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    FBRS fibrosin [ Homo sapiens (human) ]

    Gene ID: 64319, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FBRSprovided by HGNC
    Official Full Name
    fibrosinprovided by HGNC
    Primary source
    HGNC:HGNC:20442
    See related
    Ensembl:ENSG00000156860 MIM:608601; AllianceGenome:HGNC:20442
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBS; FBS1
    Summary
    Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins, 1998 [PubMed 9809749]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in testis (RPKM 34.3), bone marrow (RPKM 18.4) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FBRS in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30658431..30670810)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (31045402..31057781)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30669752..30682131)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30621737-30622706 Neighboring gene uncharacterized LOC124903678 Neighboring gene zinc finger protein 689 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:30626940-30627180 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30644787-30645738 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30645739-30646689 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30661003-30661520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30661521-30662036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7383 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7384 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7387 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7388 Neighboring gene proline rich 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10718 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:30681557-30681750 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30688172-30689072 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30689073-30689972 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30689973-30690873 Neighboring gene RNA, U6 small nuclear 416, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30693026-30693526 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:30697048-30697206 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:30705076-30705670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10719 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10720 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7389 Neighboring gene Sharpr-MPRA regulatory region 39 Neighboring gene uncharacterized LOC730183

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and analysis of the cDNA for human fibrosin, a novel fibrogenic lymphokine. Prakash S, et al. DNA Cell Biol, 1998 Oct. PMID 9809749
    2. Fibrosin: A novel lymphokine in alcohol-induced fibrosis. Prakash S, et al. Exp Mol Pathol, 1999 Sep. PMID 10493891
    3. Fibrosin: a novel lymphokine in wound healing. Prakash S, et al. Exp Mol Pathol, 2001 Dec. PMID 11733950
    4. Fibrosin, a novel fibrogenic cytokine, modulates expression of myofibroblasts. Prakash S, et al. Exp Mol Pathol, 2007 Feb. PMID 17083929
    5. Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine, fibrosin. Prakash S, et al. Proc Natl Acad Sci U S A, 1995 Mar 14. PMID 7892239, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In a rat model, ethanol can directly stimulate fibroblast proliferation and production of fibrogenic cytokines, particularly fibrosin, which appears to contribute to alcohol-induced hepatic fibrosis in vivo.
      Title: Fibrosin: A novel lymphokine in alcohol-induced fibrosis.
    2. Characterization of mouse fibrosin and demonstration of growth-stimulating effects in fibroblasts.
      Title: Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine, fibrosin.
    3. In a mouse model, fibrosin upregulates the appearance of myofibroblasts during wound healing and may be important in the process of scarring.
      Title: Fibrosin, a novel fibrogenic cytokine, modulates expression of myofibroblasts.
    4. Fibrosin stimulates epithelialization of wounds in mouse and reduces wound healing time by approximately 30-40%.
      Title: Fibrosin: a novel lymphokine in wound healing.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11618

    General protein information

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    Preferred Names
    probable fibrosin-1
    Names
    fibrogenic lymphokine
    fibrosin 1
    probable fibrosin-1 long transcript protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105079.3 → NP_001098549.2  probable fibrosin-1

      Status: VALIDATED

      Source sequence(s)
      AC093249
      Consensus CDS
      CCDS45462.2
      UniProtKB/TrEMBL
      J3KNZ9
      Related
      ENSP00000348489.5, ENST00000356166.11
      Conserved Domains (1) summary
      pfam15336
      Location:602 → 802
      Auts2; Autism susceptibility gene 2 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      30658431..30670810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545916.3 → XP_011544218.1  probable fibrosin-1 isoform X2

      Conserved Domains (1) summary
      pfam15336
      Location:592 → 792
      Auts2; Autism susceptibility gene 2 protein

    2. XM_011545917.3 → XP_011544219.1  probable fibrosin-1 isoform X1

      Conserved Domains (1) summary
      pfam15336
      Location:592 → 792
      Auts2; Autism susceptibility gene 2 protein

    3. XM_047434483.1 → XP_047290439.1  probable fibrosin-1 isoform X3

    4. XM_011545919.3 → XP_011544221.1  probable fibrosin-1 isoform X4

      Conserved Domains (1) summary
      pfam15336
      Location:580 → 780
      Auts2; Autism susceptibility gene 2 protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      31045402..31057781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313673.1 → XP_054169648.1  probable fibrosin-1 isoform X2

    2. XM_054313672.1 → XP_054169647.1  probable fibrosin-1 isoform X1

    3. XM_054313674.1 → XP_054169649.1  probable fibrosin-1 isoform X3

    4. XM_054313675.1 → XP_054169650.1  probable fibrosin-1 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_022452.1: Suppressed sequence

      Description
      NM_022452.1: This RefSeq was permanently suppressed because the CDS was partial.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HAH7.3 GenPept UniProtKB/Swiss-Prot:Q9HAH7

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