTS:85478

D11S4014 (e-PCR)
- UniSTS:78837

D11S911 (e-PCR)
- UniSTS:40182

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
NOT enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables histone octamer slider activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin organization	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA binding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleosome assembly	EXP Inferred from Experiment more info	PubMed
involved_in nucleosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of viral transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of RSF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RSF complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: remodeling and spacing factor 1

Names: HBV pX-associated protein 8; hepatitis B virus x-associated protein; p325 subunit of RSF chromatin-remodeling complex

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016578.4 → NP_057662.3 remodeling and spacing factor 1

See identical proteins and their annotated locations for NP_057662.3

Status: VALIDATED

Source sequence(s)

AP000580, AP000609, AP002343

Consensus CDS

CCDS8253.1

UniProtKB/Swiss-Prot

Q86X86, Q96T23, Q9H3L8, Q9NVZ8, Q9NYU0

Related

ENSP00000311513.6, ENST00000308488.11

Conserved Domains (5) summary

cd15543
Location:893 → 938

PHD_RSF1; PHD finger found in Remodeling and spacing factor 1 (Rsf-1)

pfam02724
Location:1093 → 1171

CDC45; CDC45-like protein

pfam15612
Location:98 → 148

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:150 → 182

WHIM2; WSTF, HB1, Itc1p, MBD9 motif 2

cl02608
Location:915 → 968

BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

77660009..77872232 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017017923.2 → XP_016873412.1 remodeling and spacing factor 1 isoform X2

Related

ENSP00000434509.1, ENST00000480887.5
XM_005274051.3 → XP_005274108.1 remodeling and spacing factor 1 isoform X1

Conserved Domains (5) summary

cd15543
Location:890 → 935

PHD_RSF1; PHD finger found in Remodeling and spacing factor 1 (Rsf-1)

pfam02724
Location:1090 → 1168

CDC45; CDC45-like protein

pfam15612
Location:98 → 148

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:150 → 182

WHIM2; WSTF, HB1, Itc1p, MBD9 motif 2

cl02608
Location:912 → 965

BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...