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    CREBZF CREB/ATF bZIP transcription factor [ Homo sapiens (human) ]

    Gene ID: 58487, updated on 27-Nov-2024

    Summary

    Official Symbol
    CREBZFprovided by HGNC
    Official Full Name
    CREB/ATF bZIP transcription factorprovided by HGNC
    Primary source
    HGNC:HGNC:24905
    See related
    Ensembl:ENSG00000137504 MIM:606444; AllianceGenome:HGNC:24905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZF; SMILE
    Summary
    Enables identical protein binding activity. Involved in negative regulation of gene expression, epigenetic; regulation of DNA-templated transcription; and response to virus. Located in mitochondrion and nucleoplasm. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in endometrium (RPKM 18.3), spleen (RPKM 18.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CREBZF in Genome Data Viewer
    Location:
    11q14.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (85657990..85682863, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (85594499..85619547, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (85369034..85393906, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5365 Neighboring gene transmembrane protein 126B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5367 Neighboring gene transmembrane protein 126A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:85383205-85383705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:85396033-85396534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:85396535-85397034 Neighboring gene coiled-coil domain containing 89 Neighboring gene synaptotagmin like 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:85472379-85473578 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3822

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ94018

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    CREB/ATF bZIP transcription factor
    Names
    HCF-binding transcription factor Zhangfei
    SHP-interacting leucine zipper protein
    Zhangfei
    host cell factor-binding transcription factor Zhangfei
    small heterodimer partner-interacting leucine zipper

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039618.4NP_001034707.1  CREB/ATF bZIP transcription factor

      See identical proteins and their annotated locations for NP_001034707.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
      Source sequence(s)
      AP000642
      Consensus CDS
      CCDS41697.1
      UniProtKB/Swiss-Prot
      B2R8Q9, Q0P5U9, Q52LT3, Q9NS37
      Related
      ENSP00000433459.1, ENST00000527447.2
      Conserved Domains (1) summary
      cl21462
      Location:219260
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    RNA

    1. NR_028024.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AP000642
    2. NR_028025.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AP000642
    3. NR_028026.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AP000642
    4. NR_028027.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks four alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AP000642
    5. NR_165399.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642
    6. NR_165400.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642, KF511165
    7. NR_165401.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642, KF511165
    8. NR_165402.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642
    9. NR_165403.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642
    10. NR_165404.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642
    11. NR_165405.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642
    12. NR_165406.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642
    13. NR_165407.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642
    14. NR_165408.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642
    15. NR_165409.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642
    16. NR_165410.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642
    17. NR_165411.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000642

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      85657990..85682863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018086.2XP_016873575.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0
      Conserved Domains (1) summary
      cl21462
      Location:219260
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    2. XM_047427377.1XP_047283333.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0
    3. XM_047427378.1XP_047283334.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0
      Related
      ENSP00000507358.1, ENST00000682836.1
    4. XM_047427376.1XP_047283332.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0
    5. XM_047427375.1XP_047283331.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0
    6. XM_017018090.2XP_016873579.1  CREB/ATF bZIP transcription factor isoform X2

      UniProtKB/Swiss-Prot
      B2R8Q9, Q0P5U9, Q52LT3, Q9NS37
      Conserved Domains (1) summary
      cl21462
      Location:219260
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    7. XM_047427379.1XP_047283335.1  CREB/ATF bZIP transcription factor isoform X2

      UniProtKB/Swiss-Prot
      B2R8Q9, Q0P5U9, Q52LT3, Q9NS37
    8. XM_017018088.2XP_016873577.1  CREB/ATF bZIP transcription factor isoform X2

      UniProtKB/Swiss-Prot
      B2R8Q9, Q0P5U9, Q52LT3, Q9NS37
      Conserved Domains (1) summary
      cl21462
      Location:219260
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    9. XM_017018089.2XP_016873578.1  CREB/ATF bZIP transcription factor isoform X2

      UniProtKB/Swiss-Prot
      B2R8Q9, Q0P5U9, Q52LT3, Q9NS37
      Conserved Domains (1) summary
      cl21462
      Location:219260
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    10. XM_006718642.4XP_006718705.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0
      Related
      ENSP00000435762.1, ENST00000525639.1
      Conserved Domains (1) summary
      cl21462
      Location:219260
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    11. XM_011545195.3XP_011543497.1  CREB/ATF bZIP transcription factor isoform X2

      See identical proteins and their annotated locations for XP_011543497.1

      UniProtKB/Swiss-Prot
      B2R8Q9, Q0P5U9, Q52LT3, Q9NS37
      Related
      ENSP00000434281.1, ENST00000490820.2
      Conserved Domains (1) summary
      cl21462
      Location:219260
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      85594499..85619547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369568.1XP_054225543.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0
    2. XM_054369567.1XP_054225542.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0
    3. XM_054369574.1XP_054225549.1  CREB/ATF bZIP transcription factor isoform X2

      UniProtKB/Swiss-Prot
      B2R8Q9, Q0P5U9, Q52LT3, Q9NS37
    4. XM_054369571.1XP_054225546.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0
    5. XM_054369572.1XP_054225547.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0
    6. XM_054369573.1XP_054225548.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0
    7. XM_054369570.1XP_054225545.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0
    8. XM_054369569.1XP_054225544.1  CREB/ATF bZIP transcription factor isoform X1

      UniProtKB/TrEMBL
      E9PIM0
    9. XM_054369575.1XP_054225550.1  CREB/ATF bZIP transcription factor isoform X2

      UniProtKB/Swiss-Prot
      B2R8Q9, Q0P5U9, Q52LT3, Q9NS37

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_021212.1: Suppressed sequence

      Description
      NM_021212.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.